Other Appointments/Positions

Professor, Otolaryngology Head & Neck Surgery, Emory University School of Medicine

Professor, Winship Cancer Institute

Pathology Division(s):
Anatomic Pathology
Experimental Pathology

Email Address:
susan.muller@emoryhealthcare.org

Education:

B.A. (Biology)   Rutgers University, NJ, 1974 - 1979

M.S. (Nutrition Science)   Drexel University, Philadelphia, PA, 1981 - 1983

D.M.D.   Medical University of South Carolina School of Dental Medicine, 1985 - 1989

  Post-Doctoral Research Fellow, Microbiology and Immunology Medical Univ. South Carolina, Charleston, 1989 - 1990

  Resident, Oral and Maxillofacial Pathology, Emory University School of Medicine, Atlanta, GA, 1990 - 1993

  Clinical Fellow, Head and Neck Pathology, Presbyterian University Hospital, Univ. of Pittsburgh Medical Center, 1993 - 1994

Research Interests:

- Overview
I collaborate with researchers at Winship Cancer Institute investigating molecular markers of oral cancer, including models of oral cancer metastasis. Another project is looking at predictors of malignant transformation of oral leukoplakia. Other research interests include participation in a chemoprevention trial for patients with oral dysplasias to see if this will impede transformation to oral cancer. Working closely with the Otolaryngologists on faculty, I am involved in the histologic typing of various head and neck tumors, particularly odontogenic and salivary gland tumors and how they relate to clinical outcomes.

Clinical Focus:

I am actively involved in the head and neck pathology service, which receives specimens from the metropolitan Atlanta region and outlying counties. I provide expert consultation in the typing of odontogenic cysts and tumors, salivary gland tumors, and unusual neoplasms of the upper aerodigestive tract.

Honors / Awards:

1989 - Omicron Kappa Upsilon, National Dental Honorary Society.,

Specialty Boards:

1994  American Board of Oral and Maxillofacial Pathology

Selected Publications:

Published and Accepted Research Articles -

Muller, S. Oral manifestations of dermatologic disease: A focus on lichenoid lesions. Head Neck Pathol 5:36-40, 2011.

Durden FL, Müller S, Gaffga CM, Moore CE. Verrucous Carcinoma of the Paranasal Sinuses: A Case Report. ENT J 89(7): E21-23, 2010

Muller S. Oral Melanin Pigmented Lesions: Presentation, Differential Diagnosis, and Treatment. Dermatol Therapies 23: 220-229, 2010

Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Gu TL, Polakiewicz RD, Chen Z(G), Khuri FR, Shin DM, Chen J. RSK2 promotes head and neck cancer cell invasion and tumor metastasis. JCI 120: 1165-1177, 2010

Elrod HA, Fan S, Muller S, Chen GZ, Pan L, Tighiouart M, Shin DM, Khuri FR, Sun SY. Analysis of Death Receptor 5 and Caspase-8 Expression in Primary and Metastatic Head and Neck Squamous Cell Carcinoma and Their Prognostic Impact. PLoS One 5(8): e12178, 2010.

Beitler J, Muller S, Grist W, Corey A, Klein A, Johns M, Landry, Hudgins PA.Prognostic Accuracy of Radiologic Signs for Laryngeal Patients Undergoing Laryngectomy. J Clin Oncol 28: 2318-2322, 2010.

Skalova A, Sima R, Vanecek T, Müller S, Korabecna M, Nemcova J, Elmberger G, Leivo I, Passador-Santos F, Walter J, Rousarova M, Jedlickova K, Geierova M, Michal M. Acinic Cell Carcinoma with high-grade transformation. A report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/neu genes. Am J Surg Pathol 33:1137-1145, 2009.

Saba NF, Wang X, Müller S, Tighiouart M, Cho K, Nie S, Chen Z, Shin DM. Examining expression of folate receptor in squamous cell carcinoma of the head and neck (SCCHN) as a target for a novel nanotherapeutic drug. Head Neck 31:475-481, 2009.

Saba NF, Choi M, Muller S, Shin HJC, Tighiouart M, Papadimitrakopoulou VA, El-Naggar AK, Khuri FR, Chen Z, Shin DM. Role of Cyclooxygenase-2 in Tumor Progression and Survival of Head and Neck Squamous Cell Carcinoma. Cancer Prev Res 2: 823-829, 2009

Muller, Su L, Tighiouart M, Saba N, Zhang H, Shin DM, Chen Z. Distinctive E-cadherin and epidermal growth factor receptor expression in metastatic and non-metastatic head and neck squamous cell carcinoma: Predictive and prognostic correlation. Cancer 113, 97-107, 2008.

Muller S, Pan Y, Li R, Chi AC. Changing trends in the incidence of oral squamous cell carcinoma with particular reference to young patients, 1971-2006. The Emory University Experience. Head Neck Pathol 2, 60-66, 2008

Beadling C, Jacobson-Dunlop E, Hodi FS, Le C, Warrick A, Patterson J, Town A, Harlow A, Cruz F, Azar S, Rubin BP, Muller S, West R, Heinrich MC, Corless CL. KIT mutations in mucosal melanoma. Clin Can Res: 14(21);6821-6828, 2008

McLean N, Tighiouart M, Muller, S. Primary Mucosal Melanoma of the Head and Neck. Comparison of Clinical Presentation and Histopathologic Features of Oral and Sinonasal Melanoma. Oral Oncology 44, 1039-1046, 2008.

Muller, Su L, Tighiouart M, Saba N, Zhang H, Shin DM, Chen Z. Distinctive E-cadherin and epidermal growth factor receptor expression in metastatic and non-metastatic head and neck squamous cell carcinoma: Predictive and prognostic correlation. Cancer 113, 97-107, 2008.

Muller S, Pan Y, Li R, Chi AC. Changing trends in the incidence of oral squamous cell carcinoma with particular reference to young patients, 1971-2006. The Emory University Experience. Head Neck Pathol 2, 60-66, 2008.

Zhang H, Su L, Müller S, Tighiouart M, Xu Z, Zhang X, Shin HJC, Hunt, J, Sun S-Y, Shin DM, Chen Z(G). Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma. Br J Cancer 99, 1684-1694, 2008.

McLean JN, Nunley SR, Klass C, Moore CE, M¿ller S, Johnstone PAS. Combined modality therapy of esthesioneuroblastoma. Otolaryngol- Head Neck Surg 136(6):998-1002, 2007.

Vigneswaran N, Baucum DC, Wu J, Lou Y, Bouquot J, Muller S, Wolfgang Zacharias. Repression of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) but not its receptors during oral cancer progression. BMC Cancer 7:108, 2007.

Penner CR, Muller S. Head & neck amyloidosis. A clinicopathologic study of 15 cases. Oral Oncology 42:421-429.

Fowler BZ, Muller S, Chen AY, Johnstone PAS. Factors influencing long-term survival after salvage total laryngectomy after initial radiotherapy or conservative surgery. Head Neck 28:99-106, 2006.

Vigneswaran N. Wu J. Muller S. Zacharias W. Narendran S. Middleton L. Expression analysis of cystatin C and M in laser-capture microdissectioned human breast cancer cells--a preliminary study. Pathol Res Prac 200(11-12):753-62, 2005

Chi AC, S Muller. Peripheral odontogenic keratocyst: A case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:71-78, 2005

Zhang X, JL Hunt, DP Landsittel, S Muller, K Adler-Storthz, RL Ferris, DM Shin, A Chen. Correlation of protease-activated receptor-1 (PAR-1) with differentiation markers in squamous cell carcinoma of the head and neck and its implication in lymph node metastasis. Clin Can Res 10: 8451-8459, 2004

DelGaudio JM, Muller S. Diagnosis and treatment of supraglottic laryngeal paraganglioma: Report of a case. Head Neck 26:94-98, 2004.

Muller S, N Vigneswaran. Oral and maxillofacial pathology case of the month. Cicatricial pemphigoid (mucous membrane pemphigoid). Texas Dent J, 121:103, 2004.

DelGaudio JM, Swain R, Kingdom TT, Muller S, Hudgins P. Computed tomographic findings in patients with invasive fungal sinusitis. Arch Otolaryngol Head Neck Surg 129:236-240, 2003

Book Chapters -

Müller S. Section 4: Oral cavity (28 topics), Section 6: Jaw (2 topics). In:LDR Thompson, BM Wenig (eds.), Diagnostic Pathology: Head and Neck, Amirsys Publishing, 2011.

Bouquot J, Müller S, Nikai H. Lesions of the Oral Cavity. In: DR Gnepp (ed), Diagnostic Surgical Pathology of the Head and Neck. W. B. Saunders, Phila, PA, second edition, 2009; 191-308.

Müller S. Non-infectious ulcerative and vesiculoerosive lesions of the oral cavity. In: L. Barnes (ed.), Surgical Pathology of the Head and Neck, Informa Healthcare USA, Inc., NY, third edition, 2009; 243-265.

Müller S. Oral Precancer. In: Oral Cancer, Werning, J. W (ed.), Oral Cancer, Thieme, NY 2007; 8-18.

Muller S. Non-neoplastic lesions. In: LDR Thompson (ed), Head and Neck Pathology, Elsevier Science, Phila, PA 2006;