Pathology Faculty Member

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  • Contact Information:

    Emory University Hospital - Pathology
    1364 Clifton Rd NE, Suite H180D
    Atlanta GA 30322
    404-712-4178 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Alyssa Krasinskas, MD

    Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Director, Surgical Pathology, Pathology and Laboratory Medicine, Emory University


    Pathology Division(s):
    Anatomic Pathology


    Email Address:
    akrasin@emory.edu


    Education:

    BA   Clark University, Worcester, MA, - 1990

    MD   University of Rochester School of Medicine and Dentistry, - 1994

    Resident   AP/CP Residency, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, - 2001

    Fellow   GI, Liver and Surgical Pathology Fellow, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, - 2002



    Research Interests:

    - Pancreatic cancer
    Molecular pathogenesis Treatment effect


    - Ampullary cancer
    Classification and staging of ampullary tumors Molecular pathogenesis


    - Peritoneal disease
    Mesotheliomas and mucinous adenocarcinomas


    - Liver allograft rejection



    Clinical Focus:

    GI pathology (resections and biopsies)


    Pancreaticobiliary pathology


    Hepatic pathology (including liver transplantation)


    Director of Surgical Pathology


    Director of GI / Liver Pathology Fellowship


    Selected Publications:

    Published and Accepted Research Articles -

    Xue Y, Vanoli A, Balci S, Reid MM, Saka B, Bagci P, Memis B, Choi H, Ohike N, Tajiri T, Muraki T, Quigley B, El-Rayes BF, Shaib W, Kooby D, Sarmiento J, Maithel SK, Knight JH, Goodman M, Krasinskas AM, Adsay V. Non-ampullary-duodenal carcinomas: clinicopathologic analysis of 47 cases and comparison with ampullary and pancreatic adenocarcinomas. Mod Pathol. 2017 Feb;30(2):255-66.


    Krasinskas AM, Oakley GJ, Bagci P, Jang KT, Kuan SF, Reid MD, Erbarut I, Adsay V. "Simple Mucinous Cyst" of the Pancreas: A Clinicopathologic Analysis of 39 Examples of a Diagnostically Challenging Entity Distinct From Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms. Am J Surg Pathol. 2017 Jan;41(1):121-27.


    Zhelnin K, Xue Y, Quigley B, Reid MD, Choi H, Memis B, Adsay V, Krasinskas AM. Nonmucinous Biliary Epithelium Is a Frequent Finding and Is Often the Predominant Epithelial Type in Mucinous Cystic Neoplasms of the Pancreas and Liver. Am J Surg Pathol. 2017 Jan;41(1):116-20.


    Adsay V, Mino-Kenudson M, Furukawa T, Basturk O, Zamboni G, Marchegiani G, Bassi C, Salvia R, Malleo G, Paiella S, Wolfgang CL, Matthaei H, Offerhaus GJ, Adham M, Bruno MJ, Reid MD, Krasinskas A, Klöppel G, Ohike N, Tajiri T, Jang KT, Roa JC, Allen P, Fernández-Del Castillo C, Jang JY, Klimstra DS, Hruban RH; Members of the Verona Consensus Meeting, 2013. Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract: Recommendations of Verona Consensus Meeting. Ann Surg. 2016;263(1):162-77.


    Muraki T, Reid MD, Basturk O, Jang KT, Bedolla G, Bagci P, Mittal P, Memis B, Katabi N, Bandyopadhyay S, Sarmiento JM, Krasinskas A, Klimstra DS, Adsay V. Undifferentiated Carcinoma With Osteoclastic Giant Cells of the Pancreas: Clinicopathologic Analysis of 38 Cases Highlights a More Protracted Clinical Course Than Currently Appreciated. Am J Surg Pathol. 2016 Sep;40(9):1203-16.


    Saka B, Balci S, Basturk O, Bagci P, Postlewait LM, Maithel S, Knight J, El-Rayes B, Kooby D, Sarmiento J, Muraki T, Oliva I, Bandyopadhyay S, Akkas G, Goodman M, Reid MD, Krasinskas A, Everett R, Adsay V. Pancreatic Ductal Adenocarcinoma is Spread to the Peripancreatic Soft Tissue in the Majority of Resected Cases, Rendering the AJCC T-Stage Protocol (7th Edition) Inapplicable and Insignificant: A Size-Based Staging System (pT1: ¿2, pT2: >2-¿4, pT3: >4 cm) is More Valid and Clinically Relevant. Ann Surg Oncol. 2016 Jun;23(6):2010-8.


    Halenda KM, Kudchadkar RR, Lawson DH, Kies DD, Zhelnin KE, Krasinskas AM, Grossniklaus HE. Reduction of Nodular Growth Pattern of Metastatic Uveal Melanoma after Radioembolization of Hepatic Metastases. Ocul Oncol Pathol. 2016 Apr;2(3):160-5.


    Singhi AD, Krasinskas AM, Choudry HA, Bartlett DL, Pingpank JF, Zeh HJ, Luvison A, Fuhrer K, Bahary N, Seethala RR, Dacic S. The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma. Mod Pathol. 2016 Jan;29(1):14-24.


    Krasinskas AM, Borczuk AC, Hartman DJ, Chabot JA, Taub RN, Mogal A, Pingpank J, Bartlett D, Dacic S. Prognostic significance of morphological growth patterns and mitotic index of epithelioid malignant peritoneal mesothelioma. Histopathology. 2016 Apr;68(5):729-37.


    Gonzalez RS, Bagci P, Basturk O, Reid MD, Balci S, Knight JH, Kong SY, Memis B, Jang KT, Ohike N, Tajiri T, Bandyopadhyay S, Krasinskas AM, Kim GE, Cheng JD, Adsay NV. Intrapancreatic distal common bile duct carcinoma: Analysis, staging considerations, and comparison with pancreatic ductal and ampullary adenocarcinomas. Mod Pathol. 2016 Nov;29(11):1358-69. doi: 10.1038/modpathol.2016.125.


    Reid MD, Balci S, Ohike N, Xue Y, Kim GE, Tajiri T, Memis B, Coban I, Dolgun A, Krasinskas AM, Basturk O, Kooby DA, Sarmiento JM, Maithel SK, El-Rayes BF, Adsay V. Ampullary carcinoma is often of mixed or hybrid histologic type: an analysis of reproducibility and clinical relevance of classification as pancreatobiliary versus intestinal in 232 cases. Mod Pathol. 2016 Dec;29(12):1575-85


    Jin R, Krasinskas A, Le NA, Konomi JV, Holzberg J, Romero R, Vos MB. Association between plasminogen activator inhibitor-1 and severity of liver injury and cardiovascular risk in children with non-alcoholic fatty liver disease. Pediatr Obes. 2016 Oct 20. doi: 10.1111/ijpo.12183. [Epub ahead of print] PMID: 27764892


    Reid MD, Basturk O, Shaib WL, Xue Y, Balci S, Choi HJ, Akkas G, Memis B, Robinson BS, El-Rayes BF, Staley CA, Staley CA, Winer JH, Russell MC, Knight JH, Goodman M, Krasinskas AM, Adsay V. Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. Mod Pathol. 2016 Oct;29(10):1243-53.


    Basturk O, Yang Z, Tang LH, Hruban RH, Adsay V, McCall CM, Krasinskas AM, Jang KT, Frankel WL, Balci S, Sigel C, Klimstra DS. The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms. Am J Surg Pathol. 2015 May;39(5):683-90.


    Zutter MM, Bloom KJ, Cheng L, Hagemann IS, Kaufman JH, Krasinskas AM, Lazar AJ, Leonard DG, Lindeman NI, Moyer AM, Nikiforova MN, Nowak JA, Pfeifer JD, Sepulveda AR, Willis JE, Yohe SL. The Cancer Genomics Resource List 2014. Arch Pathol Lab Med. 2014 Dec 1. 2015 Aug;139(8):989-1008.


    Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting. A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas. Am J Surg Pathol. 2015 Dec;39(12):1730-41.


    Reid MD, Choi HJ, Memis B, Krasinskas AM, Jang KT, Akkas G, Maithel SK, Sarmiento JM, Kooby DA, Basturk O, Adsay V. Serous Neoplasms of the Pancreas: A Clinicopathologic Analysis of 193 Cases and Literature Review With New Insights on Macrocystic and Solid Variants and Critical Reappraisal of So-called "Serous Cystadenocarcinoma". Am J Surg Pathol. 2015 Dec;39(12):1597-610.


    Basturk O, Saka B, Balci S, Postlewait LM, Knight J, Goodman M, Kooby D, Sarmiento JM, El-Rayes B, Choi H, Bagci P, Krasinskas A, Quigley B, Reid MD, Akkas G, Maithel SK, Adsay V. Substaging of Lymph Node Status in Resected Pancreatic Ductal Adenocarcinoma Has Strong Prognostic Correlations: Proposal for a Revised N Classification for TNM Staging. Ann Surg Oncol. 2015;22 Suppl 3:S1187-95.


    Balci S, Basturk O, Saka B, Bagci P, Postlewait LM, Tajiri T, Jang KT, Ohike N, Kim GE, Krasinskas A, Choi H, Sarmiento JM, Kooby DA, El-Rayes BF, Knight JH, Goodman M, Akkas G, Reid MD, Maithel SK, Adsay V. Substaging Nodal Status in Ampullary Carcinomas has Significant Prognostic Value: Proposed Revised Staging Based on an Analysis of 313 Well-Characterized Cases. Ann Surg Oncol. 2015 Dec;22(13):4392-401.


    Boone BA, Sabbaghian S, Zenati M, Marsh JW, Moser AJ, Zureikat AH, Singhi AD, Zeh HJ 3rd, Krasinskas AM. Loss of SMAD4 staining in pre-operative cell blocks is associated with distant metastases following pancreaticoduodenectomy with venous resection for pancreatic cancer. J Surg Oncol. 2014 Aug;110(2):171-5.


    Navina S, McGrath K, Chennat J, Singh V, Pal T, Zeh H, Krasinskas AM. Adequacy assessment of endoscopic ultrasound-guided-fine needle aspirations of pancreatic masses for theranostic studies: Optimization of current practices is warranted. Arch Pathol Lab Med. 2014 Jul;138(7):923-8.


    Hartman DJ, Krasinskas AM, Uttam S, Staton K, Bista R, Rizvi S, Slivka A, Brand R, Liu Y. Assessment of nuclear nanomorphology marker to improve the detection of malignancy from bile duct biopsy specimens. Am J Clin Pathol. 2014 Jun;141(6):884-91.


    Krasinskas AM, Chiosea S, Pal T, Dacic S. KRAS Mutational Analysis and Immunohistochemical Studies Can Help Distinguish Pancreatic Metastases from Primary Lung Adenocarcinomas. Mod Pathol. 2014;27(2):262-70.


    Basturk O, Tang L, Hruban RH, Adsay V, Yang Z, Krasinskas AM, Vakiani E, La Rosa S, Jang KT, Frankel WL, Liu X, Zhang L, Giordano TJ, Bellizzi AM, Chen JH, Shi C, Allen P, Reidy DL, Wolfgang CL, Saka B, Rezaee N, Deshpande V, Klimstra DS. Poorly Differentiated Neuroendocrine Carcinomas of the Pancreas: A Clinicopathologic Analysis of 44 Cases. Am J Surg Pathol. 2014 Apr;38(4):437-47.


    Boone BA, Steve J, Krasinskas AM, Zureikat AH, Lembersky BC, Gibson MK, Stoller RG, Zeh HJ, Bahary N. Outcomes with FOLFIRINOX for borderline resectable and locally unresectable pancreatic cancer. J Surg Oncol. 2013 Sep;108(4):236-41. doi: 10.1002/jso.23392.


    Krasinskas AM, Moser AJ, Saka B, Adsay NV and Chiosea SI. KRAS Mutant Allele Specific Imbalance is Associated with Worse Prognosis in Pancreatic Cancer and Progression to Undifferentiated Carcinoma of the Pancreas. Mod Pathol. 2013 Oct;26(10):3446-54.


    Krasinskas AM, Chiosea S, Pal T, Dacic S. KRAS Mutational Analysis and Immunohistochemical Studies Can Help Distinguish Pancreatic Metastases from Primary Lung Adenocarcinomas. Mod Pathol 2013. Jul 26. doi: 10.1038/modpathol.2013.146. [Epub ahead of print]


    Rajagopalan MS, Heron DE, Wegner RE, Zeh HJ, Bahary N, Krasinskas AM, Lembersky B, Brand R, Moser AJ, Quinn AE, Burton SA. Pathologic response with neoadjuvant chemotherapy and stereotactic body radiotherapy for borderline resectable and locally-advanced pancreatic cancer. Radiat Oncol. 2013 Oct 31;8(1):254.


    Van Buren G 2nd, Ramanathan RK, Krasinskas AM, Smith RP, Abood GJ, Bahary N, Lembersky BC, Shuai Y, Potter DM, Bartlett DL, Zureikat AH, Zeh HJ, James Moser A. Phase II study of induction fixed-dose rate gemcitabine and bevacizumab followed by 30 Gy radiotherapy as preoperative treatment for potentially resectable pancreatic adenocarcinoma. Ann Surg Oncol. 2013 Nov;20(12):3787-93.


    Nikiforova MN, Khalid A, Fasanella KE, McGrath KM, Brand RE, Chennat JS, Slivka A, Zeh HJ, Zureikat AH, Krasinskas AM, Ohori NP, Schoedel KE, Navina S, Mantha GS, Pai RK, Singhi AD. Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: a clinical experience of 618 pancreatic cysts. Mod Pathol. 2013 Nov;26(11):1478-87.


    Whitcomb DC, Larusch J, Krasinskas AM, et al. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Nov 11;44(12):1349-54.


    Hartman DJ, Slivka A, Giusto DA, Krasinskas AM. Tissue Yield and Diagnostic Efficacy of Fluoroscopic and Cholangioscopic Techniques to Assess Indeterminate Biliary Strictures. Clin Gastroenterol Hepatol. 2012 Sep;10(9):1042-6.


    Adsay V, Ohike N, Tajiri T, Kim GE, Krasinskas A, Balci S, Bagci P, Basturk O, Bandyopadhyay S, Jang KT, Kooby DA, Maithel SK, Sarmiento J, Staley CA, Gonzalez RS, Kong SY, Goodman M. Ampullary Region Carcinomas: Definition and Site Specific Classification with Delineation of Four Clinicopathologically and Prognostically Distinct Subsets in an Analysis of 249 Cases. Am J Surg Pathol. 2012 Nov;36(11):1592-1608.


    Owens SR, Walls A, Krasinskas AM, Rund CR. Epstein-Barr Virus Gastritis: Rare or Rarely Sampled? A Case Report. Int J Surg Pathol. 2011 Apr;19(2):196-98.


    Radu O, Nikifirov M, Farkas L, Krasinskas AM. Challenging cases encountered in colorectal cancer screening for Lynch syndrome reveal novel findings: Nucleolar MSH6 staining and impact of prior chemoradiation therapy. Hum Pathol. 2011;42(9):1247-58.


    Raval JS, Zeh HJ, Moser AJ, Lee KK, Sanders MK, Navina S, Kuan SF, Krasinskas AM. Pancreatic lymphoepithelial cysts express CEA and can contain mucous cells: potential pitfalls in the preoperative diagnosis. Mod Pathol. 2010;23(11):1467-76.


    Krasinskas AM, Bartlett D, Cieply K, Dacic S. CDKN2A and MTAP Deletions in Peritoneal Mesotheliomas are Correlated with Loss of p16 Protein Expression and Survival. Mod Pathol. 2010; 23(4):531-8.


    Krasinskas AM, Demetris AJ, Poterucha JJ, Abraham SC. The Prevalence and Natural History of Untreated Isolated Central Perivenulitis in Adult Allograft Livers. Liver Transplantation 2008 May;14(5):625-32.


    Abraham SC, Poterucha JJ, Rosen CB, Demetris AJ and Krasinskas AM. Histologic abnormalities are common in protocol liver allograft biopsies from patients with normal liver function tests. Am J Surg Pathol 2008;32(7):965-73.


    Book Chapters -

    Krasinskas A, Pawlik TM, Mino-Kenudson M and Vauthey JN. Distal bile duct. In: AJCC Cancer Staging Manual. 8th ed. Springer, New York, NY. 2017; 317-326.


    Quigley B and Krasinskas AM. Small Intestine, Appendix, Colorectum, and Anus. In: Essentials of Anatomic Pathology. 4th ed. Springer, New York, NY. 2016; 1907-1944.


    Krasinskas AM. Developmental disorders of the gallbladder, extrahepatic biliary tract and pancreas. In: Goldblum JR and Odze R (eds). Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. 3rd ed. Elsevier, Philadelphia, PA. 2015; 980-994.


    Robinson B and Krasinskas AM. Pathology of premalignant and malignant disease of the esophagus. In: Saba NF and El-Rayes BF (eds). Esophageal cancer Prevention, Diagnosis and Therapy. Springer, New York, NY. 2015; 41-60.


    Krasinskas AM and Goldsmith JD. Immunohistology of the Gastrointestinal Tract. In: Dabbs DA (ed). Diagnostic Immunohistochemistry: Theranostic and Genomic Applications. 4th ed. Elsevier, Philadelphia, PA. 2013; 508-539.