Pathology Faculty Member

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    1518 Clifton Rd 730 GCR
    Emory University
    Atlanta GA 30322
    404-778-0234 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Fred Sanfilippo, MD, PhD

    Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Professor, Health Policy and Management, Rollins School of Public Health

    Professor of Business Administration, Goizueta Business School

    Director, Emory Healthcare Innovation Program


    Pathology Division(s):
    Clinical Pathology
    Experimental Pathology


    Email Address:
    fred.sanfilippo@emory.edu


    Education:

    BA   University of Pennsylvania, - 1970

    MSc   University of Pennsylvania, - 1972

    PhD   Duke University, - 1975

    MD   Duke University, - 1976

    Residency   Anatomic and Clinical Pathology, 1976 - 1979

    Fellowship   Immunopathology, 1977 - 1979



    Research Interests:

    - Research Interests
    Dr. Sanfilippos research projects have included studies in solid state physics, molecular biology and immunogenetics, clinical trials, development of diagnostics and therapeutics, and mechanisms of allograft and xenograft rejection and acceptance. His major research interests in Pathology and Laboratory Medicine have been in immunopathology, transplantation biology, and renal pathology. His current major interests continue to focus on the application of informatics to enhance the quality of healthcare delivery at the level of individuals and populations, and enhancement of organizational performance and culture.



    Honors / Awards:

    Gold Humanism Honor Society, Arnold P. Gold Foundation, 2005

    Norman Cohn Hope Award, National Multiple Sclerosis Society, 2005

    John Minton Hero of Hope Research Champion Medal of Honor, American Cancer Society, 2005

    American Association for the Advancement of Science, Fellow, 2004

    Distinguished Alumnus Award, Duke University Medical Center, 2004

    Business Leader of the Year, Columbus Business First, 2003

    Senior Fellow, Association of Pathology Chairs, 2002

    Lya and Harrison Latta Lecture, UCLA, 1998

    MSTP Distinguished Scientist Lecture, University of Rochester, 1994

    Baxley Professor and Chair, John Hopkins Department of Pathology, 1993-2000

    Reach for Sight Physician Investigator Award, 1990

    Alpha Omega Alpha, National Medical Honor Society, 1987

    Wiley D. Forbus Award, North Carolina Society of Pathologists, 1979

    Kermit G. Osserman Award, Myasthenia Gravis Foundation, 1976

    Thomas Jefferson Award, Duke University School of Medicine, 1976

    Duke Endowment Award, King's Fund College, London, England, 1973

    NIH Predoctoral Fellowship: Medical Scientist Training Program, Duke University, 1970-76

    DFG Award, Max Planck Institute for Experimental Medicine, Gottingen, Germany, 1966-68

    Specialty Boards:

    1979  Anatomic and Clinical Pathology


    1983  Immunopathology


    Selected Publications:

    Published and Accepted Research Articles -

    Ota H, Fox-Talbot K, Hu W, Qian Z, Sanfilippo F, Hruban RH, Baldwin WM: Terminal complement components mediate release of von Willebrand factor and adhesion of platelets in arteries of allografts. Transplantation 2005; 79:276-281.


    Wasowska BA, Qian Z, Cangello DL, Behrens E, Elshimi T, van Tran T, Hu W, Sanfilippo, F, Baldwin W: Passive transfer of alloantibodies restores acute allograft rejection in IgKO mice. Transplantation 2001; 71: 727-736.


    Qian Z, Wasowska B, Sanfilippo F, Baldwin WM: Hepatic source of C6 drives complement-mediated cardiac allograft injury. J Heart Lung Transplant. 2001; 20:227.


    Baldwin, WM, Qian Z, Ota H, Hu W, Samaniego M, Wasowska B, Sanfilippo F, Hruban RH: Complement as a mediator of vascular inflammation and activation in allografts. J Heart Lung Transplant. 2000;19:723-730.


    Baldwin WM, Samaniego-Picota M, Kasper EK, Clark A, Czader M, Rohde C, Zachary AA, Sanfilippo F, Hruban H: Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes. Transplantation 1999; 68:894-900.


    Qian Z, Wasowska B, Behrens E, Brody J, Kadkol S, Horwitz L, Liu J, Lowenstein C, Hess A, Sanfilippo F, Baldwin WM: C6 produced by macrophages contributes to cardiac allograft rejection. A J Pathol 1999; 155:1293-1302.


    Moldovan NI, Qian Z, Chen Y, Dong C, Ying A, Hruban R, Flavahan NA, Baldwin WM, Sanfilippo F, Goldschmidt-Clermont PJ: Fas-mediated apoptosis in accelerated graft arteriosclerosis. Angiogenesis 1998; 2:245-254.


    Jakobs FM, Davis, EA, Qian Z, Liu DY, Baldwin WM, Sanfilippo F: The role of CD11b/CD18 mediated neutrophil adhesion in complement deficient xenograft recipients. Clin. Transplant 1997; 11:516.


    Davis EA, Pruitt SK, Greene PS, Ibrahim S, Lam TT, Levin JL, Baldwin WM, Sanfilippo F: Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xenografts. Transplantation 1996; 62:1018-1023.


    Epstein JI, Walsh PC, Sanfilippo F: Clinical and cost impact of second-opinion pathology. Review of prostate biopsies prior to radical prostatectomy. Amer. J. Surg. Path. 1996; 20:851-857.


    Ibrahim S, Jacobs F, Kittur D, Lindsley P, Hess A, Sanfilippo F, Baldwin WM: CTLA4Ig inhibition of alloantibody responses to repeated blood transfusions. Blood 1996; 88: 4594-4600.


    Hahn AB, Foulks GN, Enger C, Fink N, Stark WJ, Hopkins KA, Sanfilippo F: The association of lymphocytotoxic antibodies with corneal allograft rejection in high-risk patients. Transplantation 1995; 59: 21-27.


    Ibrahim S, Dawson DV, Sanfilippo F: Predominant infiltration of rejecting human renal allografts with T cells expressing CD8 and CD45RO. Transplantation 1995; 59:724-728.


    Brauer RB, Baldwin, WM, Wang D, Horwitz LR, Hess AD, Klein AS, Sanfilippo F: Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat. J. Immunol. 1994; 153: 3168-76.


    Howell DN, Ross JR, Miller SE, Sanfilippo F: Characterization of a novel family of ciliary body glycoproteins. Invest. Ophthal. Vis. Sci. 1994; 35:3308-3318.


    Howell DN, Ahuja V, Jones L, Blow O, Sanfilippo FP: Differential expression of CD43 (leukosialin, sialophorin) by mononuclear phagocyte populations. J. Leukocyte Biol. 1994; 55:536-544.


    Pruitt SK, Kirk AD, Bollinger RR, Marsh HC, Collins BH, Levin JL, Mault JR, Heinle JS, Ibrahim S, Rudolph AR, Baldwin WM, Sanfilippo F: The effect of soluble complement receptor Type 1 on hyperacute rejection of porcine xenografts. Transplantation 1994; 57: 363-370.


    Coffman T, Geier S, Ibrahim S, Griffiths R, Spurney R, Smithies O, Koller B, Sanfilippo F: Improved renal function in mouse kidney allografts lacking MHC class I antigens. J. Immunol. 1993; 151:425-435.


    Kirk AD, Heinle JS, Mault JR, Sanfilippo F: Ex vivo characterization of human anti-porcine hyperacute cardiac rejection. Transplantation 1993; 56:785-793.


    Ibrahim S, Dawson DV, Van Trigt P, Sanfilippo F: Differential infiltration by CD45RO and CD45RA subsets of T cells associated with human heart allograft rejection. Am J Pathol. 1993; 142:1794-1803.


    Sanfilippo F, Vaughn WK, Peters TG, Adams PL, Lorber MI, Williams GM: Factors affecting the waiting time of cadaveric kidney transplant candidates in the United States. J.A.M.A. 1992; 267:247-252.


    Emara M, Sanfilippo F: The inhibition of T cell proliferative responses by crosslinking CD7 and IgM-Fc receptors. Cellular Immunology 1992; 144:143-154.


    Downey WE, Baldwin WM, Sanfilippo F: Association of donor-specific blood transfusion enhancement of rat renal allografts with accelerated development of antiidiotypic antibodies and reduced alloantibody responses. Transplantation 1990; 49:160-166.


    Ruiz P, Coffman TM, Klotman PE, Sanfilippo F: Association of chronic thromboxane inhibition with reduced in situ cytotoxic T cell activity in rejecting rat renal allografts. Transplantation 1989; 48:660-666.


    Ruiz P, Coffman TM, Howell DN, Straznickas J, Scroggs MW, Baldwin WM, Klotman PE, Sanfilippo F: Evidence that pretransplant donor blood transfusion prevents rat renal allograft dysfunction but not the in situ cellular alloimmune or morphologic manifestations of rejection. Transplantation 1988; 45:1-7.


    Ruiz P, Kolbeck PC, Scroggs MW, Sanfilippo F: Associations between cyclosporine therapy and interstitial fibrosis in renal allograft biopsies. Transplantation 1988; 45:91-95.


    Sanfilippo F, MacQueen JM, Vaughn WK, Foulks GN: Reduced graft rejection with good HLA-A and B matching in high-risk cornea transplantation. N. Engl. J. Med. 1986; 315:29-35.


    Treseler PA, Foulks GN, Sanfilippo F: The expression of HLA antigens by cells in the human cornea. Am. J. Ophthalmol. 1984; 98:763-772.


    Sanfilippo F, Vaughn WK, Spees EK, Light JA, LeFor WM: Benefits of HLA-A and HLA-B matching on graft and patient outcome after cadaveric-donor renal transplantation. N. Engl. J. Med. 1984; 311:358-364.


    Book Chapters -

    Borowitz M and Sanfilippo F: The Role of Pathology and Laboratory Medicine in the Diagnosis of Cancer. In: Clinical Oncology 3rd Edition (M Abeloff et al, eds) Elsevier, NY; 2004:299-339.


    Baldwin WM and Sanfilippo F: Xenograft Transplantation. In: Heart and Lung Transplantation, 2nd Ed. (WA Baumgartner, BA Reitz, E Kasper, J Theodore, eds.). WB Saunders, Orlando; 2001:521-530.


    Baldwin WM and Sanfilippo F: Xenograft Transplantation. In: Heart and Lung Transplantation, 2nd Ed. (WA Baumgartner, BA Reitz, E Kasper, J Theodore, eds.). WB Saunders, Orlando; 2001:521-530.


    Foulks GN, Sanfilippo F: The Role of Corneal Antigens in Graft Success or Failure. In: Corneal Surgery 3rd Edition (FS Brightbill, ed.). C. V. Mosby, St. Louis; 1999:906-913.


    Epstein J, Sanfilippo F, eds: The Johns Hopkins Atlas of Surgical Pathology. Elsevier, NY; 1999.


    Hruban RH, Baldwin WM, Sanfilippo F: Immunopathology of Rejection. In: Solid Organ Transplant Rejection: Mechanisms, Pathology, and Diagnosis (K Solez, L Racusen, ME Billingham, eds.). Marcel Dekker, N.Y.; 1996: 59-75.


    Hruban RH, Baldwin WM, Sanfilippo F: Immunopathology of Rejection. In: Solid Organ Transplant Rejection: Mechanisms, Pathology, and Diagnosis (K Solez, L Racusen, ME Billingham, eds.). Marcel Dekker, N.Y.; 1996: 59-75.


    Sanfilippo F: The Role and Methods of Histocompatibility Testing in Transplantation. In: Transplant Pathology (PC Kolbeck, RS Markin, BM McManus, eds.). ASCP Press, Chicago; 1994:19-44.


    Sanfilippo F, Balber A, Granger D, McKinney R: Immune Response to Infection. In: Zinsser Microbiology, 20th Edition (WK Joklik, HP Willett, DB Amos, K Wilfert, eds.). Appleton and Lange, NY; 1992:345-368.


    Sanfilippo F, Baldwin WM, Snyderman R: Immunopathology. In: Zinsser Microbiology, 20th Edition (WK Joklik, HP Willett, DB Amos, K Wilfert, eds.). Appleton and Lange, NY; 1992:311-326.


    Amos DB and Sanfilippo F: The Immunology of Transplantation Antigens. In: Textbook of Surgery, 14th Edition (DC Sabiston, ed.). Saunders, NY; 1991:345-356.


    Sanfilippo F and Amos DB: Mechanisms and Characteristics of Allograft Rejection. In: Textbook of Surgery, 14th Edition (DC Sabiston, ed.). Saunders, NY; 1991:357-373.


    Sanfilippo F: Renal Transplantation. In: The Pathology of Organ Transplantation (GE Sale, ed.). Butterworths, London; 1990:51-101.


    Sanfilippo F: The Use of Non-human Primates in Xenotransplantation. In: Xenograft-25 (M Hardy, ed.). Elsevier, NY; 1989:171-178.


    Other Publications -

    Sanfilippo F: Academic Health Centers. In: Engineering the Health System. (WB Rouse, D Cortese, eds). IOS Press; 2010: 383-414.


    Sanfilippo F, Bendapudi N, Rucci A, Schlesinger L: Strong Leadership and Teamwork Drive Culture and Performance Change: Ohio State University Medical Center 2000-2006. Academic Medicine 2008; 83:845-854.


    Bissell M and Sanfilippo F: Empowering patients with point-of-care testing. Trends in Biotechnol 2002; 20(6):269-270.


    Sanfilippo F: Transplantation tolerance - the search continues. (Invited Editorial) N Engl J Med 1998; 339: 1700-1702.


    Sanfilippo F: HLA matching in renal transplantation (Invited Editorial). N. Engl. J. Med. 1994; 331:803-805.