Grady Memorial Hosp, 80 Jesse Hill Jr. Dr., D119
Atlanta, GA 30303
404 616-4800 Phone
Director, Clinical Chemistry, Grady Memorial Hospital
B.S. Chemistry, Purdue University, West Lafayette, IN, 1970 - 1974
Ph.D. Analytical Chemistry, Purdue University, West Lafayette, IN, 1974 - 1979
- Research Overview
I engage in the following research activities:
1. The proper approach to and science behind the evaluation of clinical laboratory methods.
2. Investigation of novel biomarkers for diagnosis and monitoring of disease.
3. Method development and evaluation of clinical laboratory technology for new applications, and for diagnostic reagent and instrument companies.
I serve as Director of Clinical Chemistry, Toxicology, and Point-of-Care Testing at Grady Memorial Hospital. My particular interests include the cost-effective utilization of laboratory medicine for patients with diabetes, cardiovascular problems, and toxicology applications, as well as the reduction of non-analytical sources of error. I am currently Secretary of the National Academy of Clinical Biochemistry.
AACC Chicago Section Annual Research Award, Chicago, IL,, 2000
"Preferred Partners" Education Grant from Boehringer Mannheim, 1995
Elected a Fellow of the National Academy of Clinical Biochemistry, 1993
W.D. Paulson, W. L. Roberts, A.A. Lurie, D.D. Koch, A.W. Butch, and J.J. Aguanno, Clinical impact of the wide variation in serum anion gap measurements made by different chemistry analyzers. Am. J. Clin. Pathol. 110:735-42 (1998).
J.B. Watson, K.E. Lee, R. Klein, B.E. Klein, and D.D. Koch, Epidemiological evidence for the disruption of ionized calcium homeostasis in the elderly. J. Clin. Epidemiol. 50:845-9 (1997).
P.C. Fallest-Strobl, D. D. Koch, J.H. Stein, and P.E. McBride, Homocysteine: a new risk factor for atherosclerosis. Am. Fam. Phys., 56:1607-16 (1997).
D.D. Koch, How to evaluate and implement new technologies in an era of managed care and cost containment. Clin. Chem. 42:797-806 (1996).
L. Barker, D.D. Koch, and F.H. Wians Jr., Validation of the DCA 2000 hemoglobin A1C system. Clin. Lab. Sci. 8:331-3 (1995).
D.D. Koch, F.H. Wians Jr., D. Davis, and D. Burton, Analytical performance characteristics of the T4 method in the Abbott AxSym immunoassay analyzer. Clin. Lab. Sci. 8:327-30 (1995)
F.H. Wians, Jr., L.B. Baskin, J.H. Keffer, and D.D. Koch, Evaluation and implementation of an immunochemiluminometric assay (ICMA) for quantifying CK-MB concentration. Clin. Lab. Sci. 8:334-8 (1995).
Y. Shenker, D. Meranda, C. Clinkingbeard, D. Lawrence, and D.D. Koch, Effect of atrial natriuretic hormone on metoclopramide-induced stimulation of aldosterone. J. Lab. Clin. Med. 120:297-304 (1992)
B.M. Hill, R.H. Laessig, D.D. Koch, and D.J. Hassemer, Comparison of plastic vs. glass evacuated serum-separator (SST") blood-drawing tubes for common clinical chemistry determinations. Clin. Chem. 38:1474-8 (1992).
D.D. Koch and R.C. Miller, "Half-life" is erroneously used to describe the disappearance of erythrocytes and hemoglobin from the circulation. Clin. Chem. 38:1389-90 (1992).
D.D. Koch, J.J. Oryall, E.F. Quam, D.H. Feldbruegge, D.E. Dowd, P.L. Barry, and J.O Westgard, Selection of medically useful quality control procedures for individual tests on a multitest analytical system. Clin. Chem. 36:230-233 (1990).
J.O. Westgard, J.J. Oryall, and D.D. Koch, Predicting effects of QC practices on the cost-effective operation of a stable multitest analytical system. Clin. Chem. 36:1760-1764 (1990).
D.D. Koch, Fructosamine: How useful is it? Lab. Med. 21:497-503 (1990).
M.J. Koch, G. Casucci, L.K. Haessig, D.D. Koch, T.E. Parks, R.B. Wise, and W.B. Gray, Blood gas quality control using tonometry. Respiratory Management 19:66-68 (1989).
D.D. Koch, D.J. Hassemer, D.A. Wiebe, and R.H. Laessig, Testing cholesterol accuracy--performance of several common laboratory instruments. J. Amer. Med. Assoc. 260:2552-2557 (1988).
M.J. Koch, G.C. Casucci, L.K. Haessig, D.D. Koch, T.E. Parks, R.J. Wise, and W.B. Gray, Evaluation of Marquest QC-IV Tonometer. Clin. Lab. Sci. 1:196-197 (1988).
S.J. Updike, M.S. Shults, C.C. Capelli, D. von Heimburg, R.K. Rhodes, N. Joseph-Tipton, B. Anderson, and D.D. Koch, Laboratory evaluation of a new, reusable blood glucose sensor. Diabetes Care 11:801 (1988).
D.D. Koch and D.H. Feldbruegge, Optimized kinetic method for automated determination of beta-hydroxybutyrate. Clin. Chem. 33:1761 (1987).
D.D. Koch, Concepts in the validation of neurochemical methods: the proper generation and use of statistics. Life Sci. 41:853 (1987).
D.D. Koch and G.L. Polzin, Effect of sample preparation and LC column choice on selectivity and precision of plasma catecholamine determination. J. Chromatogr. 386:19 (1987).
J.A. Lott, L.B. Abbott, and D.D. Koch, An evaluation of the DuPont aca IV: does it meet medical needs? Clin. Chem. 31:281 (1985).
D.D. Koch, Electrolyte technology: current and future. J. Med. Technol. 2:40 (1985).
M. Koch, L. Haessig, and D. Koch, Blood gas temperature corrections, J. Med. Technol. 1:532 (1984).
D.D. Koch and G. Polzin, The determination of urinary MHPG by liquid chromatography with electrochemical detection. J. Chromatogr. 317:327 (1984).
M.E. Keen, C.C. Garber, and D.D. Koch, Analytical absorbance errors in a patient receiving intravenous iron dextran. Clin. Chem. 29:1865 (1983).
D.D. Koch and J.H. Ladenson, Errors in determination of potassium in physiological fluids with valinomycin electrodes. Anal. Chem. 55:1807 (1983).
D.D. Koch, D. Parrish, and J.H. Ladenson, Evaluation of a direct potentiometric method for sodium and potassium used in the DuPont aca. Clin. Chem. 29:1090 (1983).
D.D. Stark, J.G. Shanes, R.L. Baron, and D.D. Koch, Biochemical features of urinothorax. Arch. Intern. Med. 142:1509 (1982).
F.S. Apple, D.D. Koch, S. Graves, and J.H. Ladenson, Relationship between direct potentiometric and flame photometric measurement of sodium in blood. Clin. Chem. 28:1931 (1982).
J.H. Ladenson, F.S. Apple, J.J. Aguanno, and D.D. Koch, Sodium measurements in multiple myeloma: two techniques compared. Clin. Chem. 28:2383 (1982).
R.L. Baron, D.D. Stark, B.L. McClennan, J.G. Shanes, G.L. Davis, and D.D. Koch, Intrathoracic extension of retroperitoneal urine collections. Am. J. Roentgenol. 137:37 (1981).
J.H. Ladenson, F.S. Apple, and D.D. Koch, Misleading hyponatremia due to hyperlipemia: a method-dependent error. Ann. Int. Med. 95:707 (1981).
D.D. Koch and P.T. Kissinger, Liquid chromatography with precolumn sample enrichment and electrochemical detection. Determination of serotonin in small amounts of serum and plasma. Anal. Chem. 52:27 (1980).
D.D. Koch and P.T. Kissinger, Liquid chromatography with precolumn sample enrichment and electrochemical detection. Regional determination of serotonin and 5-hydroxyindoleacetic acid in brain tissue. Life Sci. 26:1099 (1980).
D.D. Koch and P.T. Kissinger, Determination of tryptophan and several of its metabolites in physiological samples by reverse-phase liquid chromatography with electrochemical detection. J. Chromatogr. 164:441 (1979).
F.H. Wians, Jr., D.D. Koch, and A. Haara, Quality control and quality assurance, Chap. 8 in Clinical Chemistry Laboratory Management and Clinical Correlations, K. Lewandrowski, Ed. Philadelphia: Lippincott, Williams & Wilkins, 2002, pp. 81-106.
D.D. Koch and T. Peters, Jr., Selection and evaluation of methods, Chap. 13 in Tietz Textbook of Clinical Chemistry, 3rd ed., C.A. Burtis and E.R. Ashwood. Eds. Philadelphia: W.B. Saunders Co., 1999, pp. 320-35.
D.D. Koch and T. Peters, Jr., Selection and evaluation of methods-- with an introduction to statistical techniques, Chap. 12 in Tietz Fundamentals of Clinical Chemistry, C.A. Burtis and E.R. Ashwood, Eds. Philadelphia: W.B. Saunders Co., 1996.
D.D. Koch and B. Cleveland, Instrumentation for the measurement of blood gases and electrolytes, Chap. 4 in Clinical Laboratory Instrumentation and Automation: Principles, Applications, and Selection; K.M. Ward, C.A. Lehmann, and A.M. Leiken, Eds. Philadelphia: W.B. Saunders Co., 1994, pp. 93-133.
D.D. Koch and T. Peters, Jr., Selection and evaluation of methods, Chap. 15 in Tietz Textbook of Clinical Chemistry, 2nd ed., C.A. Burtis and E.R. Ashwood, Eds. Philadelphia: W.B. Saunders Co., 1994, pp. 508-525.
D.D. Koch and P.T. Kissinger, Determination of serotonin in serum by liquid chromatography with precolumn sample enrichment and electrochemical detection, Chap. 31 in Clinical Liquid Chromatography, Vol. 2, P.M. Kabra and L.J. Marton, Eds. Boca Raton, FL: CRC Press, Inc., 1983.
D.D. Koch and P.T. Kissinger, Urinary tryptophan, serotonin and 5-hydroxyindoleacetic acid by liquid chromatography/electrochemistry, Chap. 30 in Clinical Liquid Chromatography, Vol. 2, P.M. Kabra and L.J. Marton, Eds. Boca Raton, FL: CRC Press, Inc., l983.
G.C. Davis, W. Jacobs, P.T. Kissinger, D.D. Koch, C.S. Bruntlett, and R.E. Shoup, Reverse-phase chromatography with amperometric detection: the determination of aromatic amino acid metabolites and the activity of related enzymes. Biological/Biomedical Applications of Liquid Chromatography, Vol. 3, G.L. Hawk, Ed. New York: Marcel Dekker, 1981, pp. 247-283.
G.C. Davis, D.D. Koch, P.T. Kissinger, C.S. Bruntlett, and R.E. Shoup, Determination of tyrosine and tryptophan metabolites in body fluids using electrochemical detection. Chap. 12 in Liquid Chromatography in Clinical Analysis, P.M. Kabra and L.J. Marton, Eds. Clifton, NJ: Humana Press, Inc., 1981.
R.E. Vanderlinde, J. Goodwin, D. Koch, D. Scheer, S. Steindel, and G. Cembrowski, Guidelines for Providing Quality Stat Laboratory Services. Washington, DC: AACC Press, 1987.
D.D. Koch, Handbook of Interpretation of Diagnostic Tests, by Jacques Wallach. Clin. Chem. 45:722 (1999).
D.J. Hassemer, D.A. Wiebe, R.H. Laessig, and D.D. Koch, Testing cholesterol accuracy. Letter to the Editor, J. Amer. Med. Assoc. 263:375-376 (1990).
J.H. Ladenson, F.S. Apple, J.J. Aguanno, and D.D. Koch, Nutriumbestimmung bei Multiplem Myelom: ein Vergleich ziveier Techniken. Git. Lab. Med. 6:176 (1983).