101 Woodruff Circle
Woodruff Memorial Building, Room 7105-B
Atlanta, GA 30322
Attending Physician, Division of Pediatric Hematology/Oncology, Emory University
Director of Apheresis, Children's Healthcare of Atlanta
Assistant Director, Children's Healthcare of Atlanta Transfusion Service, Emory University
BS University of Illinois at Urbana/Champaign, 1995 - 1999
MD The Ohio State University, School of Medicine, 1999 - 2003
Pediatric residency Rush University Medical Center, Chicago IL, 2003 - 2006
Pediatric Hematology/Oncology fellowship Children's National Medical Center, George Washington University School of Medicine, Washington DC, 2006 - 2010
Transfusion Medicine fellowship National Institutes of Health, Bethesda MD, 2008 - 2010
- Red blood cell alloimmunization
Dr. Fasano and his group are interested in understanding the immunologic mechanisms involved in RBC alloimmunization in patients with sickle cell disease (SCD). In collaboration with other investigators, Dr. Fasano has demonstrated a direct role of recipient inflammation on alloimmunization, and continues to investigate immunologic mechanisms involved in alloimmunization. Conceived from murine model data illustrating that transfusion in the presence of pro-inflammatory signals results in higher rates and magnitude of alloimmunization, his group published a large retrospective study in a large human SCD cohort demonstrating that that recipient pro-inflammatory state, most notably acute chest syndrome (ACS) at the time of transfusion, directly impacts RBC alloimmunization. In collaboration with other investigators at Emory, he is currently conducting two follow up translational research studies evaluating immunologic mechanisms involved in RBC alloimmunization overall, and specifically why the frequency is highest during SCD patients during ACS.
Dr. Ross Fasano is an Assistant Professor of Pathology and Laboratory Medicine and Pediatric Hematology/Oncology at Emory University School of Medicine. He also has an adjunct appointment in Adult Hematology and provides comprehensive care to adult patients with sickle cell disease at Grady Memorial Hospital. His clinical expertise is in pediatric transfusion and hematology, with an emphasis on chronic transfusion therapy for children and adults with sickle cell disease. He is trained in Pediatrics, Pediatric Hematology/Oncology, and Blood Banking/Transfusion Medicine. He is the Assistant Director of the transfusion service and Director of Apheresis at Children's Healthcare of Atlanta. During his training and subsequent practice of medicine, he has had extensive clinical experience in managing heavily alloimmunized and iron overloaded patients with sickle cell disease.
NIH Loan Repayment Program for Clinical Research Award Recipient, 2017-2019
NIH Loan Repayment Program for Clinical Research Award Recipient, 2015-2017
2006 American Board of Pediatrics.
2011 American Board of Pathology, Blood Banking/Transfusion Medicine.
2011 American Board of Pediatric Hematology/Oncology
Sagiv E*, Fasano RM*, Luban NL, Josephson CD, Stowell SR, Roback JD, Francis RO, Yee MEM. Glucose-6-Phosphate-Dehydrogenase Deficient Red Blood Cell Units are Associated with Decreased Post-Transfusion Red Blood Cell Survival in Children with Sickle Cell Disease. Am J Hematol. 2018 Jan 27. PMID: 29377292 * Co-first authors
Runco DV, Josephson CD, Raikar SS, Goldsmith K, Lew G, Pauly M, Fasano RM. Hyperleukocytosis in Infant Acute Leukemia: A Role for Manual Exchange Transfusion for Leukoreduction. Transfusion. 2018 Feb 4. PMID: 29399859
Maier CL, Gross PJ, Dean CL, Ip A, McLemore M, El Rassi F, Josephson CD, Fasano RM. Transfusion-Transmitted Malaria Masquerading as Sickle Cell Crisis with Multisystem Organ Failure. Transfusion. 2018 Mar 9. PMID: 29524230
Fish A, Rollins MR, Langley P, King M, Forney C, Josephson CD, Fasano RM. Twiddler's syndrome in an adolescent female with an apheresis port. Transfusion. 2018 Feb;58(2):280-281. PMID: 29411399
Sullivan HC, Gerner-Smidt C, Nooka AK, Arthur CM, Thompson L, Mener A, Patel SR, Yee M, Fasano RM, Josephson CD, Kaufman RM, Roback JD, Lonial S, Stowell SR. Daratumumab (anti-CD38) induces loss of CD38 on red blood cells. Blood. 2017 Jun 1;129(22):3033-3037
Yee MEM, Josephson CD, Winkler AM, Webb J, Luban NL, Leong T, Stowell SR, Fasano RM. Red Blood Cell Minor Antigen Mismatches during Chronic Transfusion Therapy for Sickle Cell Anemia Transfusion. Transfusion. 2017 Nov;57(11):2738-2746. PMID: 28840600
Meier ER, Fasano RM, Levett PR. A systematic review of the literature for severity predictors in children with sickle cell anemia, Blood Cells Mol Dis Feb 2017. PMID: 28185829
Pecker LH, Guerrera MF, Loechelt B, Massaro A, Abraham AA, Fasano RM, Meier ER. Homozygous ¿-thalassemia: Challenges surrounding early identification, treatment, and cure. Pediatr Blood Cancer. 2016 Aug 30. PMID: 27573913
Kaushal M, Byrnes C, Khademian Z, Duncan N, Luban NL, Miller JL, Fasano RM*, Meier ER*. Examination of Reticulocytosis among Chronically Transfused Children with Sickle Cell Anemia. PLoS One. 2016 Apr 26; 11(4):e0153244. PMID: 27116614 (*co-last authors)
Fasano RM, Leong T, Kaushal M, Sagiv E, Luban NL, Meier ER. Effectiveness of red blood cell exchange, partial manual exchange, and simple transfusion concurrently with iron chelation therapy in reducing iron overload in chronically transfused sickle cell anemia patients. Transfusion. 2016 Jul; 56(7):1707-15. PMID: 26997031
Meier ER, Fasano RM, Estrada M, He J, Luban NL, McCarter R. Early reticulocytosis and anemia are associated with abnormal and conditional transcranial Doppler velocities in children with sickle cell anemia. J Pediatr. 2016 Feb; 169:227-231. PMID: 26593107
Tatari-Calderone Z, Gordish-Dressman H, Fasano R, Riggs M, Fortier C, Campbell AD, Charron D, Gordeuk VR, Luban NL, Vukmanovic S, Tamouza R. Protective effect of HLA-DQB1 alleles against alloimunization in patients with sickle cell disease. Hum Immunol. 2016 Jan; 77(1):35-40. PMID: 26476208
Nickel RS, Hendrickson JE, Fasano RM, Meyer EK, Winkler AM, Yee MM, Lane PA, Jones YA, Pashankar FD, New T, Josephson CD, Stowell SR. Impact of red blood cell alloimmunization on sickle cell disease mortality: a case series. Transfusion. 2016 Jan; 56(1):107-14. PMID: 26509333
Fasano RM, Booth GS, Miles M, Du L, Koyama T, Meier ER, Luban NC. Red Blood Cell Alloimmunization is influenced by Recipient Inflammatory State at Time of Transfusion in Patients with Sickle Cell Disease. Br J Haematol. 2015 Jan; 168(2):291-300. PMID: 25256676
Saini S, Speller-Brown B, Wyse E, Meier ER, Carpenter J, Fasano RM, Pearl MS. Unruptured Intracranial Aneurysms in Children With Sickle Cell Disease: Analysis of 18 Aneurysms in 5 Patients. Neurosurgery. 2015 May; 76(5):531-8. PMID: 25710108
Nickel RS, Horan JT, Fasano RM, Meyer E, Josephson CD, Winkler AM, Yee ME, Kean LS, Hendrickson JE. Immunophenotypic parameters and RBC alloimmunization in children with sickle cell disease on chronic transfusion. Am J Hematol. 2015 Dec; 90(12):1135-41. PMID: 26361243
de Vasconcellos JF, Fasano RM, Lee YT, Kaushal M, Byrnes C, Meier ER, Anderson M, Rabel A, Braylan R, Stroncek DF, Miller JL. LIN28A Expression Reduces Sickling of Cultured Human Erythrocytes. PLoS One. 2014 Sep 4; 9(9). PMID: 25188417
Fasano RM, Mamcarz E, Adams S, Donohue Jerussi T, Sugimoto K, Tian X, Flegel WA, Childs RW. Persistence of recipient human leucocyte antigen (HLA) antibodies and production of donor HLA antibodies following reduced intensity allogeneic haematopoietic stem cell transplantation. Br J Haematol. 2014 Aug; 166(3):425-34. PMID: 24750103
Tatari-Calderone Z, Fasano RM, Miles MR, Pinto LA, Luban NL, Vukmanovic S. High multi-cytokine levels are not a predictive marker of alloimmunization in transfused sickle cell disease patients. Cytokine. 2014 Jul; 68(1):59-64. PMID: 24746244
Uchida N, Bonifacino A, Krouse AE, Metzger ME, Csako G, Lee-Stroka A, Fasano RM, Leitman SF, Mattapallil JJ, Hsieh MM, Tisdale JF, Donahue RE. Accelerated lymphocyte reconstitution and long-term recovery after transplantation of lentiviral-transduced rhesus CD34+ cells mobilized by G-CSF and plerixafor. Exp Hematol. 2011 Jul; 39(7):795-805. PMID: 21549175
Fasano RM, Monaco A, Meier ER, Pary P, Lee-Stroka AH, Otridge J, Klein HG, Marincola FM, Kamani NR, Luban NL, Stroncek D, Flegel WA. RH genotyping in a sickle cell disease patient contributing to hematopoetic stem cell transplantation donor selection and management. Blood 2010; 116(15):2836-8. PMID: 20644109
Darbari DS, Castro O, Taylor JG, Fasano R, Rehm J, Gordeuk VR, Minniti CP. Severe vaso-occlusive episodes associated with use of systemic corticosteroids in patients with sickle cell disease. Journ Nat Med Assoc. 2008 Aug; 100: 948-51. PMID: 18717146
Fasano R, Kent P, Valentino L. Superior Vena Cava Thrombus Treated With Low-Dose, Peripherally Administered Recombinant Tissue Plasminogen Activator in a Child: Case Report and Review of the Literature. Jour of Pediatric Hematology/Oncology. 2005 Dec 27(12): 692-695. PMID: 16344681
Hendrickson JE, Fasano RM. Transfusion Support of the Patient with Sickle Cell Disease Undergoing Transplantation. In Meier ER, Abraham A, Fasano RM eds. Sickle Cell Disease and Hematopoietic Stem Cell Transplantation, 1st edition. Springer International, New York, NY; 2017: 111-136.
Fasano RM. T-Activation. In Quillen K ed. Transfusion Medicine in the Hot Seat: A case-based primer. CAP Press, Northfield IL: 2016:31-4
Fasano RM, Hendrickson JE, Luban NL. Alloimmune Hemolytic Disease of the Fetus and Newborn. In Kaushansky K, Lichtman M, Beutler E, Kipps T, Prchal J, Seligsohn U eds. Williams Hematology, 9th edition. McGraw-Hill Professional, New York, NY: 2016:847-62.
Fasano RM. Hyperkalemia in pediatric massive transfusion. In Quillen K ed. Transfusion Medicine in the Hot Seat: A case-based primer. CAP Press, Northfield IL: 2016:80-3.
Fasano RM, Said M, Luban NL. Blood Component Therapy for the Neonate. In RJ Martin, AA Fanaroff eds. Fanaroff & Martin's Neonatal-Perinatal Medicine, 10th edition. St. Louis, MO: 2014:1344-61.
Fasano RM, Luban NL. Transfusion Practices. In De Alarcon P, Wermer E eds. Neonatal Hematology. 2nd edition. Cambridge University Press, Cambridge UK: 2013:303-327.
Fasano RM, Paul WP. Transfusions. In MacDonald MG, Ramasethu J eds. Atlas of Procedures in Neonatology. 5th edition. Lippincott; Philadelphia PA 2012: p 303-15.
Fasano RM, Paul WP, Pisciotto, PT. Complications of Neonatal Transfusion, in M.A. Popovsky Ed. Transfusion Reactions. 4th edition AABB Press, Bethesda, MD: 2012:471-518.
Fasano R, Luban NL. Blood Component Therapy for the Neonate. In RJ Martin, AA Fanaroff eds. Fanaroff & Martin's Neonatal-Perinatal Medicine, 9th edition. St. Louis, MO: 2010:1360-74.
Sickle Cell Disease and Hematopoietic Stem Cell Transplantation. Meier ER, Abraham A, Fasano RM eds, (1st edition). Springer International, New York, NY; 2017.
Fasano RM, Sullivan HC, Bray R, Gebel H, Meyer EK, Winkler AM, Josephson CD, Stowell SR, Duncan A, Roback JD. Genotyping applications for transplantation and transfusion management: The Emory Experience. Arch Pathol Lab Med. 2017 Mar;141(3):329-340. PMID: 28234571
Fasano RM. Hemolytic disease of the fetus and newborn in the molecular era. Semin Fetal Neonatal Med. 2016 Feb; 21(1):28-34. (Review article) PMID: 26589360
Fasano RM, Chou ST. Red Blood Cell Antigen Genotyping for Sickle Cell Disease, Thalassemia, and Other Transfusion Complications. Transfus Med Rev. 2016 May 28. (Review article) PMID: 27345938
Chou ST, Fasano RM. Management of Patients with Sickle Cell Disease Using Transfusion Therapy: Guidelines and Complications. Hematol Oncol Clin North Am. 2016 Jun; 30(3):591-608. (Review article) PMID: 27112998
Fasano RM, Josephson CD. Platelet transfusion goals in oncology patients. Hematology Am Soc Hematol Educ Program. 2015 Dec; 2015(1):462-70. (Review article) PMID: 26637759
Fasano RM, Meier ER, Hulbert ML. Cerebral vasculopathy in children with sickle cell anemia. Blood Cells Mol Dis. 2015 Jan; 54(1):17-25. (Review article) PMID: 25294561
Fasano R, Luban NL. Blood component therapy. Pediatr Clin North Am. 2008 Apr; 55(2): 421-45. (Review) PMID: 18381094