Pathology Faculty Member

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    Experimental Pathology
    505N Whitehead Bldg., 615 Michael St.
    Atlanta, GA 30322
    404 712-8352 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Marla Gearing, PhD

    Neuropathology

    Associate Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Associate Professor, Department of Neurology, Emory University

    Co-Leader, Neuropathology Core, Emory ADRC

    Director, Neuropathology/Histochemistry Core, Emory NINDS Neuroscience Core Facility


    Pathology Division(s):
    Experimental Pathology


    Email Address:
    mgearin@emory.edu


    Education:

    B.S.   Biology, Cornell University, 1977 - 1981

    M.S.   Biology, Emory University, 1982 - 1984

    Ph.D.   Neuroscience, Univ. Wisconsin-Madison, 1984 - 1989



    Research Interests:

    - The overlap among neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease
    There is considerable clinical and neuropathologic overlap among neurodegenerative diseases. Lewy bodies are frequently found in the brains of patients with Alzheimer's disease, and Parkinson's disease patients frequently show Alzheimer's disease at autopsy in addition to their Parkinson's disease. In addition, there in considerable clinical and neuropathologic heterogeneity and overlap in the family of diseases known as "tauopathies". We are interested in the pathogenetic mechanisms underlying these diseases and in how these mechanisms interact with one another.


    - Regional differences in amyloid deposition, processing and association with apolipoprotein E
    While the neocortex displays both neuritic and diffuse plaques in Alzheimer's disease, plaques in the the striatum and cerebellum are predominantly, if not exclusively diffuse, regardless of disease duration. Furthermore, ApoE colocalizes with a subset of plaques in the neocortex and cerebellum, but not in the striatum. Neurofibrillary pathology in the neocortex is typically abundant in throughout much of the neocortex, but the occipital cortex is often relatively, if not entirely, spared. Such regional differences are not only intriguing, but an understanding of the factors underlying these differences could shed light on the pathogenesis of Alzheimer's disease.



    Honors / Awards:

    Honorable Mention, Moore Aware for best paper on clinicopathologic correlation at the annual meeting of the American Association of Neuropathologists, 2004

    Moore Award for the best paper on clinicopathologic correlation at the annual meeting of the American Association of Neuropathologists, 1998

    National Science Foundation Graduate Fellowship, 1983-1986

    Selected Publications:

    Published and Accepted Research Articles -

    Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JS, Kukull WA, Kunkel BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St. George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR, Alzheimer's Disease Genetics Consortium, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer¿s disease loci. Alzheimer¿s Dement 2017;13:727-738.


    Seyfried N, Dammer ED, Swarup V, Nandakumar D, Duong D, Yin L, Deng Q, Nguyen T, Hales CM, Wingo T, Glass J, Gearing M, Thambisetty M, Troncoso JC, Geschwind DH, Lah J, Levey AI. A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease. Cell Systems 2017 Jan 25;4(1):60-72.e4. doi: 10.1016/j.cels.2016.11.006.


    Neltner JH, Abner EL, Jicha GA, Schmitt FA, Patel E, Poon LW, Gearing M, Green RC, Davey A, Johnson MA, Jazwinski SM, Kim S, Davis D, Woodard JL, Kryscio RJ, Van Eldik LJ, Nelson PT. Brain pathologies in extreme old age. Neurobiol Aging 2016;37:1-11.


    Gentry E, Henderson B, Arrant A, Gearing M, Feng Y, Riddle N, Herskowitz J. Rho kinase inhibition as a therapeutic for progressive supranuclear palsy and corticobasal degeneration. J Neurosci 2016;36:1316-1323.


    Buijsen R, Visser J, Kramer P, Severijnen L-A, Gearing M, Berguerand C, Sherman S, Berman R, Willemsen R, Hukema R. Presence of FMRpolyG-positive inclusions in ovarian tissue indicates that non-AUG translation plays a role in FXPOI. Human Reproduction 2016;31:158-168.


    Hu WT, Watts KD, Tailor P, Nguyen TP, Howell JC, Lee RC, Seyfried NT, Gearing M, Hales CM, Levey AI, Lah JJ, Lee EK, ADNI. CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease. Acta Neuropathol Commun 2016;4:14. doi: 10.1186/s40478-016-0277-8.


    Dunn DJ Jr, Gearing M, Park Y, Zhang L, Hanfelt J, Glass JD, Gutman DA. Applicability of digital analysis and imaging technology in neuropathology assessment. Neuropathology 2016;36:270-282.


    Karch CM, Ezerskiy LA, Bertelsen S, Alzheimer's Disease Genetics Consortium (ADGC), Goate AM. Alzheimer¿s disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci. PLOS One 2016 Feb 26;11(2):e0148717. doi: 10.1371/journal.pone.0148717.


    Hales C, Dammer E, Deng Q, Duong D, Gearing M, Troncoso J, Thambisetty M, Lah J, Shulman J, Levey A, Seyfried N. Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's disease progression. Proteomics 2016;16:3042-3053.


    Bernstein AI, Lin Y, Street RC, Lin L, Dai Q, Yu L, Bao H, Gearing M, Lah JJ, Nelson PT, He C, Levey AI, Mullé JG, Duan R, Jin P. 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate tau-induced neurotoxicity. Hum Mol Genet 2016 Jun 15;25(12):2437-2450.


    Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert J-C, Chung J, Naj AC, Kunkle BW, Wang L-S, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Laza AR, Zelenika D, Ramirez A, Foroud TM, Choi S-H, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D, Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eiriksdottir G, Hannequin D, Clarke R, Evans D, Mosley TH Jr, Letenneur L, Brayne C, Maier W, De Jager P, Emilsson V, Dartigues J-F, Hampel H, Kamboh MI, de Bruijn RFAG, Tzourio C, Pastor P, Larson EB, Rotter JI, O'Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St. George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JSK, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L, IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M, Goate AM, Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA. A novel Alzheimer disease locus located near the gene encoding tau protein. Molec Psychiatry 2016;21:108-117.


    Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JSK, Alzheimer's Disease Genetics Consortium. Assessment of the genetic variance of late-onset Alzheimer¿s disease. Neurobiol Aging 2016 May;41:200.e13-20. doi: 10.1016/j.neurobiolaging.2016.02.024.


    Umoh ME, Fournier C, Li Y, Polak M, Shaw L, Landers JE, Hu W, Gearing M, Glass JD. Comparative analysis of C9orf72 and sporadic disease in an ALS clinic population. Neurology 2016;87:1024-1030.


    Dammer EB, Lee AK, Duong D, Gearing M, Lah JJ, Levey AI, Seyfried N. Quantitative phosphoproteomics of Alzheimer's disease reveals crosstalk between kinases and small heat shock proteins. Proteomics 2015.;15:508-519.


    Rangaraju S, Gearing M, Jin L-W, Levey A. Potassium channel Kv1.3 is highly expressed by microglia in Alzheimer's disease. J Alzheimer¿s Dis 2015;44:797-808.


    Zheng C, Geetha T, Gearing M, Ramesh Babu J. Amyloid ß-abrogated TrkA ubiquitination in PC12 cells analogous to Alzheimer's disease. J Neurochem 2015;133:919-925.


    Fournier CN, Gearing M, Upadhyayula SR, Klein M, Glass JD. Head injury does not alter disease progression or neuropathological outcomes in ALS. Neurology 2015;84:1788-1795.


    Mukherjee S, Walter S, Kauwe JS, Saykin AJ, Bennett DA, Larson EB, Crane PK, Glymour MM, Adult Changes in Thought Investigators, Religious Orders Study/Memory and Aging Project Investigators, Alzheimer's Disease Genetics Consortium. Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. Alzheimers Dement 2015;11:1439-1451.


    Ostergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry PRB, Boehme KL, Walter S, Kauwe JS, Gibbons LE, Alzheimer's Disease Genetics Consortium, The GERAD Consortium, EPIC-InterAct Consortium, Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA. Associations between potentially modifiable risk factorsw and Alzheimer disease: A Mendelian randomization study. PLOS Med 2015 June 16;12(6):e1001841. doi: 10.1371/journal.pmed.1001841.


    Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NA, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, Han MR, Beecher S, Geller ET, Kretzschmar HA, Roeber R, Gearing M, Juncos JL, Vonsattel JPG, Van Deerlin VM, Grossman M, Hurtig HI, Gross RG, Arnold SE, Trojanowski JQ, Lee VM, Wenning GK, White CL, Höglinger GU, Müller U, Devlin B, Golbe LI, Crook J, Parisi JE, Boeve BF, Josephs KA, Wszolek ZK, Uitti RJ, Graff-Radford NR, Litvan I, Younkin SG, Wang L-S, Ertekin-Taner N, Rademakers R, Hakonarsen H, Schellenberg GD, Dickson DW. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Commun 2015;6:7247. doi: 10.1038/ncomms8247.


    Rahman-Filipiak A, Woodard JL, Miller LS, Martin P, Davey A, Poon LW, Georgia Centenarian Study. Octogenarian and centenarian performance on the Fuld Object Memory Evaluation. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2015;22;438-451.


    Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith PA, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Lee JH, Schellenberg GD, St George-Hyslop P, Mayeux R, Rogaeva E, the Alzheimer Disease Genetics Consortium. Association of long runs of homozygosity with Alzheimer's disease among African American individuals. JAMA Neurol 2015;72:1313-1323.


    Wang L-S, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Gonzalez Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin C-F, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JSK, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, NIA-LOAD Family Study, Alzheimer's Disease Genetics Consortium. Rarity of the Alzheimer's disease-protective APP A673T variant in the United States. JAMA Neurology 2015;72:209-216.


    Richardson JR, Roy A, Shalat SL, von Stein RT, Hossain MM, Buckley B, Gearing M, Levey AI, German DC. Elevated serum pesticide levels and risk for Alzheimer's disease. JAMA Neurol 2014;71:284-290.


    Allen M, Kachadoorian M, Quicksall Z, Zou F, Chai HS, Younkin C, Crook JE, Pankratz VS, Carrasquillo MM, Krishnan S, Nguyen T, Ma L, Malphrus K, Lincoln S, Bisceglio G, Kolbert CP, Jen J, Mukherjee S, Kauwe JK, Crane PK, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Alzheimer's Disease Genetics Consortium, Parisi JE, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Association of MAPT haplotypes with Alzheimer¿s disease risk and MAPT brain gene expression levels. Alzheimer¿s Research and Therapy 2014;6:39


    Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ. U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21. Mol Neurodegener 2014 Apr 28;9:15. doi: 10.1186/1750-1326-9-15.


    Spears W, Furgerson M, Sweetnam MJ, Evans P, Gearing M, Fechheimer M, Furukawa R. Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain. BMC Neuroscience 2014;15:74. doi: 10.1186/1471-2202-15-74.


    Wu Z, Guo Z, Gearing M, Chen G. Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer's disease model. Nat Commun 2014 June 13;5:4159. doi: 10.1038/ncomms5159


    Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang W-X, Wilfred BR, Wang L-S, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire KR, Monsell SE, ADGC, Schellenberg GD, Fardo DW. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol 2014;127:825-843.


    Hales CM, Dammer EB, Diner I, Yi H, Seyfried NT, Gearing M, Glass JD, Montine TJ, Levey AI, Lah JJ. Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease. Brain Pathol 2014;24:344-351.


    Wu Z, Guo Z, Gearing M, Chen G. Corrigendum: Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer's model. Nature Commun 2014 Sept 12;5:4810. doi: 10.1038/ncomms5810


    Göttle M, Prudente C, Fu R, Pang H, Sutcliffe D, Cooper D, Veledar E, Gearing M, Glass J, Visser J, Jinnah HA. Loss of neurotransmitter phenotype among dopamine neurons in Lesch-Nyhan disease. Ann Neurol 2014;76:95-107.


    Hales CM, Neill SG, Gearing M, Cooper DS, Glass JD, Lah JJ. Late stage CTE pathology in a soccer player with dementia. Neurology 2014;83:2307-2309.


    Diner I, Hales CM, Bishof I, Rabenold L, Duong DM, Yi H, Laur O, Gearing M, Troncoso J, Thambisetty M, Lah JJ, Levey AI, Seyfried NT. Aggregation properties of the small nuclear ribonucleoprotein U1-70 in Alzheimer's disease. J Biol Chem 2014;289:35296-35313.


    Crary J, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Arnold SE, Attems J, Beach T, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jicha GA, Jellinger K, JIcha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee AC, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL 3rd, Wisniewski T, Woltjer RL, Yamada M, Nelson PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol 2014;128:755-766.


    Tadesse T, Gearing M, Senitzer D, Saxe D, Brat D, Bray R, Gebel H, Hill C, Boulis N, Riley J, Feldman E, Johe K, Hazel T, Polak M, Bordeau J, Federici T, Glass J. Analysis of graft survival in a trial of stem cell transplant in ALS. Ann Clin Transl Neurol 2014;1:900-908.


    Haslam A, Johnson MA, Hausman DB, Cress ME, Houston DK, Davey A, Poon LW, Georgia Centenarian Study. Vitamin D status is associated with grip strength in centenarians. J Nutr Gerontol Geriatr 2014;33:35-46.


    Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, Bellenguez C, Brown K, Medway C, Hddick PC, van der Brug MP, Bhangale T, Ortmann W, Behrens T, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Haines JL, Turton J, Braae A, Barber I, Fagan AM, Holtzman DM, Morris JC, 3C Study Group, the EADI Consortium, The Alzheimer's Disease Genetic Consortium (ADGC), Alzheimer¿s Disease Neuroimaging Initiative (ADNI), the GERAD Consortium, Williams J, Kauwe JS, Amouyel P, Morgan K, Singleton A, Jardy J, Goate AM, Cruchaga C. Missense variant in TREML2 protects against Alzheimer¿s disease. Neurobiol Aging 2014;35:1510.e19-26.


    Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, Frosch MP, International Collaboration for Frontotemporal Dementia, Trojanowski JQ, Lee VMY, Van Deerlin V, Chen-Plotkin AS. TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathologica 2014;127:407-418.


    Naj AC, Jun G, Reitz C, Kunkle BW, Perry WR, Park YS, Beecham GW, Rajbhandary R, Hamilton-Nelson KL, Wang L-S, Kauwe JSK, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Nowotny P, Kramer PL, Alzheimer's Disease Genetics Consortium, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St. George-Hyslop P, Buxbaum JD, Evans D, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux R, Farrer LA, Schellenberg GD, Pericak-Vance MA. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: A genome-wide association study. JAMA Neurol 2014;71:1394-1404.


    Deng Q, Holler C, Taylor G, Hudson K, Watkins W, Gearing M, Ito D, Murray M, Dickson D, Seyfried N, Kukar T. FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm following DNA damage. J Neurosci 2014;34:7802-7813.


    Pranski EL, Dalal NV, Van Sanford CD, Herskowitz JH, Gearing M, Lazo C, Miller GW, Lah JJ, Levey AI, Betarbet RS. RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-¿B signaling in dopaminergic cells. Neurobiol Dis 2013;54:264-279.


    Miyashita A, Koike A, Jun G, Wang L-S, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim J-W, Ki C-S, Won H-H, Na DL, Seo SW, Mook-Jung I, Alzheimer Disease Genetics Consortium, St. George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nichida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One 2013;8:e58518. doi: 10.1371/journal.pone.0058618.


    Pranski E, Van Sanford CD, Dalal N, Orr AL, Karmali D, Cooper DS, Gearing M, Lah JJ, Levey AI, Betarbet R. NF-¿B activity is inversely correlated to RNF11 expression in Parkinson's disease. Neuroscience Lett 2013;547:16-20.


    Dammer EB, Duong DM, Diner I, Gearing M, Feng Y, Lah JJ, Levey AI, Seyfried NT. Neuron enriched nuclear proteome isolated from human brain. J Proteome Res 2013;12:3193-3206.


    Johnson EJ, Vishwanathan R, Johnson MA, Hausman DB, Davey A, Scott TM, Green RC, Miller LS, Gearing M, Woodard J, Nelson PT, Chung H-Y, Schalch W, Wittwer J, Poon LW. Relationship between serum and brain carotenoids, ¿-tocopherol, and retinol concentrations and cognitive performance in the oldest old from the Georgia Centenarian Study. J Aging Res 2013:951786. doi: 10.1155/2013/951786.


    Hales CM, Rees H, Seyfried NT, Dammer EB, Duong DM, Gearing M, Montine TJ, Troncoso JC, Thambisetty M, Levey AI, Lah JJ, Wingo TS. Abnormal gephryrin immunoreactivity associated with Alzheimer disease pathologic changes. J Neuropathol Exp Neurol 2013;72:1009-1015.


    Bai B, Hales CM, Chen P-C, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proc Natl Acad Sci USA 2013;110:16562-16567.


    Holton P, Ryten M, Nalls M, Trabzuni D, Weale ME, Hernandez D, Crehan H, Gibbs JR, Mayeux R, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, the Alzheimer's Disease Genetics Consortium, Ramirez-Restrepo M, Engel A, Myers AJ, Corneveaux JJ, Huentelman MJ, Dillman A, Cookson MR, Reiman EM, Singleton A, Hardy J, Guerreiro R. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk loci. Ann Hum Genet 2013;77:85-105.


    Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers RS, Conrad C, Haines JL, Pericak-Vance MA, Fallin MD, Foroud T, Farrer LA, Schellenberg GD, St. George-Hyslop PS, Mayeux R, Alzheimer's Disease Genetics Consortium (ADGC). Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP). Transl Psychiatry May 2013;14;3:e256. doi: 10.1038/tp.2013.13.


    Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang L-S, Valladares O, Lin C-F, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RCP, Griffith P, Obisesan TO, Manley JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R, Alzheimer Disease Genetics Consortium. Variants in the ATP-Binding Cassette Transporter (ABCA7), apolipoprotein E ¿4 and the risk of late-onset Alzheimer disease in African-Americans. JAMA 2013;309:1483-1492.


    Ridge PG, Mukherjee S, Crane PK, Kauwe JSK, Alzheimer's Disease Genetics Consortium. Alzheimer¿s disease: Analyzing the missing heritability. PLoS One 2013 Nov 7;8(11):e79771. doi: 10.1371.


    Stutzbach LD, Xie SX, Naj AC, Albin R, Gilman S, PSP Genetics Study Group, Lee VM-Y, Trojanowski JQ, Devlin B, Schellenberg GD. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. Acta Neuropathol Commun 2013;1:31-13.


    Cruchaga C, Kauwe JSK, Harari O, Jin SC, Cai Y, Karch CM, Benitez B, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee V M-Y, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC, the GERAD Consortium, Alzheimer's Disease Neuroimaging Initiative (ADNI), the Alzheimer Disease Genetic Consortium (ADGC), Goate AM. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer¿s disease. Neuron 2013;78:256-268.


    Cho J, Martin P, Poon LW for the Georgia Centenarian Study. Age group differences in positive and negative affect among oldest-old adults: Findings from the Georgia Centenarian Study. Int'l Aging Hum Devel 2013;77:261-288.


    Xu Z, Poidevin M, Li X, Li Y, Shu L, Nelson DL, Li H, Hales CM, Gearing M, Wingo TS, Jin P. Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration. Proc Natl Acad Aci USA 2013;110:7778-7783.


    Brotherton TE, Li Y, Cooper D, Gearing M, Julien J-P, Rothstein JD, Boylan K, Glass JD. Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS. Proc Natl Acad Sci USA 2012;109:5505-5510.


    Hamilton G, Killick R, The Genetic and Environmental Risk for Alzheimer's Disease (GERAD1) Consortium, the Translational Genomics Research Institute (TGen) Consortium, Lambert J-C, Amouyel P, the European Alzheimer Disease Initiative (EADI), Carrasquillo MM, Pankratz VS, Graff-Radford NR, Dickson DW, Petersen RC, Younkin SG, Powell JF, Wade-Martins R. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiol Aging 2012;33:1848.e1-1848.e13.


    Donovan LE, Higginbotham L, Dammer EB, Gearing M, Rees HD, Xia Q, Duong DM, Seyfried NT, Lah JJ, Levey AI. Analysis of a membrane enriched proteome from post-mortem human brain tissue in Alzheimer's disease. Proteomics Clin Appl 2012;6:201-211.


    Seyfried NT, Gozal YM, Donovan LE, Herskowitz JH, Dammer EB, Xia Q, Ku L, Chang J, Duong DM, Rees HD, Cooper DS, Glass JD, Gearing M, Tansey MG, Lah JJ, Feng Y, Levey A, Peng J. Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards. J Proteome Res 2012;11:2721-2738.


    Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ, Levey AI, Betarbet RS. Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain. Neurosci Lett 2012;520:104-109.


    Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA; Alzheimer's Disease Genetics Consortium, Ross OA, Rademakers R, Schellenberg GD, Miller BL, Mandelkow E, Geschwind DH. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet 2012;21:3500-3512.


    Shaw K, Gearing M, Davey A, Burgess M, Poon LW, Martin P, Green RC. Successful recruitment of centenarians for post-mortem brain donation: Results from the Georgia Centenarian Study. J Biosci Med 2012;2:1-6.


    Hatcher-Martin JM, Gearing M, Steenland K, Levey AI, Miller GW, Pennell KD. Association between polychlorinated biphenyls and Parkinson's disease neuropathology. Neurotoxicology 2012;33:1298-1304.


    Herskowitz JH, Gozal YM, Duong DM, Dammer EB, Gearing M, Ye K, Lah JJ, Peng J, Levey AI, Seyfried NT. Asparaginyl endopeptidase cleaves TDP-43 in brain. Proteomics 2012;12:2455-2463.


    De Jesús-Cortés H, Nogueras-Ortiz CJ, Gearing M, Arnold SE, Vega IE. Amphiphysin-1 protein level changes associated to tau-mediated neurodegeneration. NeuroReport 2012;23:942-946.


    Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, the Alzheimer's Disease Genetics Consortium, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Conwell D, Coté GA, Cotton PB, DiSario J, Farrer LA, Forsmark CE, Johnstone M., Gardner TB, Gelrud A, Greenhalf W, Haines JL, Hartman DJ, Hawes RA, Lawrence C, Lewis M, Mayerle J, Mayeux, R, Melhem NM, Money ME, Muniraj T, Papachristou GI, Pericak-Vance MA, Romagnuolo J, Schellenberg GD, Sherman S, Simon P, Singh VP, Slivka A, Stolz D, Sutton R, Weiss FU, Wilcox CM, Zarnescu NO, Wisniewski SR, O¿Connell MR, Kienholz ML, Roeder K, Barmada MM, Yadav D, Devlin V. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Natur Gen 2012;44:1349-1354.


    Zou F, Chai HS, Younkin CS, Allen M, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus Kg, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Kouri N, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Alzheimer's Disease Genetics Consortium, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Brain expression Genome-Wide Association Study (eGWAS) identifies human disease-associated variants. PLoS Genetics 2012;8(6):e1002707.


    Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Alzheimer's Disease Genetics Consortium, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Novel late-onset Alzheimer¿s disease loci variants associate with brain gene expression. Neurology 2012;79:221-228.


    Jun G, Vardarajan BN, Buros J, Yu C-E, Hawk MV, Dombroski BA, Crane PK, Larson EB, Alzheimer's Disease Genetics Consortium, Mayeux R, Haines JL, Lunetta KL, Pericak-Vance MA, Schellenberg GD, Farrer LA. Comprehensive search for Alzheimer¿s disease susceptibility loci in the APOE region. Arch Neurol 2012;69:1270-1279.


    Davey A, Lele U, Elias MF, Dore GA, Siegler IC, Johnson MA, Hausman DB, Tenover JL, Poon LW for the Georgia Centenarian Study. Diabetes mellitus in centenarians. J Am Geriatr Soc 2012;60:468-473.


    Haslam A, Hausman DB, Johnson MA, Davey A, Poon LW, Allen RH, Stabler SP; Georgia Centenarian Study. Prevalence and predictors of anemia in a population-based study of octogenarians and centenarians in Georgia. J Gerontol A Biol Sci Med Sci 2012;67:100-106.


    Cho J, Martin P, Margrett J, MacDonald M, Johnson MA, Poon LW for the Georgia Centenarian Study. Multidimensional predictors of fatigue among octogenarians and centenarians. Gerontology 2012;58:249-257.


    Hensley B, Martin P, MacDonald M, Siegler IC, Poon LW for the Georgia Centenarian Study. Life events and personality predicting loneliness among centenarians: Findings from the Georgia Centenarian Study. J Psychol 2012;146:173-188.


    Poon LW, Woodard JL, Miller LS, Green R, Gearing M, Davey A, Arnold J, Martin P, Siegler IC, Nahapetyan L, Kim YS, Markesbery W. Understanding dementia prevalence among centenarians. J Gerontol Biol Sci 2012;67A:358-365.


    Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mackenzie IRA, Perry RH, Skullerud K, Yokoo H, Cairns NJ. Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in Neuronal Intermediate Filament Inclusion Disease (NIFID). J Neural Trans 2011;118:1651-1657.


    Gozal YM, Seyfried NT, Gearing M, Glass JD, Heilman CJ, Wuu J, Duong DM, Cheng D, Xia Q, Rees HD, Fritz JJ, Cooper DS, Peng J, Levey AI, Lah JJ. Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration. Mol Neurodegener 2011;6:82.


    Page T, Gitcho MA, Mosaheb S, Carter D, Chakraverty S, Perry RH, Bigio EF, Gearing M, Ferrer I, Goate AM, Cairns NJ, Thorpe JR. FUS immunogold labelling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy. J Molec Neurosci 2011;45:409-421.


    Höglinger GU, Melhem NM, Dickson DW, Sleiman PMA, Wang L-S, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, Hurtig HI, Gross RG, Maetzler W, Goldwurm S, Tolosa E, Borroni B, Pastor P, PSP Genetics Study Group, Cantwell LB, Han MR, Dillman A, van der Brug MP, Gibbs JR, Cookson MR, Gernandez DG, Singleton AB, Farrer MJ, Yu C-E, Golbe LI, Revesz T, Hardy J, Lees AJ, Devlin B, Hakonarson H, Müller U, Schellenberg GD. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat Genet 2011;43:699-707.


    Hausman DB, Johnson MA, Davey A, Woodard JL, Poon LW, Allen RH, Stabler SP for the Georgia Centenarian Study. The oldest old: Red blood cell and plasma folate in African American and white octogenarians and centenarians in Georgia. J Nutr Health Aging 2011;15:744-750.


    Herskowitz JH, Seyfried NT, Gearing M, Kahn RA, Peng J, Levey AI, Lah JJ. Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-ß production. J Biol Chem 2011;286:6117-6127.


    Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mackenzie IR, Perry RH, Skullerud K, Yokoo H, Cairns NJ. The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease. Acta Neuropathol 201;121:219-228.


    Dammer EB, Na CH, Xu P, Seyfried NT, Duong DM, Cheng D, Gearing M, Rees H, Lah JJ, Levey AI, Rush J and Peng J. Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease. J Biol Chem 2011;286:10457-10465.


    Chen-Plotkin AS, Markinez-Lage M, Sleiman PMA, Hu W, Greene R, McCarty E, Bing S, Grossman M, Schellenberg G, Hatanpaa KJ, Weiner MF, White CL III, Brooks W, Halliday GM, Kril JJ, Gearing M, Beach TG, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Pickering-Brown SM, Snowden J, van Swieten JC, Seelaar H, Murrell JR, Ghetti B, Spina S, Grafman J, Kaye JA, Woltjer RL, Mesulam M, Lladó A, Miller BL, Alzualde A, Moreno F, Rohrer JD, Mackenzie IRA, Feldman HH, Hamilton RL, Cruts M, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bird TD, Cairns NJ, Goate A, Frosch MP, Riederer PF, Bogdanovic N, Lee VMY, Trojanowski JQ, Van Deerlin VM. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Arch Neurol 2011;68:488-497.


    Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, Santacruz KS, Sonnen JA, Poon LW, Gearing M, Green RC, Woodard JL, Van Eldik LJ, Kryscio RJ. Hippocampal sclerosis in advanced age: Clinical and pathological features. Brain 2011;134:1506-1518.


    Gozal YM, Dammer EB, Duong DM, Cheng D, Gearing M, Rees HD, Peng J, Lah JJ, Levey AI. Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: Application of laser capture technology. Frontiers in Neurology 2011;2:24.


    Richardson JR, Roy A, Shalat SL, Buckley B, Winnik B, Gearing M, Levey AI, Factor SA, O'Suilleabhain P, German DC. ß-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease. NeuroToxicology 2011;32:640-645


    Chang MC, DeCaro JJ, Zheng M, Gearing M, Shubeck L, Sherman SL, Welt CK. Ovarian histopathologic and ubiquitin-immunophenotypic features in Fragile-X-associated primary ovarian insufficiency: A study of five cases and selected controls. Histopathology 2011;59:1018-1023.


    Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, Irier H, Upadhyay AK, Gearing M, Levey AI, Vasanthakumar A, Godley LA, Chang Q, Cheng X, He C, Jin P. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci 2011;14:1607-1616.


    Naj AC, Jun G, Beecham GW, Wang L-S, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JSK, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin L-W, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantrell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TA, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011;43:436-443.


    MacDonald M, Aneja A, Martin P, Margrett J, Poon LW for the Georgia Centenarian Study. Distal and proximal resource influences on economic dependency among the oldest old. Gerontology 2010;56:100-105.


    Randall GK, Martin P, McDonald M, Poon LW for the Georgia Centenarian Study. Social resources and longevity: Findings from the Georgia Centenarian Study. Gerontology 2010;56:106-111.


    Johnson MA, Hausman DB, Davey A, Poon LW, Allen RH, Stabler SP for the Georgia Centenarian Study. Vitamin B12 deficiency in African American and white octogenarians and centenarians in Georgia. J Nutr Health Aging 2010;14:339-345.


    Armstrong RA, Ellis W, Hamilton RL, Mackenzie IRA, Hedreen J, Gearing M, Montine T, Vonsattel J-P, Head E, Lieberman AP, Cairns NJ. Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: A quantitative study of 94 cases using principal components analysis. J Neural Trans 2010;117:227-239.


    Herskowitz JH, Seyfried NT, Duong DM, Xia Q, Rees HD, Gearing M, Peng J, Lah JJ, Levey AI. Phophoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration. J Proteome Res 2010;9:6368-6379.


    Miller LS, Mitchell MB, Woodard JL, Davey A, Martin P, Poon LW, Jazwinski SM, Green RC, Gearing M, Markesbery WR, Johnson MA, Tenover JS, Rodgers WL, Hausman DB, Arnold J, Siegler IC. Cognitive performance in centenarians and the oldest old: Norms from the Georgia Centenarian Study. Neuropsychol Dev Cogn B. Aging Neuropsych Cogn 2010;17:575-590.


    Jazwinski SM, Kim S, Dai J, Li L, Bi X, Jiang JC, Arnold J, Batzer MA, Walker JA, Welsh DA, Lefante CM, Volaufova J, Myers L, Su LJ, Hausman DB, Miceli MV, Ravussin E, Poon LW, Cherry KE, Welsch MA; Georgia Centenarian Study and the Louisiana Healthy Aging Study. HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging. Aging Cell 2010;9:698-708.


    Rosen RF, Ciliax BJ, Wingo TS, Gearing M, Dooyema J, Wingo T, Lah JJ, Ghiso JA, LeVine H, III, Walker LC. Deficient high-affinity binding of Pittsburgh Compound B in a case of Alzheimer's disease. Acta Neuropathol 2010;119:221-233.


    Van Deerlin VM, Sleiman PMA, Martinez-Lage M, Chen-Plotkin A, Wang L-S, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DMA, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, al-Sarraj S, Troakes C, Rosenberg RN, White CL III, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, de Munain AL, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IRA, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JPG, Troncoso JC, Kril JJ, Kwok JBJ, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Caballero Martinez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM-Y. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genet 2010;42:234-239.


    Hensley B, Martin P, MacDonald M, Poon L for the Georgia Centenarian Study. Family history and adaptation among centenarians and octogenarians. Gerontology 2010;56:83-87.


    Bishop AJ, Martin P, MacDonald M, Poon L for the Georgia Centenarian Study. Predicting happiness among centenarians. Gerontology 2010;56:88-92.


    Margrett J, Martin P, Woodard JL, Miller LS, MacDonald M, Baenziger J, Siegler IC, Davey A, Poon L for the Georgia Centenarian Study. Depression among centenarians and the oldest old: Contributions of cognition and personality. Gerontology 2010;56:93-99.


    Jun G, Naj AC, Beecham GW, Wang L-S, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St. George-Hyslop P, Alzheimer's Disease Genetics Consortium, Cantwell L, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer¿s disease risk loci and reveals interactions with APOE genotypes. Arch Neurol 2010;67:1473-1484.


    Hwang H, Zhang J, Chung KA, Leverenz JB, Zabetian CP, Peskind ER, Jankovic J, Su Z, Hancock AM, Pan C, Montine TJ, Pan S, Nutt J, Albin R, Gearing M, Beyer RP, Shi M, Zhang J. Glycoproteomics in neurodegenerative diseases. Mass Spec Rev 2010;29:79-125.


    Yang Q, She H, Gearing M, Colla E, Lee M, Shacka JJ, Mao Z. Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 2009;323:124-127.


    Mastroberardino PG, Hoffman EK, Horowitz MP, Betarbet R, Taylor G, Cheng D, Na HM, Gutekunst C-A, Gearing M, Trojanowski JQ, Anderson M, Chu CT, Peng J, Greenamyre JT. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol Dis 2009;34:417-431.


    Gozal Y, Duong D, Gearing M, Cheng D, Hanfelt J, Funderburk C, Peng J, Lah J, Levey A. Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease. J Proteome Res 2009;8:5069-5079.


    Du Y, Wooten MC, Gearing M, Wooten MW. Age-associated oxidative damage to the p62 promoter: Implications for Alzheimer's disease. Free Radical Biol Med 2009;46:492-501.


    Rosen RF, Farberg AS, Gearing M, Dooyema J, Long PM, Anderson DC, Davis-Turak J, Coppola G, Geschwind DH, Pare J, Duong TQ, Hopkins WD, Preuss TM, Walker LC. Tauopathy with paired helical filaments in an aged chimpanzee. J Comp Neurol 2008;509;259-270.


    Xia Q, Liao L, Cheng D, Duong D, Gearing M, Lah JJ, Levey AI, Peng J. Proteomic identification of novel proteins associated with Lewy bodies. Frontiers in Bioscience 2008;13:3850-3856.


    Liu R, Tian B, Gearing M, Hunter S, Ye K, Mao Z. Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion. Proc Natl Acad Sci USA 2008;105:7570-7575.


    Xia Q, Cheng D, Duong DM, Gearing M, Lah JJ, Levey AI, Peng J. Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry. J Proteome Res 2008;7:2845-2851.


    Shi M, Jin J, Wang Y, Beyer RP, Kitsou E, Albin RL, Gearing M, Pan C, Zhang J. Mortalin: A protein associated with progression of Parkinson's disease. J Neuropathol Exp Neurol 2008;67:117-124.


    Borges K, Gearing M, Rittling S, Sorensen ES, Kotloski R, Denhardt DT, Dingledine R. Characterization of osteopontin expression and function after status epilepticus. Epilepsia 2008;49:1675-1685.


    Betarbet R, Anderson LR, Gearing M, Hodges TR, Fritz JJ, Lah JJ, Levey AI. Fas-associated factor 1 and Parkinson's disease. Neurobiol Dis 200;31:309-315.


    Johnson MA, Davey A, Park S, Hausman DB, Poon LW; Georgia Centenarian Study. Age, race and season predict vitamin D status in African American and white octogenarians and centenarians. J Nutr Health Aging 2008;12:690-695.


    Kitsou E, Pan S, Zhang JP, Shi M, Zabeti A, Dickson DW, Albin R, Gearing M, Kashima DT, Wang Y, Beyer RP, Zhou Y, Pan C, Caudle WM, Zhang J. Identification of proteins in human substantia nigra. Proteomics - Clinical Applications 2008;2:776-782.


    Dai J, Li L, Kim S, Kimball B, Jazwinski SM, Arnold J for the Georgia Centenarian Study. Exact sample size needed to detect dependence in 2 x 2 x 2 tables. Biometrics 2007;63:1245-1252.


    Poon LW, Jazwinski M, Green RC, Woodard JL, Martin P, Rodgers WL, Johnson MA, Hausman D, Arnold J, Davey A, Batzer MA, Markesbery WR, Gearing M, Siegler IC, Reynolds S, Dai J. Methodological Considerations in Studying Centenarians: Lessons Learned From the Georgia Centenarian Studies. Annu Rev Gerontol Geriatr 2007;27:231-264.


    Sager KL, Wuu J, Leurgans SE, Rees HD, Gearing M, Mufson EJ, Levey AI, Lah JJ. Neuronal LR11/SorLA expression is reduced in Mild Cognitive Impairment. Ann Neurol 2007;62:640-427.


    Pan S, Shi M, Jin J, Albin RL, Lieberman A, Gearing M, Lin B, Pan C, Yan X, Kashima DT, Zhang J. Proteomics identification of proteins in human cortex using multi-dimensional separations and MALDI tandem mass spectrometer. Molec Cellular Proteomics 2007;6:1818-1823.


    Anderson LR, Betarbet R, Gearing M, Gulcher J, Hicks AA, Stefánsson K, Lah JJ, Levey AI. PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. J Neuropathol Exp Neurol 2007;66:955-964.


    Hu X, Shi Q, Zhou X, He W, Yi H, Yin X, Gearing M, Levey A, Yan R. Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities. EMBO J 2007;26:2755-2767.


    Procaccio V, Salazar G, Ono S, Styers ML, Gearing M, Davila A, Jimenez R, Juncos J, Gutekunst C-A, Meroni G, Fontanella B, Sontag E, Sontag JM, Faundez V, Wainer BH. A mutation of b-actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. Am J Hum Genet 2006;78:947-960.


    Johnson MA, Davey A, Hausman DB, Park S, and Poon LW for the Georgia Centenarian Study. Dietary differences between centenarians residing in communities and in skilled nursing facilities: the Georgia Centenarian Study. Age 2006;28:333-341.


    Dodson SE, Gearing M, Lippa CF, Montine TJ, Levey AI, Lah JJ. LR11/SorLA expression is reduced in sporadic Alzheimer's disease but not in familial AD. J Neuropathol Exp Neurol 2006;65:866-872.


    Offe K, Dodson SE, Shoemaker JT, Fritz JJ, Gearing M, Levey AI, Lah JJ. The lipoprotein receptor LR11 regulates amyloid b production and amyloid precursor protein traffic in endosomal compartments. J Neurosci 2006;26:1596-1603.


    Choi J, Sullards MC, Olzmann JA, Rees HD, Weintraub ST, Bostwick DE, Gearing M, Levey AI, Chin L-S, Li L. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem 2006;281:10816-10824.


    Momeni P, Cairns NJ, Perry RH, Bigio EH, Gearing M, Singleton AB, Hardy J. Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID). Neurobiol Aging 2006;27:778.e1-778.e6.


    Martin P, da Rosa G, Siegler IC, Davey A, MacDonald M, and Poon LW for the Georgia Centenarian Study. Personality and longevity: findings from the Georgia Centenarian Study. Age 2006;28:343-352.


    Mosaheb S, Thorpe JR, Hashemzadeh-Bonehi L, Bigio EH, Gearing M, Cairns NJ. Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion disease. Acta Neuropathol 2005;110:360-368.


    Salazar G, Love R, Styers ML, Werner E, Peden A, Rodriguez S, Gearing M, Wainer BH, Faundez V. AP3-dependent mechanisms control the targeting of a chloride channel (ClC3) in neuronal and non-neuronal cells. J Biol Chem 2004;279:25430-25439.


    Cairns NJ, Uryu K, Bigio E, Mackenzie IRA, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Arnold SE, Lee VM-Y, Trojanowsky JQ. a-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Acta Neuropathol 2004;108:213-223.


    Scherzer CR, Offe K, Gearing M, Rees HD, Fang G, Heilman CJ, Schaller C, Bujo H, Levey AI, Lah JJ. Loss of ApoE receptor LR11 in Alzheimer's disease. Arch Neurol 2004;61:1200-1205.


    Cairns NJ, Grossman M, Arnold SE, Burn DJ, Jaros E, Perry RH, Duyckaerts C, Stankoff B, Pillon B, Skullerud K, Cruz-Sanchez FF, Bigio EJ, Mackenzie IRA, Gearing M, Juncos JL, Glass JD, Yokoo H, Nakazato Y, Mosaheb S, Thorpe JR, Uryu K, Lee VM-Y, Trojanowski JQ. Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease (NIFID). Neurology 2004;63:1376-1384.


    Choi J, Levey AI, Weintraub ST, Rees HD, Gearing M, Chin L-S, Li L. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimers diseases. J Biol Chem 2004;279:13256-13264.


    Okun MS, DeLong MR, Hanfelt J, Gearing M, Levey A. Testosterone levels in an Alzheimer's-Parkinsons disease registry. Neurology 2004;62:411-413.


    Cairns NJ, Zhukareva V, Uryu K, Zhang B, Bigio E, Mackenzie IRA, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Lee VM-Y, Trojanowski JQ. a-Internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. Am J Pathol 2004;164:2153-2161.


    Liao L, Cheng D, Wang J, Duong DM, Losik TG, Gearing M, Rees HD, Lah JJ, Levey AI, Peng J. Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection. J Biol Chem 2004;279:37061-37068.


    Borges K, Gearing M, McDermott DL, Smith AB, Almonte AG, Wainer BH, Dingledine R. Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Experimental Neurology 2003;182:21-34.


    Gearing M, Juncos JL, Procaccio V, Gutekunst C-A, Marino EM, Gyure KA, Ono S, Santoianni R, Krawiecki NS, Wallace DC, Wainer BH. Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia. Ann Neurol 2002;52:465-476.


    Goldstein FC, Ashley AV, Gearing M, Hanfelt J, Penix L, Freedman L, Levey AI. Apolipoprotein E and age of onset of Alzheimer's disease in African American patients. Neurology 2001;57:1923-1925.


    Brat DJ, Goldthwaite P, Gearing M, Wainer BH, Burger PC. Tau-associated neuropathology in ganglion cell tumors increases with patient age but is unrelated to ApoE genotype. Neuropathol Appl Neurobiol 2001;27:197-205.


    Okun MS, Stover NP, Subramanian T, Gearing M, Wainer BH, Holder CA, Watts RL, Juncos JL, Freeman A, Evatt ML, Schuele SU, Vitek JL, DeLong MR. Complications of gamma knife surgery for Parkinson disease. Arch Neurol 2001;58:1995-2002.


    Mizuno M, Gearing M, Terasawa E. The role of neuropeptide Y in the progesterone-induced luteinizing hormone-releasing hormone surge in vivo in ovariectomized female rhesus monkeys. Endocrinology 2000;141:1772-1779.


    Tsuang D, Larson EB, Bowen J, McCormick W, Teri L, Nochlin D, Leverenz JB, Peskind ER, Lim A, Raskind MA, Thompson ML, Mirra SS, Gearing M, Schellenberg GD, Kukull W. The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based series. Arch Neurol 1999;56:1489-1495.


    Wolf DS, Gearing M, Snowdon DA, Mori H, Markesbery WR, Mirra SS. Progression of regional neuropathology in Alzheimer's disease and normal elderly: Findings from the Nun Study. Alzheimer Dis Assoc Disord 1999;13:226-231.


    Heyman A, Fillenbaum GG, Gearing M, Mirra SS, Welsh-Bohmer KA, Peterson B, Pieper C. Comparison of Lewy body variant of Alzheimer's disease with pure Alzheimers disease. Consortium to Establish a Registry for Alzheimers Disease, part XIX. Neurology 1999;52:1839-1844.


    Mirra SS, Murrell JR, Gearing M, Spillantini MG, Goedert M, Crowther RA, Levey AI, Jones R, Green J, Shoffner JM, Wainer BH, Schmidt ML, Trojanowski JQ, Ghetti B. Tau pathology in a family with dementia and a P301L mutation in tau. J Neuropathol Exp Neurol 1999;58:335-345.


    Gearing M, Lynn M, Mirra SS. Neurofibrillary pathology in Alzheimer's disease with Lewy bodies: Two subgroups. Arch Neurol 1999;56:203-208.


    Berg L, McKeel DW Jr, Miller JP, Storandt M, Rubin EH, Morris JC, Baty J, Coats M, Norton J, Goate AM, Price JL, Gearing M, Mirra SS, Saunders AM. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: Relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch Neurol 1998;55:326-335.


    Heyman A, Fillenbaum G, Welsh-Bohmer K, Gearing M, Mirra SS, Mohs R, Peterson B, Pieper C. Cerebral infarcts in patients with autopsy-proven Alzheimer's disease. CERAD, part XVIII. Neurology 1998;51:159-162.


    Mayeux R, Saunders A, Shea S, Mirra S, Evans D, Roses AD, Hyman BT, Crain B, Tang M-X, Phelps CH, and the Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimers Disease. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimers disease. N Engl J Med 1998;338:506-511.


    Gearing M, Levey AI, Mirra SS. Diffuse plaques in the striatum in Alzheimer's disease (AD): Relationship to the striatal mosaic and selected neuropeptide markers. J Neuropathol Exp Neurol 1997;56:1363-1370.


    Farrer LA, et al, and the ApoE and Alzheimer Disease Meta Analysis Consortium. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. JAMA 1997;278:1349-1356.


    Shao Y, Gearing M, Mirra SS. Astrocyte-apolipoprotein E associations in senile plaques in Alzheimer disease and vascular lesions: A regional immunohistochemical study. J Neuropathol Exp Neurol 1997;56:376-381.


    Ishii K, Tamaoka A, Mizusawa H, Shoji S, Ohtake T, Fraser PE, Takahashi H, Tsuji S, Gearing M, Mizutani T, Yamada S, Kato M, St. George-Hyslop PH, Mirra SS, Mori H. A¿1-40 but not A¿1-42 levels in cortex correlate with apolipoprotein E e4 allele dosage in sporadic Alzheimer's disease. Brain Res 1997;748:250-252.


    Schneider JA, Watts RL, Gearing M, Brewer RP, Mirra SS. Corticobasal degeneration: Neuropathological and clinical heterogeneity. Neurology 1997;48:959-969.


    Gearing M, Tigges J, Mori H, Mirra SS. Changes in the brains of aged orangutans. Neurobiol Aging 1997;18:139-146.


    Welsh-Bohmer KA, Gearing M, Saunders AM, Roses AD, Mirra S. Apolipoprotein E genotypes in a neuropathological series from the Consortium to Establish a Registry for Alzheimer's Disease. Ann Neurol 1997;42:319-325.


    Gearing M, Mori H, Mirra SS. A¿ peptide length and apolipoprotein E (ApoE) genotype in Alzheimer's disease. Ann Neurol 1996;39:395-399.


    Gearing M, Tigges J, Mori H, Mirra SS. A¿40 is a major form of ¿-amyloid in nonhuman primates. Neurobiol Aging 1996;17:903-908.


    Gearing M, Schneider JA, Rebeck GW, Hyman BT, Mirra SS. Alzheimer's disease with and without coexisting Parkinson's disease changes: Apolipoprotein E genotype and neuropathologic correlates. Neurology 1995;45:1985-1990.


    Gearing M, Schneider JA, Robbins RS, Hollister RD, Mori H, Games D, Hyman BT, Mirra SS. Regional variation in the distribution of apolipoprotein E and A¿ in Alzheimer's disease. J Neuropathol Exp Neurol 1995;54:833-841.


    Kim H, Gearing M, Mirra SS. Ubiquitin-positive CA2/3 neurites in hippocampus coexist with cortical Lewy bodies. Neurology 1995;45:1768-1770.


    Schneider JA, Gearing M, Robbins RS, de l'Aune W, Mirra SS. Apolipoprotein E genotype in diverse neurodegenerative disorders. Ann Neurol 1995;38:131-135.


    Gearing M, Mirra SS, Hedreen JC, Sumi SM, Hansen LA, Heyman A. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease. Neurology 1995;45;461-466.


    Davis PC, Gearing M, Gray L, Mirra SS, Morris JC, Edland SD, Lin T, Heyman A. The CERAD experience, Part VIII: Neuroimaging-neuropathology correlates of temporal lobe changes in Alzheimer's disease. Neurology 1995;45:178-179.


    Gearing M, Rebeck GW, Hyman BT, Tigges J, Mirra SS. Neuropathology and apolipoprotein E profile of aged chimpanzees: Implications for Alzheimer's disease. Proc Natl Acad Sci USA 1994;91:9382-9386.


    Poduri A, Gearing M, Rebeck GW, Mirra SS, Tigges J, Hyman BT. Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys. Am J Pathol 1994;144:1183-1187.


    Mirra SS, Gearing M, McKeel DW Jr, Crain BJ, Hughes JP, Van Belle G, Heyman A, participating neuropathologists. Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: A study of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). J Neuropathol Exp Neurol 1994;53:303-315.


    Gearing M, Olson DA, Watts RL, Mirra SS. Progressive supranuclear palsy: Neuropathological and clinical heterogeneity. Neurology 1994;44:1015-1024.


    Gearing M, Wilson RW, Unger ER, Shelton ER, Chan HW, Masters CL, Beyreuther K, Mirra SS. Amyloid precursor protein (APP) in the striatum in Alzheimer's disease: An immunohistochemical study. J Neuropathol Exp Neurol 1993;52;14-21.


    Shoffner JM, Brown MD, Torroni A, Lott MT, Cabell MF, Mirra SS, Beal MF, Yang C-C, Gearing M, Salvo R, Watts RL, Juncos JL, Hansen LA, Crain BJ, Fayad M, Reckord CL, Wallace DC. Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. Genomics 1993;17:171-184.


    Gearing M, Terasawa E. Prostaglandin E2 mediates the stimulatory effect of methoxamine on in vivo luteinizing hormone releasing hormone (LHRH) release in the ovariectomized female rhesus monkey. Brain Res 1991;560:276-281.


    Gearing M, Terasawa E. Suppression of luteinizing hormone release by the alpha1-adrenergic receptor antagonist prazosin in the ovariectomized female rhesus monkey. Am J Primatol 1991;25:23-33.


    Gearing M, Terasawa E. The alpha-1-adrenergic neuronal system is involved in the pulsatile release of luteinizing hormone-releasing hormone in the ovariectomized female rhesus monkey. Neuroendocrinology 1991;53:373-381.


    Terasawa E, Krook C, Hei DL, Gearing M, Schultz NJ, Davis GA. Norepinephrine is a possible neurotransmitter stimulating pulsatile release of luteinizing hormone releasing hormone in the rhesus monkey. Endocrinology 1988;123:1808-1816.


    Gearing M, Terasawa E. Luteinizing hormone releasing hormone (LHRH) neuroterminals mapped using the push-pull perfusion method in the rhesus monkey. Brain Res Bull 1988;21:117-121.


    Bruot BC, Gearing M, Musey PI, Wilson ME, Collins DC. Steroidogenesis by the immature rhesus monkey ovary in vitro. J Endocrinol Invest 1986;9:171-175.


    Book Chapters -

    Gearing M, Mirra SS. Neuropathology of movement disorders: An overview. In: Watts RL, Koller WC, eds. Movement Disorders: Neurologic Principles and Practice. 2nd edition. New York: McGraw-Hill, 2004:143-158.


    Mirra SS, Schneider JA, Gearing M. Neuropathology of movement disorders: An overview. In: Watts RL, Koller WC, eds. Movement Disorders: Neurologic Principles and Practice. New York: McGraw-Hill, 1997:125-134.


    Mirra SS, Gearing M. The neuropathology of Alzheimer's disease and related dementias. In: Morris JC, ed. Handbook of Dementing Illnesses. New York: Marcel Dekker, 1994:189-226.


    Other Publications -

    Reitz C, Mayeux R, for the Alzheimer's Disease Genetics Consortium. TREM2 and neurodegenerative disease. N Engl J Med 2013;369:1564-1565


    Mirra SS, Gearing M, Nash F. The neuropathological assessment of Alzheimer's disease. Neurology 1997;49(Suppl 3):S14-S16.


    Mirra SS, Gearing M. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study [letter]. JAMA 1997;278:113.


    Gearing M, Mirra SS, Hedreen JC, Sumi SM, Hansen LA, Heyman A. AD Neuropathology: Reply. Neurology 1996;46:1186-1187.


    Mirra SS, Gearing M, McKeel DW, Crain BJ, Hughes JP, van Belle G, Heyman A. Consortium to Establish a Registry for Alzheimer's Disease: Reply. J Neuropathol Exp Neurol 1995;54:131.


    Mirra SS, Gearing M, Heyman A. CERAD Guide to the Neuropathological Assessment of Alzheimer's Disease and Other Dementias. Copyright CERAD, 1994.


    Mirra S, Gearing M, Sumi SM, Crain B, Heyman A, CERAD neuropathologists. The neuropathological assessment of Alzheimer's disease and related dementias: The CERAD experience. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski H, Zatta P, eds. Alzheimer's Disease: Advances in Clinical and Basic Research. New York: John Wiley & Sons, Ltd., 1993:207-211. Presented at the 3rd International Conference on Alzheimer's Disease and Related Disorders in Padua, Italy.