Pathology Faculty Member

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    Yerkes National Primate Research Center
    954 Gatewood Road, NE
    Atlanta, GA 30329
    404-727-9840 Phone

    For an expert Pathology consultation,
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    Mirko Paiardini, PhD

    HIV Pathogenesis

    Associate Professor
    Pathology & Laboratory Medicine

    Pathology Faculty Photo

    Other Appointments/Positions

    Associate Professor, Yerkes National Primate Research Center

    Pathology Division(s):
    Experimental Pathology

    Email Address:


      Instituto Tecnico Commerciale e per Geometri, Urbania, Italy, - 1990

    B.S. Biology   University of Urbino, Italy, - 1996

    Ph.D. Biochemistry & Pharmacology   University of Urbino, Italy, - 2003

    Research Interests:

    - HIV Pathogenesis and Cure
    My research focuses on studies of HIV pathogenesis and cure. Using both humans and nonhuman primates, we aim to (i) define the causes of residual inflammation in ART-treated HIV/SIV infection, (ii) define the anatomic and phenotypical nature of the HIV reservoir, and (iii) design interventions to target inflammation and HIV persistence

    Honors / Awards:

    Emory 1% Award, to recognize faculty scoring in the top one-percentile on a federal grant application, 2013

    Emory University Research Committee and Atlanta Clinical & Translational Science Institute Pilot Award, 2012

    Italian Consorzio Interuniversitario Biotecnologie, Fellowship Award, 2005

    Italian Minister of Health, Fellowship Award for AIDS Research, 2004

    Italian Minister of Health, Fellowship Award for AIDS Research, 2003

    Fellow Travel Grant Awardees, AIDS Vaccine, 2003

    Italian Consorzio Interuniversitario Biotecnologie, Fellowship Award, 2002

    Selected Publications:

    Published and Accepted Research Articles -

    McGary C, Alvares X, Harrington S, Cervasi B, Ryan E, Iriele R, Paganini S, Harper J, Easley K, Silvestri G, Ansari A, Lichterfeld M, Micci L, Paiardini M. The loss of CCR6+ and CD161+ CD4+ T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques. 2017. Mucosal Immunol, Jan 4. doi: 10.103/mi.2016.116. PMID: 28051083 Epub ahead of print.

    Ortiz AM, Klase ZA, DiNapoli SR, Vujkovic-Cvijin I, Carmack K, Perkins MR, Calantone N, Vinton CL, Riddick NE, Gallagher J, Klatt NR, McCune JM, Estes JD, Paiardini M, Brenchley JM. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. 2016. Mucosal Immunol, 9: 458-67.

    Panigrahi S, Freeman ML, Funderburg NT, Mudd JC, Younes SA, Sieg SF, Zidar DA, Paiardini M, Villinger F, Calabrese LH, Ransohoff RM, Jain MK, Lederman MM. SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction. J Infect Dis, 213: 1419-27.

    Ryan ES, Micci L, Fromentin R, Paganini S, McGary CS, Easley K, Chomont N, Paiardini M. Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques. PLoS Pathog.2016 Feb 112(2):e1005412. doi: 10.1371/journal.ppat.1005412. eCollection 2016 Feb. PMID: 26829644

    Paiardini M, Lichterfeld M. Follicular T helper cells: hotspots for HIV-1 persistence. Nat Med. 2016 Jul 7;22(7):711-2. doi: 10.1038/nm.4138. PMID: 27387885

    Claiborne DT, Prince JL, Scully E, Macharia G, Micci L, Lawson B, Kopycinski J, Deymier MJ, Vanderford TH, Nganou-Makamdop K, Ende Z, Brooks K, Tang J, Yu T, Lakhi S, Kilembe W, Silvestri G, Douek D, Goepfert PA, Price MA, Allen SA, Paiardini M, Altfeld M, Gilmour J, Hunter E. Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression. 2015. Proc Natl Acad Sci USA, 112(12):E1480-89.

    Micci L, Ryan E, Fromentin R, Bosinger S, Paganini S, Easley K, McGary C, Rogers K, Apetrei C, Estes J, Lifson J, Chomont N, Villinger F, Silvestri G, Brenchley J, Paiardini M. Interleukin-21 decreases residual inflammation and reduces the viral reservoir in ART-treated, SIV-infected rhesus macaques. 2015. J Clin Invest, 125:4497-513.

    Carnathan DG, Wetzel KS, Yu J, Lee ST, Johnson BA, Paiardini M, Yan J, Morrow MP, Sardesai NY, Weiner DB, Ertl HC, Silvestri G. Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques. 2015. Proc Natl Acad Sci U S A, 112:518-523.

    Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M Jr, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M. Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.J Clin Invest. 2015 Dec;125(12):4497-513. doi: 10.1172/JCI81400. Epub 2015 Nov 9. PMID: 26551680

    Chowdhury A, Hayes TL, Bosinger SE, Lawson BO, Vanderford T, Schmitz JE, Paiardini M, Betts M, Chahroudi A, Estes JD, Silvestri G. Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques. 2015. J Virol, 89: 8677-86.

    Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG. Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV. 2015. J Virol, 89: 9252-61.

    Mir KD, Mavigner M, Wang C, Paiardini M, Sodora DL, Chahroudi AM, Bosinger SE, Silvestri G. Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors. 2015. J Virol, 89: 10136-44.

    Micci L, McGary CS, Paiardini M. Animal models in HIV cure research. 2015. Journal of Virus Eradication, 1:17-22.

    d'Ettorre G, Baroncelli S, Micci L, Ceccarelli G, Andreotti M, Sharma P, Fanello G, Fiocca F, Cavallari EN, Giustini N, Mallano A, Galluzzo CM, Vella S, Mastroianni CM, Silvestri G, Paiardini M, Vullo V. Reconstitution of Intestinal CD4 and Th17 T Cells in Antiretroviral Therapy Suppressed HIV-Infected Subjects: Implication for Residual Immune Activation from the Results of a Clinical Trial. 2014. PLOS One, 9: e109791

    Cartwright EK, McGary CS, Cervasi B, Micci L, Lawson B, Elliott ST, Collman RG, Bosinger SE, Paiardini M, Vanderford TH, Chahroudi A, Silvestri G. Divergent CD4+ T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections. 2014. J Immunol, 192:4666-4673.

    McGary C, Cervasi B, Micci L, Else J, Silvestri G, Meeker T, Davenport M, Paiardini M. Increased stability and reduced proliferation of CD4+ central memory T cells differentiate non-progressive SIV-infection of sooty mangabeys from progressive SIV-infection of rhesus macaques. 2014. J Virol, 88:4533-4542.

    McGary CS, Silvestri G, Paiardini M. Animal models for viral infection and cell exhaustion. 2014. Curr Opin HIV AIDS, 9:492-499.

    Micci L, Alvarez X, Iriele RI, Ortiz AM, Ryan ES, McGary CS, Deleage C, McAtee BB, He T, Apetrei C, Easley K, Pahwa S, Collman RG, Derdeyn CA, Davenport MP, Estes JD, Silvestri G, Lackner AA, Paiardini M. CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells. PLoS Pathog. 2014 Oct 30;10(10):e1004467. doi: 10.1371/journal.ppat.1004467. eCollection 2014 Oct. PMID: 25356757

    Sundaravaradan V, Saleem R, Micci L, Gasper MA, Ortiz AM, Else J, Silvestri G, Paiardini M, Aitchison JD, Sodora DL. Multifunctional double-negative T cells in sooty mangabeys Mediate T-helper functions irrespective of SIV infection. 2013. PLoS Pathogens, 9:e1003441.

    Cervasi B, Carnathan D, Sheehan K, Micci L, Paiardini M, Raj K, Tuyishime S, Zhou XY, Else JG, Ratcliffe SJ, Ertl HC, Silvestri G. Immunological and virological analyses of rhesus macaques immunized with chimpanzee adenoviruses expressing SIVgag/tat and challenged intra-rectally with repeated low-dose of SIVmac. 2013. J Virol, 87:9420-9430

    Francella N, Gwyn SE, Yi Y, Li B, Xiao P, Elliott ST, Ortiz AM, Hoxie JA, Paiardini M, Silvestri G, Derdeyn CA, Collman RG. CD4+ T cells support production of SIV Env antibodies that enforce CD4-dependent entry and shape tropism in vivo. 2013. J Virol, 87:9719-9732.

    Tabb B, Morcock DR, Trubey CM, Quiñones OA, Hao XP, Smedley J, Macallister R, Piatak M Jr, Harris LD, Paiardini M, Silvestri G, Brenchley JM, Alvord WG, Lifson JD, Estes JD. Reduced Inflammation and Lymphoid Tissue Immunopathology in Rhesus Macaques Receiving Anti-Tumor Necrosis Factor Treatment During Primary Simian Immunodeficiency Virus Infection. 2013. J Infect Dis, 207:880-892.

    Paiardini, M, Muller-Trutwin M. HIV-associated chronic immune activation. 2013. Immunol Rev, 254:78-101.

    Pallikkuth S, Micci L, Ende Z, Iriele R, Cervasi B, McGary C, Lawson B, Else J, Silvestri G, Villinger F, Pahwa S, Paiardini M. Maintenance of intestinal Th17 cells and reduced microbial Translocation in SIV-infected rhesus macaques treated with Interleukin (IL)-21. 2013. PLoS Pathogens, 9:e1003471.

    Francella N, Elliott ST, Yi Y, Gwyn SE, Ortiz AM, Li B, Silvestri G, Paiardini M, Derdeyn CA, Collman RG. Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo. 2013. Retrovirology, 10:133

    Elliott ST, Riddick NE, Francella N, Paiardini M, Vanderford TH, Li B, Apetrei C, Sodora DL, Derdeyn CA, Silvestri G, Collman RG. Cloning and Analysis of Sooty Mangabey Alternative Coreceptors That Support Simian Immunodeficiency Virus SIVsmm Entry Independently of CCR5. 2012. J Virol, 86:898-908.

    Klatt NR, Estes JD, Sun X, Ortiz AM, Barber JS, Harris LD, Cervasi B, Yokomizo LK, Pan L, Vinton CL, Tabb B, Canary LA, Dang Q, Hirsch VM, Alter G, Belkaid Y, Lifson JD, Silvestri G, Milner JD, Paiardini M, Haddad EK, Brenchley JM. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. 2012. Mucosal Immunol, 5:646-657.

    Zeng M, Paiardini M, Engram JC, Beilman GJ, Chipman JG, Schacker TW, Silvestri G, Haase AT. Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution. 2012. Blood, 120:1856-1867. PMID: 22613799, PMCID: PMC3433090.

    Brenchley JM, Vinton C, Tabb B, Hao X, Connick E, Paiardini M, Lifson J, Silvestri G, Estes JD. Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. 2012. Blood, 120:4172-4181.

    Micci L, Cervasi B, Ende ZE, Iriele R, Reyes-Aville E, Vinton C, Else J, Silvestri G, Ansari A, Villinger F, Pahwa S, Estes JD, Brenchley JM, Paiardini M. Paucity of Interleukin (IL-21)- Producing CD4+ T-Cells is associated with Th17 cell depletion in SIV-Infection of Rhesus Macaques. 2012. Blood, 120:3925-3935.

    Chahroudi A, Bosinger SE, Vanderford TH, Paiardini M, Silvestri G. Natural SIV hosts: showing AIDS the door. Science. 2012 Mar 9;335(6073):1188-93. doi: 10.1126/science.1217550. Review. Erratum in: Science. 2012 Apr 27;336(6080):413. PMID: 22403383

    D'Ettore G, Douek D, Paiardini M, Ceccarelli G, Vullo V. Microbial translocation and infectious diseases: what is the link? 2012. Int J Microbiol, 2012:356981

    Brenchley J, Paiardini M. Immunodeficiency lentiviral infections in natural and nonnatural hosts. 2011. Blood, 118:847-854.

    Paiardini M. Hijacking the IL-7/IL-7R system in HIV infection. 2011. Editorial, J Leukoc Biol, 89:491-49.

    D'Ettore G, Paiardini M, Ceccarelli G, Silvestri G, Vullo V. HIV-associated immune activation: from bench to bedside. 2011. AIDS Res Hum Retroviruses, 27:335-364.

    Ortiz AM, Klatt NR, Li B, Yi Y, Tabb B, Hao XP, Sternberg L, Lawson B, Carnathan PM, Cramer EM, Engram JC, Little DM, Ryzhova E, Gonzalez-Scarano F, Paiardini M, Ansari AA, Ratcliffe S, Else JG, Brenchley JM, Collman RG, Estes JD, Derdeyn CA, Silvestri G. Depletion of CD4¿ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. 2011. J Clin Invest, 121:4433-4445.

    M. Paiardini*, B. Cervasi, E. Reyes-Aviles, L. Micci, AM. Ortiz, A. Chahroudi, C. Vinton, SN. Gordon, SE. Bosinger, N. Francella, PL. Hallberg, E. Cramer, T. Schlub, ML. Chan, NE. Riddick, RG. Collman, C. Apetrei, I. Pandrea, J. Else, J. Munch, F. Kirchhoff, MP. Davenport, JM. Brenchley, G. Silvestri*. Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression. 2011. Nat Med, 17:830-836. *Co-corresponding authors.

    G. d'Ettorre, M. Paiardini, L. Zaffiri, M. Andreotti, G. Ceccarelli, C. Rizza, M. Indinnimeo, S. Vella, CM. Mastroianni, G. Silvestri, V. Vullo. HIV persistence in the gut mucosa of HIV- infected subjects undergoing antiretroviral therapy correlates with immune activation and increased levels of LPS. 2011. Curr HIV Res, 19:148-153.

    G. Visalli, M. Paiardini, C. Chirico, B. Cervasi, M. Curró, N. Ferlazzo, MP. Bertuccio, A. favaloro, G. Pellicanó, G. Sturniolo, P. Spataro, R. Ientile, I. Picerno, G. Piedimonte. Intracellular accumulation of cell cycle regulatory proteins and nucleolin re-localization are associated with pre-lethal ultrastructural lesions in circulating T lymphocytes: The HIV-induced cell cycle dysregulation revisited. 2010. Cell Cycle,

    ML. Chan, J. Petravic, AM. Ortiz, J. Engram, M. Paiardini, D. Cromer, G. Silvestri, MP. Davenport. Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys. Proc Biol Sci, 2010 Dec 22;277(1701):3773- 3781.

    SN. Gordon, B. Cervasi, P. Odorizzi, R. Silverman, F. Aberra, G. Ginsberg, JD Estes, M. Paiardini, I. Frank, Silvestri G. Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals. 2010. J Immunol, 185:5169-517.

    Riddick NE, Hermann EA, Loftin LM, Elliott ST, Wey WC, Cervasi B, Taaffe J, Engram JC, Li B, Else JG, Li Y, Hahn BH, Derdeyn CA, Sodora DL, Apetrei Paiardini M, Silvestri G, Collman RG. A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo. PLoS Patholog. 2010 Aug

    NR. Klatt, E. Shudo, AM. Ortiz, JC. Engram, M. Paiardini, B. Lawson, MD. Miller, J. Else, I. Pandrea, JD. Estes, C. Apetrei, JE. Schmitz, RM. Ribeiro, AS. Perelson, G. Silvestri. CD8+ Lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the life span of productively infected cells. PLoS Pathog. 2010 Jan 29:6(1):e:10000747

    J. Taaffe, A. Chahroudi, J. Engram, B. Sumpter, T. Meeker, S. Ratcliffe, M. Paiardini, J. Else, Silvestri. A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation. 2010. J Virol, 4:5476-5484.

    LD Harris, B. Tabb, DL. Sodora, M. Paiardini, NR. Klatt, DC. Douek, G. Silvestri, M.Müller-Trutwin, I. Vasile-Pandrea, C. Apetrei, V. Hirsch, J. Lifson, JM. Brenchley, JD. Estes. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques. 2010. J Virol, 84:7886-7891.

    JD. Estes, LD. Harris, NR. Klatt, B. Tabb, S. Pittaluga, M. Paiardini, GR. Barclay, J. Smedley, R. Pung, KM. Oliveeira, VM. Hirsch, G. Silvestri, DC. Douek, CJ. Miller, AT.Haase, J. Lifson, JM. Brenchley. Damaged intestinl epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. 2010. PLos Pathog. 6:e1001052.

    J.C. Engram, RM. Dunham, G. Makedonas, TH. Vanderford, B. Sumpter, NR. Klatt, SJ Ratcliffe, S. Garg, M. Paiardini, M. McQuoid, JD Altman, SI Staprans, MR Betts, DA. Garber, MB. Feinberg, G. Silvestri. Vaccine-induced, Simian Immunodeficiency Virus-specific CD8+ T cells reduce virus replication but do not protect from Simian Immunodeficiency Virus disease progression. 2009. J Immunol, 183:706-717

    M. Paiardini, J. Hoffman, B. Cervasi, AM. Ortiz, F. Stroud, G. Silvestri, ME. Wilson. T- cell phenotypic and functional changes associated with social subordination and gene polymorphisms in the serotonin reuptake transporter in female rhesus monkeys. 2009. Brain Behav Immunol, 23:286-293

    M. Paiardini, B. Cervasi, J. Engram, S.N. Gordon, N.R. Klatt, A. Muthukumar, J. Else, R.S. Mittler, S.I. Staprans, D.L. Sodora, G. Silvestri. Bone marrow-based homeostatic proliferation of mature T-cells in non-human primates: implications for AIDS pathogenesis. 2009. Blood, 113:612-621.

    SE. Bosinger, SN. Gordon, NR. Klatt, L. Xu, A. Sidahmed2, L. Ran, TH. Vanderford, M. Paiardini, RB. Isett, DA. Baldwin, JG. Else, SI. Staprans, G. Silvestri, DJ. Kelvin. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected Sooty Mangabeys. 2009. J Clin Invest, 119:3556-3572, PMID: 19959874, PMCID: PMC2786806

    Paiardini M, Pandrea I, Apetrei C, Silvestri G. Lessons Learned from the Natural Hosts of HIV-related Viruses. 2009. Ann Rev Med, 60-485-495.

    J.M. Brenchley*, M. Paiardini*, K.S. Knox, A.I. Asher, B. Cervasi, T.E. Asher, P. Scheinberg, D.A. Price, C.A. Hage, L.M. Kholi, A. Khoruts, I. Frank, J. Else, T. Schacker, G. Silvestri, D.C. Douek. Differential Th17 CD4 T cell depletion in pathogenic and nonpathogenic lentiviral infections. 2008. Blood, 112:2826-2835. *Contributed equally

    Paiardini M, Cervasi B. Immunology of SIV infection in natural hosts. Implication for HIV pathogenesis. 2008. Future HIV Therapy, 2:603-611.

    Paiardini M, Frank I, Pandrea I, Apetrei C, Silvestri G. Mucosal immune dysfunction in AIDS pathogenesis. 2008. AIDS Rev, 10:36-46.

    R.M. Dunham, B. Cervasi, J. Brenchley, H. Albrecht, A. Weintrob, B. Sumpter, J. Engram, S. Gordon, N. Klatt, D. Sodora, D. Douek, M. Paiardini, G. Silvestri. CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. 2008. J Immunol, 180:5582-5592.

    S.N. Gordon, R.M. Dunham, J.C. Engram, J. Estes, Z. Wang, N.R. Klatt, M. Paiardini, I.V. Pandrea, C. Apetrei, D.L. Sodora, H.Y. Lee, A.T. Haase, M.D. Miller, A. Kaur, S.I. Staprans, A.S. Perelson, M.B. Feinberg, G. Silvestri. Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implication for AIDS pathogenesis. 2008. J Virol, 82:3725-3735.

    Silvestri G, Paiardini M, Pandrea I, Lederman M.M., Sodora D.L. Understanding the benign nature of SIV infection in natural hosts. 2007. J Clin Invest, 117:3148-3154.

    J.M. Milush, J.D. Reeves, S.N. Gordon, D. Zhou, A. Muthukumar, D.A. Kosub, E. Chacko, L.D. Giavedoni, C.C. Ibegbu, K.S. Cole, J.L. Miamidian, M. Paiardini, A.P. Barry, S.I. Staprans, G. Silvestri, D.L. Sodora. Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host. 2007. J Immunol, 179:3047-3056

    S.N. Gordon, N.R. Klatt, S.E. Bosinger, J.M. Brenchley, J.M. Milush, J.C. Engram, R.M. Dunham, M. Paiardini, S. Klucking, A. Danesh, E.A. Strobert, C. Apetrei, I.V. Pandrea, D. Kelvin, D.C. Douek, S.I. Staprans, D.L. Sodora, G. Silvestri. Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. 2007. J Immunol, 179:3026-3034

    B. Sumpter, R. Dunham, S. Gordon, J. Engram, M. Hennessy, A. Kinter, M. Paiardini, B. Cervasi, N. Klatt, H. McClure, J.M. Milush, S. Staprans, D.L. Sodora, G. Silvestri. Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis. 2007. J Immunol, 178:1680-1691

    M. Magnani, M. Paiardini, B. Cervasi, S. Serafini, A. Fraternale, G. Silvestri. Fludarabine delivery by autologous res blood cells induces macrophage depletion in chronically SIV-infected Sooty Mangabeys. 2006. J Control Release, 116:e45-47.

    B. Cervasi, M. Paiardini, S. Serafini, A. Fraternale, M. Menotta, J. Engram, B. Lawson, S.I. Staprans, G. Piedimonte, C.F. Perno, G. Silvestri, M. Magnani. Administration of fludarabine-loaded autologous red blood cells in SIV infected sooty mangabeys depletes pSTAT-1 expressing macrophages and delays the rebound of viremia after suspension of antiretroviral therapy. 2006. J Virol, 80:10335-10345.

    M. Paiardini, B. Cervasi, B. Sumpter, H.M. McClure, D.L. Sodora, M. Magnani, S.I. Staprans, G. Piedimonte, G. Silvestri. Perturbations of cell cycle control in T cells contribute to the different outcomes of SIV infection in rhesus macaques and sooty mangabeys. 2006. J. Virol, 80:634-642.

    R. Dunham, P. Pagliardini, S. Gordon, B. Sumpter, J. Engram, A. Moanna, M. Paiardini, J.N. Mandl, B. Lawson, S. Garg, H.M. McClure, Y.X. Xu, C. Ibegbu, K. Easley, N. Katz, I. Pandrea, C. Apetrei, D.L. Sodora, S.I. Staprans, M.B. Feinberg, G. Silvestri. The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus. 2006. Blood, 108:209-217.

    Moanna A, Dunham R, Paiardini M, Silvestri G. CD4+ T-cell depletion in HIV infection: killed by friendly fire? 2005. Curr HIV/AIDS Rep, 2:16-23.

    A. Muthukumar, D. Zhou, M. Paiardini, A.P. Barry, K.S. Cole, H.M. McClure, S.I. Staprans, G.Silvestri, D.L. Sodora. Timely triggering of homeostatic mechanisms involved in the regulation of T cell levels in SIVsm infected sooty mangabeys. 2005. Blood, 106:3839-3845.

    M. Paiardini, B. Cervasi, H. Albrecht, A. Muthukumar, R. Dunham, S. Gordon, H. Radziewicz, G. Piedimonte, M. Magnani, M. Montroni, S.M. Kaech, A. Weintrob, J.D. Altman, D.L. Sodora, M.B. Feinberg, G. Silvestri. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. 2005. J. Immunol, 174:2900-2909.

    G. Brandi, GF. Schiavano, N. Zaffaroni, C. De Marco, M. Paiardini, B. Cervasi, M. Magnani. Mechanisms of action and antiproliferative properties of Brassica oleracea juice in human breast cancer cell lines. 2005. J Nutr, 135:1503-1509.

    Paiardini M, Cervasi B, Dunham R, Sumpter B, Radziewicz H, Silvestri G. Cell cycle dysregulation in the immunopathogenesis of AIDS. 2004. Immunol Res, 29:253-268.

    M Paiardini, B. Cervasi, D. Galati, S. Dominici, H. Albrecht, A. Sfacteria, M. Magnani, G. Silvestri, and G. Piedimonte. Early correction of cell cycle perturbation predicts the immunological response to therapy in HIV-infected patients. 2004. AIDS, 18:393-402

    A. Muthukumar, A. Wozniakowski, M.C. Gauduin, M. Paiardini, H.M. McClure, R.P. Johnson, G. Silvestri, D.L. Sodora. A.Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis durino simian immunodeficiency virus-induced disease progression. 2004. Blood, 103:973-979.

    G. Brandi, M. Paiardini, B. Cervasi, C. Fiorucci, P. Filippone, C. De Marco, N. Zaffaroni, and M. Magnani. A new Indole-3-carbinol tetrameric derivative inhibits CDK6 expression and induces G1 cell cycle arrest in both estrogen dependent and estrogen independent breast cancer cell lines. 2003. Cancer Res, 63:4028-4036.

    M. Magnani, E. Balestra, A. Fraternale, S. Aquaro, M. Paiardini, B. Cervasi, A. Casabianca, E. Garaci, C.F. Perno. Drug-loaded red blood cells-mediated clearance of HIV-1 macrophage reservoir by selective inhibition of STAT1 expression. 2003. J Leukoc Biol, 74:764-771.

    G. Silvestri, D.L. Sodora, R.A. Koup, M. Paiardini, S.P. O'Neil, H.M. McClure, S.I. Staprans, M.B. Feinberg. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. 2003. Immunity. 18:441-452.

    D. Galati*, M. Paiardini*, B. Cervasi, H. Albrecht, M. Bocchino, A. Costantini, M. Montroni, M. Magnani, G. Silvestri, and G. Piedimonte. Specific changes in the post-translational regulation of nucleolin in lymphocytes from HIV-infected patients. 2003. J Infect Dis, 188:1483-1491. *Contributed equally

    Galati D, Bocchino M, Paiardini M, Cervasi B, Silvestri G, Piedimonte G. Cell cycle disregulation during HIV infection: Perspectives of a target based therapy. 2002. Current Drug Targets-Immune, Endocrine & Metabolic Disorders, 2:53-61

    L. Galluzzi, M. Paiardini, M.C. Lecomte, M. Magnani. Identification of the main ubiquitination site in human erythroid alpha-spectrin. 2001. FEBS Lett, 489:254-258.

    G. Cannavò, M. Paiardini, D. Galati, B. Cervasi, I. Picerno, M. Montroni, M. Magnani, G. Silvestri, and G. Piedimonte. Abnormal intracellular kinetics of cell-cycle-dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: a novel biological link between immune activation, accelerated T-cell turnover, and high levels of apoptosis. 2001. Blood, 97:1756-1764.

    M. Paiardini, D. Galati, B. Cervasi, G. Cannavò, L. Galluzzi, M. Montroni, D. Guetard, M. Magnani, G. Piedimonte, and G. Silvestri. Exogenous IL-2 administration corrects the cell cycle perturbation of lymphocytes from HIV-infected individuals. 2001. J Virol, 75:10843-10855.

    L. Galluzzi, G. Nicolas, M. Paiardini, M. Magnani, M.C. Lecomte. Identification of ubiquitinated epeats in human erythroid alpha-spectrin. 2000. Eur J Biochem, 267:2812- 2819

    D. Corsi, M. Paiardini, R. Crinelli, A. Bucchini, M. Magnani. Alteration of alpha-spectrin ubiquitination due to age-dependent changes in the erythrocyte membrane. 1999. Eur J Biochem, 261:775-783

    L. Galluzzi, M. Paiardini, M. Magnani, G. Nicolas, M.C. Lecomte, S. Harper, D.W. Speicher. cDNA sequenze of the human erythroid alpha-spectrin: identification of a base deletion in the sequence database. 1999. Blood, 93:2421-2422

    G. Piedimonte, D. Corsi, M. Paiardini, G. Cannavò, R. Ientile, I Piperno, M. Montroni, G. Silvestri, M. Magnani. Unscheduled cyclin B expression and p34cdc2 activation in T lymphocytes from HIV-infected patients. 1999. AIDS, 13:1159-1164

    Book Chapters -

    Vanderford TH, Paiardini M. Distinct cellular targets of SIV infection in natural and non-natural hosts. In: Natural Hosts of SIV: Implication in AIDS. Ansari AA and Silvestri G, ed. Elsevier Press, 235-256, 2014

    Ende Z, Bonkosky M, Paiardini M. HIV without AIDS: The Immunological Secrets of Natural Hosts. In: HIV and AIDS: Updates on Biology, Immunology, Epidemiology and Treatment Strategies. Nancy Dumais, ed. INTECH, 199-228, 2011