Pathology Faculty Member

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    Experimental Pathology
    Dental Building
    Atlanta GA
    404-727-8457 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Max Dale Cooper, MD

    Immunology

    Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Eminent Scholar, Georgia Research Alliance

    Professor, Emory Center for AIDS Research, Emory University

    Professor, Emory Vaccine Center, Emory University


    Pathology Division(s):
    Experimental Pathology


    Email Address:
    max.cooper@emory.edu


    Education:

    M. D.   Tulane University Medical School, 1955 - 1957



    Research Interests:

    -
    My laboratory pursues ontogenetic and phylogenetic studies of the adaptive immune system in parallel with the analysis of immunological diseases in humans. Current projects include the role of immunoglobulin and non-immunoglobulin genes in B cell development, and the evolution of adaptive immune systems in vertebrates.



    Selected Publications:

    Published and Accepted Research Articles -

    Herrin, B.R., Alder, M.N., Roux, R.H., Sina, C., Ehrhardt, G.R.A., Boydston, J.A., Turnbough, Jr., C.L., and Cooper, M.D.: Structure and Specificity of Lamprey Monoclonal Antibodies. Proc. Natl. Acad. Sci. USA 105(6):2040-2045, 2008.


    Alder, M.N., Herrin, B.R., Sadlonova, A., Stockard, C.R., Grizzle, W.E., Gartland, L.A., Gartland, G.L., Boydston, J.A., Turnbough, Jr., C.L., and Cooper, M.D.: Antibody responses of variable lymphocyte receptors in the lamprey. Nat. Immunol. 9:319-327, 2008.


    Haga, C.L., Ehrhardt, G.R.A., Boohaker, R.J., Davis, R.S., and Cooper, M.D.: Fc Receptor-like 5 inhibits B cell activation by recruiting SHP-1 tyrosine phosphatase. Proc. Natl. Acad. Sci. USA. 104:9770-9775, 2007.


    Hirano, M., Davis, R.S., Fine, W.D., Nakamura, S., Shimizu, K., Yagi, H., Kato, K., Stephan, R.P., and Cooper, M.D.: IgEb immune complexes activate macrophages via Fc¿RIV binding. Nat. Immunol. 8:762-771, 2007.


    Goitsuka, R., Chen, C.H., Benyon, L., Asano, Y., Kitamuira, D., and Cooper, M.D.: Chicken cathelicidin-1, an antimicrobial guardian at the mucosal M cell gateway. Proc. Natl. Acad. Sci. USA. 104:15063-15068, 2007.


    Litman, G.W., and Cooper, M.D.: Why study the evolution of immunity? Nat. Immunol. 8:547-548, 2007.


    Munfus, D.L., Haga, C.L., Burrows, P.D., and Cooper, M.D.: A conserved gene family encodes transmembrane proteins with fibronectin, immunoglobulin and leucine rich repeat domains (FIGLER). BMC Genomics. 5:36, 2007.


    Pancer, Z., and Cooper, M.D.: The evolution of adaptive immunity. Ann. Rev. Immunol. 24:497-518, 2006.


    Fujiwara, N., Kitamura, D., Cooper, M. D., Hozumi, N., Chen, C. H., and Goitsuka, R.: A novel avian homologue of CD72, chB1r, down-modulates BCR-mediated activation signals. Int. Immunol. 18:775-783, 2006.


    Cooper, M. D., and Alder, M. N.: The Evolution of Adaptive Immune Systems. Cell 124:815-822, 2006.


    Zhang, Z., Espinoza, C. R., Yu, Z., Stephan, R., He, T., Williams, G. S., Burrows, P. D., Hagman, J., and Cooper, M. D.: Transcription factor Pax5/BSAP transactivates the RAG-mediated VH->DJH rearrangement of immunoglobulin genes. Nat. Immunol. 7:616-624, 2006.


    Maltai, L., Lovering, R., Taranin, A. V., Colonna, M., Ravetch, J. V., Dalla-Favera, R., Burrows, P. D., Cooper, M. D., and Davis, R. S.: New proposed nomenclature for the Fc receptor-like (FCRL) family. Nat. Immunol. (Correspondence). 7:431-432, 2006.


    Pancer, Z., Kasahara, M., Saha, N. R., Kasamatusu, J., Amemiya, C. T., and Cooper, M. D.: Variable lymphocyte receptors in hagfish. Proc. Natl. Acad. Sci. USA 102:9224-9229, 2005.


    Kang, S-M., Narducci, M. G., Picchio, M. D., Mongiovi, A. M., Lazzeri, C., Caprini, E., Remotti, D., Bichi, R., Rothstein, J., Croce, C. M., Cooper, M. D., and Russo, G.: Impaired T and B cell development in Tcl1 deficient mice. Blood 105:1288-1294, 2005.


    Leu, C-M., Davis, R. S., Gartland, L. A., Fine, W. D., and Cooper, M. D.: FcRH1: an activation co-receptor on human B cells. Blood 105:1121-1126, 2005.


    Masuda, K., Davis, R. S., Maruyama, T., Zhang, J., He, T., Cooper, M. D., Wang, J. O., and Burrows, P. D.: FcRY, an Fc receptor related gene differentially expressed during B cell development and activation. Gene 363:32-40, 2005.


    Davis, R S., Ehrhardt, G. R. A., Leu, C-M., Hirano, M., and Cooper, M. D.: An extended family of Fc receptor relatives. Eur. J. Immunol. 35:674-680, 2005.


    Alder, M. N., Rogozin, I. B., Iyer, L. M., Glazko, G. V., Cooper, M. D., and Pancer, Z.: Diversity and function of adaptive immune receptors in a jawless vertebrate. Science 310:1970-1973, 2005.


    Cannon, J. P., Haire, R. N., Pancer, Z., Mueller, M. G., Skapura, D., Cooper, M. D., and Litman, G. W.: Variable domains and a VpreB-like molecule are present in a jawless vertebrate. Immunogenetics 56:924-929, 2005.


    Ehrhardt, G. R. A., Hsu, J. T., Gartland, L., Leu, C-M., Zhang, S., Davis, R. S., and Cooper, M. D.: Expression of the immunoregulatory molecule of FcRH4 defines a distinctive tissue-based population of memory B cells. J. Exp. Med. 202:783-791, 2005.


    Masuda, K., Kubagawa, H., Ikaa, T., Chen, C-C., Kakugawa, K., Hattori, M., Cooper, M. D., Minato, N., Katsura, Y., and Kawamoto, H.: Prethymic T cell development defined by the expression of paired immunoglobulin-like receptors. EMBO J. 24:4052-4060, 2005.


    Marchio, S., Lahdenranta, J., Schlingemann, R. O., Valdembri, D., Wesseling, P., Arap, M. A., Hajitou, A., Ozawa, M., Giordano, R. J., Nanus, D. M., Dijkman, H. B. P. M., Oosterwijk, E., Sidman, R. L., Cooper, M. D., Bussolino, F., Pasqualini, R., and Arap. W.: Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5:151-162, 2004.


    Davis, R. S., Stephan, R. P., Chen, C-C., Dennis, Jr., Glynn, Cooper, M. D.: Differential B cell expression of mouse Fc receptor homologs. Int. Immunol. 16:1343-1353, 2004.


    Pancer, Z., Mayer, W. E., Klein, J., and Cooper, M. D.: A prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey. Proc. Natl. Acad. Sci. USA. 101:13273-13278, 2004.


    Pancer, Z., Amemiya, C. T., Ehrhardt, G. R. A., Ceitlin, J., Gartland, G. L., and Cooper, M. D.: Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey. Nature 430:174-180, 2004.


    Khalturin, K., Pancer, Z., Cooper, M. D., and Bosch, T. C. G.: Recognition strategies in the innate immune system of ancestral chordates. Mol. Immunol. 41:1077-1087, 2004.


    Zhang, Z., Zemlin, M., Wang, Y-H., Munfus, D., Huye, L. E., Findley, H. W., Bridges, S. L., Jr., Roth, D. B., Burrows, P. D., and Cooper, M. D.: Contributions of VH gene replacement to the B cell repertoire in humans. Immunity 19:21-31, 2003.


    Ehrhardt, G. R. A., Davis, R. S., Hsu, J. T., Leu, C-M., Ehrhardt, A., and Cooper, M. D.: The inhibitory potential of Fc receptor homolog 4 on memory B cells. Proc. Natl. Acad. Sci. USA 100:13489-13494, 2003.


    Tun, T., Kubagawa, Y., Dennis, G., Burrows, P. D., Cooper, M. D., and Kubagawa, H.: Genomic structure of mouse PIR-A6, an activating member of the paired immunoglobulin-like receptor gene family. Tissue Antigens 61:220-230, 2003.


    Sato, A., Uinuk-ool, T. S., Kuroda, N., Mayer, W. E., Takezaki, N., Dongak, R., Figueroa, F., Cooper, M. D., and Klein, J.: Macrophage migration inhibitory factor (MIF) of jawed and jawless fishes: implications for its evolutionary origin. Dev. Comp. Immunol. 27:401-412, 2003.


    Mitsui, T., Nomura, S., Okada, M., Ohno, Y., Kobayashi, H., Nakashima, Y., Murata, Y., Takeuchi, M., Nagasaka, T., Wang, J. O., Cooper, M. D., and Mizutani, S.: Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice. Mol. Med. 9:57-62, 2003.


    Wang, Y-H., Zhang, Z., Burrows, P. D., Kubagawa, H., Bridges, S. L., Jr., Findley, H. W., and Cooper, M. D.: V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B cell differentiation. Blood. 101:1030-1037, 2003.


    Wang, Y-H., Stephan, R. P., Scheffold, A., Kunkel, D., Karasuyama, H., Radbruch, A., and Cooper, M. D.: Differential surrogate light chain expression governs B cell differentiation. Blood 99:2459-2467, 2002.


    Davis, R. S., Li, H., Chen, C-C., Wang, Y-H., Cooper, M. D., and Burrows, P. D.: Definition of an Fc receptor related gene (FcRX) expressed in human and mouse B cells. Int. Immunol. 14:1075-1083, 2002.


    Narducci, M. G., Fiorenza, M. T., Kang, S-M., Bevilacqua, A., Di Giacomo, M., Remotti, D., Picchio, M. D., Fidanza, F., Cooper, M. D., Croce, M. M., Mangia, F., and Russo, G.: TCL1 participates in early embryonic development and is overexpressed in human seminomas. Proc. Natl. Acad. Sci. USA 99:11712-11717, 2002.


    Monteiro, R. C., Moura, I. C., Launay, P., Tsuge, T., Haddad, E., Benhamou, M., Cooper, M. D., and Arcos-Fajardo, M.: Pathogenic significance of IgA receptor interactions in IgA nephropathy. Trends Mol. Med. 8:464-468, 2002.


    Mayer, W. E., Uinuk-ool, T., Tichy, H., Gartland, L. A., Klein, J., and Cooper, M. D.: Isolation and characterization of lymphocyte-like cells from a lamprey. Proc. Natl. Acad. Sci. USA 99:14350-14355, 2002.


    Kong, F-K., Chen, C. H., and Cooper, M. D.: Reversible disruption of thymic function by steroid treatment. J. Immunol. 168:6500-6505, 2002.


    Uinuk-ool, T. S., Mayer, W. E., Sato, A., Takezaki, N., Benyon, L., Cooper, M. D., and Klein, J.: Identification and characterization of a Tap-family gene in the lamprey. Immunogenetics 55:38-48, 2002.


    Uinuk-ool, T., Sato, A., Dongak, R., Mayer W. E., Cooper, M. D., and Klein, J.: Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activites of mammalian lymphocytes. Proc. Natl. Acad. Sci. USA 99:14356-14361, 2002.


    Moura, I. C., Centelles, M. N., Arcos-Farjardo, M., Malheiros, D. M., Collawn, J. E., Cooper, M. D., and Monteiro, R. C.: Identification of the transferrin receptor as a novel immunoglobulin (Ig) A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. J. Exp. Med. 194:417-425, 2001.


    Stephan, R. P., Elgavish, E., Karasuyama, H., Kubagawa, H., and Cooper, M. D.: Analysis of VpreB expression during B lineage differentiation in l5-deficient mice. J. Immunol. 167:3734-3739, 2001.


    Uehara, T., Bl¿ry, M., Kang, W-W., Chen, C-C., Ho, L. H., Gartland, G. L., Liu, F-T., Vivier, E., Cooper, M. D., and Kubagawa, H.: Inhibition of IgE-mediated mast cell activation by the paired immunoglobulin-like receptor PIR-B. J. Clin. Invest. 108:1041-1050, 2001.


    Gongora, R., Stephan, R. P., Zhang, Z., and Cooper, M. D.: An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons. Immunity 14:727-737, 2001.


    Goitsuka, R., Mamada, H., Kitamura, D., Cooper, M. D., and Chen, C. H.: Genomic structure and transcriptional regulation of the early B-cell gene chB1. J. Immunol. 167:1454-1460, 2001.


    Davis, R. S., Wang, Y-H., Kubagawa, H., and Cooper, M. D.: Identification of a family of Fc receptor homologs with preferential B cell expression. Proc. Natl. Acad. Sci. USA. 98:9772-9777, 2001.


    Laird, D. J., De Tomaso, A. W., Cooper, M. D., and Weissman, I. L.: 50 million years of chordate evolution: Seeing the origins of adapative immunity. Proc. Natl. Acad. Sci. USA 97:6924-6926, 2000.


    Dennis, G., Jr., Kubagawa, H. and Cooper, M. D.: Paired Ig-like receptor homologs in birds and mammals share a common ancestor with mammalian Fc receptors. Proc. Natl. Acad. Sci. USA 97:13245-13250, 2000.


    Gongora, R., Stephan, R. P., Schreiber, R. D., and Cooper, M. D.: Stat-1 is not essential for inhibition of B lymphopoiesis by type I IFNs. J. Immunol. 165:2362-2366, 2000.


    Rosen, F. S., Eible, M., Roifman, C., Fischer, A., Volanakis, J., Aiuti, F., Notarangelo, L., Kishimoto, T., Resnick, I. B., Hammarstrom, L., Segar, R., Chapel, H., Cooper, M. D., Geha, R. S., Good, R. A., Waldmann, T. A., and Wedgwood, R. J. P.: Primary immunodeficiency diseases. Report of an IUIS Scientific Committee. Clin. Exp. Immunol. 118:1-28, 1999.


    Chen, C-C., Hurez, V., Brockenbrough, J. S., Kubagawa, H., and Cooper, M. D.: Paternal monoallelic expression of the paired immunoglobulin-like receptors PIR-A and PIR-B. Proc. Natl. Acad. Sci. USA 96:6868-6872, 1999.


    Kubota, T., Wang, J-Y., Gobel, T. W. F., Hockett, R., Cooper, M. D., and Chen, C. H.: Characterization of an avian (Gallus gallus domesticus) TCR ¿/¿ gene locus. J. Immunol. 163:3858-3866, 1999.


    Ngo, V. N., Korner, H., Gunn, M. D., Schmidt, K. N., Riminton, D. S., Cooper, M. D., Browning, J. L., Sedgwick, J. D., and Cyster, J. G.: Lymphotoxin-¿/¿ and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189:403-412, 1999.


    Benlagha, K., Guglielmi, P., Cooper, M. D., and Lassoued, K.: Modification of Ig¿ and Ig¿ expression as a function of B lineage differentiation. J. Biol. Chem. 274:19389-19396, 1999.


    Kong, F-K., Chen, C. H., Six, A., Hockett, R. D., and Cooper, M. D.: T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool. Proc. Natl. Acad. Sci. USA 96:1536-1540, 1999.


    Kubagawa, H., Chen, C-C., Ho, L-H., Shimada, T., Gartland, L., Mashburn, C., Uehara, T., Ravetch, J. V., and Cooper, M. D.: Biochemical nature and cellular distribution of the paired immunoglobulin-like receptors, PIR-A and PIR-B. J. Exp. Med. 189:309-317, 1999.


    Mayo, M. S., Paramithiotis, E., and Cooper, M. D.: B lymphocyte migration to the bone marrow of humans is not random. Statist. Med. 18:223-231, 1999.


    Kubagawa, H., Cooper, M. D., Chen, C. C., Ho, L. H., Alley, T. L., Hurez, V., Tun, T., Uehara, T., Shimada, T., Vivier, E., and Burrows, P. D.: Paired immunoglobulin-like receptors of activating and inhibitory types. Curr. Top. Microbiol. Immunol. 244:137-149, 1999.


    Ho, L. H., Uehara, T., Chen, C. C., Kubagawa, H., and Cooper, M. D.: Constitutive tyrosine phosphorylation of the inhibitory paired immunoglobulin-like receptor PIR-B. Proc. Natl. Acad. Sci. USA 96:15086-15090, 1999.


    Fujihashi, K., Dohi, T., Kweon, M-N., McGhee, J. R., Cooper, M. D., Tonegawa, S., and Kiyono, H.: gdT cells regulate mucosally induced tolerance in a dose dependent fashion. Int. Immunol. 11:1907-1916, 1999.


    Dennis, G., Jr., Stephan, R. P., Kubagawa, H., and Cooper, M. D.: Characterization of paired immunoglobulin-like receptors in rats. J. Immunol. 163:6371-6377, 1999.


    Bl¿ry, M., Kubagawa, H., Chen, C-C., V¿ly, F., Cooper, M. D., and Vivier, E.: The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. USA 95:2446-2451, 1998.


    Alley, T. L., Cooper, M. D., Chen, M., and Kubagawa, H.: Genomic structure of PIR-B, the inhibitory member of the paired immunoglobulin-like receptor genes in mice. Tissue Antigens 51:224-231, 1998.


    Cucca, F., Zhu, Z-B., Khanna, A., Cossu, F., Congia, M., Badiali, M., Cao, A., Arnone, M., Piras, P., Campbell, D., Cooper, M. D., Volanakis, J., and Powis, S. H.: Evaluation of IgA deficiency in Sardinians indicates a susceptibility gene is encoded within the HLA class III region. Clin. Exp. Immunol. 111:76-80, 1998.


    Kong, F-k., Chen, C. H., and Cooper, M. D.: Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation. Immunity 8:97-104, 1998.


    Lin, Q., Taniuchi, I., Kitamura, D., Wang, J., Kearney, J. F., Watanabe, T., and Cooper, M. D.: T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice. J. Immunol. 160:4681-4687, 1998.


    Minegishi, Y., Coustan-Smith, E., Wang, Y-H., Cooper, M. D., Campana, D., and Conley, M. E.: Mutations in the human ¿5/14.1 gene result in B cell deficiency and agammaglobulinemia. J. Exp. Med. 187:71-77, 1998.


    Wang, Y-H., Nomura, J., Faye-Petersen, O. M., and Cooper, M. D.: Surrogate light chain production during B cell differentiation: Differential intracellular versus cell surface expression. J. Immunol. 161:1132-1139, 1998.


    Wang, J., Lin, Q., Wu, Q., and Cooper, M. D.: The enigmatic role of glutamyl aminopeptidase (BP-1/6C3 antigen) in immune system development. Immunol. Rev. 161:71-77, 1998.


    Horton, J. D., Horton, T. L., Dzialo, R., Gravenor, I., Minter, R., Ritchie, Gartland, L., Watson, M. D., and Cooper, M. D.: T-cell and natural killer cell development in thymectomized Xenopus. Immunol. Rev. 166:245-258, 1998.


    Conley, M. E. and Cooper, M. D.: Genetic basis of abnormal B cell development. Curr. Opin. Immunol. 10:399-406, 1998.


    Atkinson, T. P., Smith, C. S., Hsu, Y-M., Garber, E., Su, L., Howard, T. H., Prchal, J. T., Everson, M. P., and Cooper, M. D.: Leukocyte transfusion-associated granulocyte responses in a patient with X-linked hyper-IgM syndrome. J. Clin. Immunol. 18:430-439, 1998.


    Schroeder, H. W., Jr., Zhu, Z-B., March, R. E., Campbell, R. D., Berney, S. M., Nedospasov, S. A., Turetskaya, R. L., Atkinson, T. P., Go, R. C. P., Cooper, M. D. and, Volanakis, J. E.: Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes. Mol. Med. 4:72-86, 1998.


    Lin, Q., Dong, C., and Cooper, M. D.: Impairment of T and B cell development by treatment with a type I interferon. J. Exp. Med. 187:79-87, 1998.


    Dunon, D., Courtois, D., Vainio, O., Six, A., Chen, C. H., Cooper, M. D., Dangy, J. P. A., and Imhof, B. A.: Ontogeny of the immune system: ¿/¿ and ¿/¿ T cells migrate from thymus to the periphery in alternating waves. J. Exp. Med.186:977-988, 1997.


    Li, L., Wu, Q., Barnoski, B. L., and Cooper, M. D.: High resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP). Genomics 43:380-383, 1997.


    Thompson, A. A., Talley, J. A., Do, H. N., Kagan, L., Kunkel, L., Berenson, J., Cooper, M. D., Saxon, A., and Wall, R.: Aberrations of the B-cell receptor B29 (CD79b) gene in chronic lymphocytic leukemia. Blood 90:1387-1394, 1997.


    Johnson, M. L., Keeton, L. G., Zhu, Z.-B., Volanakis, J. E., Cooper, M. D., and Schroeder, H. W., Jr.: Age-related changes in serum immunoglobulins in patients with familial IgA deficiency and common variable immunodeficiency. Clin. Exp. Immunol. 108:477-483, 1997.


    Passer, B. J., Chen, C. H., Miller, N. W., and Cooper, M. D.: Catfish thrombocytes express an integrin-like CD41/CD61 complex. Exp. Cell Res.234:347-353, 1997.


    Dzialo, R. and Cooper, M. D.: An amphibian CD3 homologue of the mammalian CD3¿ and ¿ genes. Eur. J. Immunol. 27:1640-1647, 1997.


    Kubagawa, H., Burrows, P. D. and Cooper, M. D.: A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc. Natl. Acad. Sci. USA 94:5261-5266, 1997.


    Burrows, P. D. and Cooper, M. D.: IgA deficiency. Adv. Immunol. 65:245-276, 1997.


    Goitsuka, R., Chen, C. H., and Cooper, M. D.: B cells in the bursa of Fabricius express a novel C-type lectin gene. J. Immunol. 159:3126-3132, 1997.


    Su, D-M., Wang, J., Lin, Q., Cooper, M. D., and Watanabe, T.: Interferons ¿/¿ inhibit IL-7-induced proliferation of CD4! CD8- CD3- CD44+ CD25+ thymocytes, but do not inhibit that of CD4- CD8- CD3- CD44- CD25- thymocytes. Immunology 90:543-549, 1997.


    Burrows, P. D. and Cooper, M. D.: B cell development and differentiation. Curr. Opin. Immunol. 9:239-244, 1997.


    Paramithiotis, E. and Cooper, M. D.: Memory B lymphocytes migrate to the bone marrow in humans. Proc. Natl. Acad. Sci. USA 94:208-212, 1997.


    Haire, R. N., Ohta, Y., Strong, S. J., Litman, R. T., Liu, L., Prchal, J. T., Cooper, M. D., and Litman, G. W.: Unusual patterns of exon skipping in Bruton=s tyrosine kinase are associated with mutations involving the intron 17 3' splice site. Hum. Genet. 60:798-801, 1997.


    Lassoued, K., Illges, H., Benlagha, K., and Cooper, M. D.: Fate of surrogate light chains in B lineage cells. J. Exp. Med. 183:421-429, 1996.


    Prchal, J. T., Prchal, J. F., Belickova, M., Chen, S., Guan, Y., Gartland, G. L., and Cooper, M. D.: Clonal stability of blood cell lineages indicated by X-chromosomal transcriptional polymorphism. J. Exp. Med. 183:561-567, 1996.


    Wang, J., Taniuchi, I., Maekawa, Y., Howard, M., Cooper, M. D., and Watanabe, T.: Expression and function of FAS antigen on activated murine B cells. Eur. J. Immunol. 26:92-96, 1996.


    Tsuji, S., Char, D., Bucy, R. P., Simonsen, M., Chen, C. H., and Cooper, M. D.: ¿¿ T cells are secondary participants in acute graft-versus-host reactions initiated by CD4+ ¿¿ T cells. Eur. J. Immunol. 26:420-427, 1996.


    Nu¿ez, C., Nishimoto, N., Gartland, G. L., Billips, L. G., Burrows, P. D., Kubagawa, H., and Cooper, M. D.: B cells are generated throughout life in humans. J. Immunol. 156:866-872, 1996.


    Fujihashi, K., McGhee, J. R., Kweon, N-N., Cooper, M. D., Tonegawa, S., Takahashi, I. Hiroi, T., Mestecky, J., and Kiyono, H.: ¿¿ T cell deficient mice have impaired mucosal IgA responses. J. Exp. Med. 183:1929-1935, 1996.


    Wang, J., Walker, H., Lin, Q., Jenkins, N., Copeland, N. G., Watanabe, T., Burrows, P. D., and Cooper, M. D.: The mouse BP-1 gene: structure, chromosomal localization, and regulation of expression by type I interferons and interleukin-7. Genomics 3:167-176, 1996.


    Kuwahara, K., Kawai, T., Mitsuyoshi, S., Matsuo, Y., Kikunchi, H., Imajoh-Ohmi, S., Hashimoto, E., Inui, S., Cooper, M. D., and Sakaguchi, N.: Crosslinking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase. Int. Immunol. 8:1273-1285, 1996.


    G¿bel, T. W. F., Chen, C. H., and Cooper, M. D.: Expression of an avian CD6 candidate is restricted to ¿¿ T cells, splenic CD8+ ¿¿ T cells and embryonic NK cells. Eur. J. Immunol. 26:1743-1747, 1996.


    Dong, C., Willerford, D., Alt, F. W., and Cooper, M. D.: Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family. Immunogenetics 45:35-43, 1996.


    Passer, B. J., Chen, C. H., Miller, N. W., and Cooper, M. D.: Identification of a T lineage antigen in the catfish. Dev. Comp. Immunol. 20:441-450, 1996.


    Six, A., Rast, J. P., McCormack, W. T., Dunon, D., Courtois, D., Li, Y., Chen, C. H., and Cooper, M. D.: Characterization of avian T cell receptor ¿ genes. Proc. Natl. Acad. Sci. USA 93:15329-15334, 1996.


    Vihinen, M., Cooper, M. D., de Saint Basile, G., Fischer, A., Good, R. A., Hendriks, R. W., Kinnon, C., Kwan, S.-P., Litman, G. W., Notarangelo, L. D., Ochs, H. D., Rosen, F. S., Vetrie, D., Webster, A. D. B., Zegers, B. J. M., and Smith, C. I. E.: Btkbase - database of XLA causing mutations. Immunol. Today 16:460-465, 1995.


    Wang J, Lin Q, Langston H, Cooper MD: Resident bone marrow macrophages produce type I interferons that can selectively inhibit interleukin-7 driven growth of early B-lineage cells. Immunity 3:75-484, 1995.


    Chen, C. H., Kubota, T., Six, A., Tsuji, S., and Cooper, M. D.: Chicken T cell receptors. Bull. Soc. Fr.-Jpn. Sci Vet. 6:45-49, 1995.


    Bolognesi, D. P. and Cooper, M. D.: Immunodeficiency: Editorial overview. Curr. Opin. Immunol. 7:433-435, 1995.


    Lassoued K, Nunez CA, Billips L, Kubagawa H, Monteiro RC, LeBien TW, Cooper MD: Expression of surrogate light chain receptors is restricted to a late state in pre-B cell differentiation. Cell 73:1-20, 1993.


    Monteiro RC, Kubagawa H, Cooper MD: Cellular distribution, regula¿tion and biochemical nature of an Fca receptor in humans. J Exp Med 171:597-613, 1990.


    Bertoli LF, Kubagawa H, Borzillo GV, Burrows PD, Schreeder MT, Carroll AJ, Cooper MD: Bone marrow origin of a B cell lymphoma. Blood 72:94-101, 1988.


    Cooper MD, Mulvaney D, Coutinho A, Cazenave P-A: Identifi¿cation of a novel surface molecule on early B-lineage cells. Nature 321:616-618, 1986.


    Tedder TF, Cooper MD, Clement LT: Human lymphocyte differ¿entiation antigens HB-10 and HB-11. II. Differential production of cell growth and differenti¿a¿¿¿tion factors by distinct helper T cell subpopu¿lations. J Immunol 134:2989-2994, 1985.


    Levitt D, Cooper MD: Mouse pre-B cells synthesize and secrete m heavy chains but not light chains. Cell 19:617-625, 1980.


    Pearl ER, Vogler LB, Okos AJ, Crist WM, Lawton AR, Cooper MD: B lymphocyte precursors in bone marrow. An analysis of normal individuals and patients with antibody deficiency states. J Immunol 120:1169-1175, 1978.


    Vogler LB, Crist WM, Bockman DE, Pearl ER, Lawton AR, Cooper MD: Pre-B cell leukemia: A new phenotype of childhood lymphoblastic leukemia. N Engl J Med 298:872-878, 1978.


    Raff MC, Megson M, Owen JJT, Cooper MD: Early production of intracellu¿lar IgM by B lymphocyte precursors in mouse. Nature 259:224-226, 1976.


    Lydyard PM, Grossi CE, Cooper MD: Ontogeny of B cells in the chicken: I. Sequential development of clonal diversity in the bursa. J Exp Med 144:79-1976.


    Owen JJT, Cooper MD, Raff MC: In vitro generation of B lymphocytes in mouse foetal liver - a mammalian "bursa equivalent". Nature 249:361-363, 1974.


    Lawton AR, Asofsky R, Hylton MB, Cooper MD: Suppression of immunoglobulin class synthesis in mice: I. Effects of treatment with antibody to ¿ chain. J Exp Med 135:277-297, 1972.


    Kincade PW, Lawton AR, Bockman DE, Cooper MD: Suppression of immuno¿globulin G synthesis as a result of antibody-mediated suppression of immuno¿¿globulin M synthesis in chickens. Proc Natl Acad Sci USA 67:1918-1925, 1970.


    Cooper MD, Payne LN, Dent PB, Burmester BR, Good RA: Pathogenesis of avian lymphoid leukosis. J Natl Can Inst 41:373-390, 1968.


    Cooper MD, Peterson RDA, South MA, Good RA: The functions of the thymus system and the bursa system in the chicken. J Exp Med 123:75-102, 1966.


    Peterson RDA, Cooper MD, Good RA: The pathogenesis of immunologic deficiency diseases. Am J Med 38:579-604, 1965.


    Cooper MD, Peterson RDA, Good A: Delineation of the thymic and bursal lymphoid systems in the chicken. Nature 205:143-146, 1965.


    Book Chapters -

    Ehrhardt, G. R. A., Leu, C-M., Zhang, S., Aksu, G., Jackson, T., Haga, C., Hsu, J. T., Schreeder, D., Davis, R. S., and Cooper, M. D.: Fc receptor-like proteins (FCRL): immunomodulators of B cell function. In: Mechanisms of Lymphocyte Activation and Immune Regulation XI: B Cell Biology, S. Gupta, M. Cooper, K. Rajewsky, F. W. Alt, and F. Melchers, eds. Springer Publishers, NY., 2007. pp. 155-162.


    Schroeder, H. W. and Cooper, M. D.: Immunodeficiency diseases. In: Williams Hematology, 7th Edition, Chapter 82. M. A. Lichtman, E. Beutler, T. J. Kipps, U. Seligsohn, K. Kaushansky, and J. T. Prchal, eds. McGraw-Hill Publishers, 2006. pp. 1099-1107.


    Cooper, M. D. and Schroeder, H. W., Jr.: Primary immune deficiency diseases. In: Harrison's Principles of Internal Medicine, 16th Edition. D. L. Kasper, E. Braunwald, A. S. Fauci, S. L. Hauser, D. L. Longo, J. L. Jameson, eds. The McGraw-Hill Companies, Inc. , 2004. pp. 1939-1947.


    Wang, J. O. and Cooper, M. D.: Aminopeptidase A. In: Handbook of Proteolytic Enzymes. 2nd Edition. A. J. Barrett, N. Rawlings, and F. Woessner, eds. Academic Press, 2004. pp. 299-303.


    Burrows, P. D., LeBien, Tucker, Zhang, Z., Davis, R. S., and Cooper, M. D.: The development of human B lymphocytes. In: Molecular Biology of B Cells, Chapter 9. T. Honjo, F. W. Alt, and M. S. Neuberger, eds. Elsevier, Academic Press, London, 2004. pp. 141-154.


    Dennis, G., Jr., Kubagawa, H. and Cooper, M. D.: Paired immunoglobulin-like receptors. In: Wiley Encyclopedia of Molecular Medicine, Vol. 5. T. E. Creighton, ed. John Wiley & Sons, Inc., New York, 2002. pp. 2375-2378.


    Dennis, G., Jr., Chen, C-C., Kubagawa, H., and Cooper, M. D.: Phylogeny of paired Ig-like receptors. In: Activating and Inhibitory Immunoglobulin-like Receptors. M. D. Cooper, T. Takai and J. V. Ravetch, eds. Springer-Verlag, Tokyo, Japan, 2001. pp. 7-15.


    Cooper, M. D. and Schroeder, H. W., Jr.: Primary immune deficiency diseases. In: Harrison's Principles of Internal Medicine, 15th Edition. E. Braunwald, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, J. L., Jameson, eds. McGraw Hill Publishing, 2001. pp. 1843-1851.


    Wang, J., Chen, Y-F., Oparil, S., and Cooper, M. D.: Aminopeptidase A (APA/BP-1): an immunological overview. In: Cell-Surface Aminopeptidases: Basic and Clinical Aspects. S. Mizutani et al., eds. Elsevier Science B.V., Nagoya, Japan, 2001. pp. 75-84.


    Wang, J. and Cooper, M. D.: Glutamyl aminopeptidase. In: Handbook of Proteolytic Enzymes. F. Woessner, N. Rawlings, and Barrett, A. J., eds. Academic Press, 1998. pp. 1002-1005.


    Billips, L. G., Burrows, P. D. and Cooper, M. D.: The early B lymphocyte differentiation pathway in humans. In: The Handbook of Experimental Immunology, Vol. III, section 14, 5th Edition. D. M. Weir, L. A. Herzenberg, C. Blackwell, and Leonore A. Herzenberg, eds., 1997. pp. 85.1-85.7.


    Cooper, M. D. and Lawton, A. R., III: Primary immune deficiency diseases. In: Harrison's Principles of Internal Medicine, Chapter 307, 14th Edition. A. S. Fauci, E. Braunwald, K. J. Isselbacher, J. D. Wilson, J. B. Martin, D. L. Kasper, S. L. Hauser, and D. L. Longo, eds. McGraw-Hill, Inc., New York, 1997. pp. 1783-1791.


    Wang, J. and Cooper, M. D.: Structure and function of aminopeptidase A. In: Cell Surface-Peptidases in Health and Disease, Chapter 12. A. J. Kenny and C. M. Boustead, eds. BIOS Scientific Publishers, Oxford, 1997. pp. 193-202.


    Atkinson, T. P. and Cooper, M. D.: MMBID-7/E CD-ROM, Antibody deficiency diseases. In: The Metabolic and Molecular Bases of Inherited Disease, CD-ROM Seventh Edition. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, eds. McGraw-Hill Publishing Co., 1997.


    Cooper, M. D. and Burrows, P. D.: Overview: Acquired and genetic immunodeficiencies: Informative experiments of nature. In: The Handbook of Experimental Immunology, Vol. IV, section 27, 5th Edition. D. M.Weir, L. A. Herzenberg, C. Blackwell, and Leonore A. Herzenberg, eds., 1997. pp. 176.1-176.6.


    Cooper, M. D. and Haynes, B. F.: Diseases of the thymus. In: Cecil Textbook of Medicine, 21st Edition. J.C. Bennett and F. Plum, eds. W. B. Saunders Co., Philadelphia, 1996. pp. 1437-1439.


    Other Publications -

    Cooper, M. D. and Alder, M. N.: The evolution of adaptive immune systems. Cell (Review) 124:815-822, 2006.


    Pancer, Z., and Cooper, M. D.: The evolution of adaptive immunity. Ann. Rev. Immunol. 24:497-518, 2006


    Zhang, Z., Burrows, P. D., and Cooper, M. D.: The molecular basis and biological significance of VH replacement. Immunol. Rev. 197:231-242, 2004.


    Zhang, Z., Wang, Y-H., Zemlin, M., Findley, H. W., Bridges, S. L., Burrows, P. D., and Cooper, M. D.: Molecular mechanism of serial VH gene replacement. Ann. N.Y. Acad. Sci. 987:270-272, 2003.


    Davis, R. S., Dennis, G., Jr., Kubagawa, H., and Cooper, M. D.: Homologs FcRH1-5 extend the Fc receptor family. Curr. Top. Microbiol. Immunol. 266:85-112, 2002.


    Davis, R. S., Dennis, G., Jr., Odom, M. R., Gibson, A.W., Kimberly, R.P., Burrows, P. D., and Cooper, M. D.: Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family. Immunol. Rev. 190:123-136, 2002.


    Chen, C-C., Kang, D-W., Cooper, M. D., and Kubagawa, H.: Mast cell regulation via paired immunoglobulin-like receptor PIR-B. Immunol. Res. 26/1-3:191-198, 2002.


    Burrows, P. D., Stephan, R. P., Wang, Y-H., Lassoued, K., Zhang, Z., and Cooper, M. D.: The transient expression of pre-B cell receptors governs B cell development. Semin. Immunol. 14:343-349, 2002.


    Cooper, M. D.: Exploring lymphocyte differentiation pathways. Immunol. Rev. 185:175-185, 2002.


    Cooper, M., Dennis, G., Chen, C-C., Hurez, V., Tun, T., Alley, T., Ho, L-H., Uehara, T., Burrows, P., and Kubagawa, H.: Paired immunoglobulin-like receptors, PIR-A and PIR-B, and their phylogenetic relatives. In: 10th International Congress of Immunology, New Delhi, India, 1-6 November 1998. G. P. Talwar, I. Nath, N. K. Ganguly, and K. V. S. Rao, eds. S.p.A.-Bologna (Italy), 1998. pp. 3-9.