Jeannine T Holden, MD

Hematopathology

Associate Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

Staff Pathologist, Molecular Diagnostics Laboratory,, EUH, Emory Medical Laboratories, Atlanta, GA

Director, Flow Cytometry Laboratory, EUH, Emory Medical Laboratories, Atlanta, GA

Director, Hematopathology, Department of Pathology and Laboratory Medicine, EUH / Emory University School of Medicine, Atlanta, GA

Pathology Division(s):
Clinical Pathology

Email Address:
jholden@emory.edu

Education:

B.A.   B.A. with Distinction, Chemistry and French, University of Virginia, Charlottesville, VA, 1984 -

M.D.   M.D. cum laude, Emory University School of Medicine, Atlanta, GA, 1989 -

Research Interests:

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Diagnostic hematopathology, with particular emphasis on flow cytometric immunophenotyping. Minimal residual disease, interobserver variability in interpretation of flow data, and significance of light scatter properties are current areas of investigation. Collaborative efforts include characterization of ophthalmic lymphomas and a mouse tumor model for characterization of T suppressor cells.

Honors / Awards:

Janet M. Glasgow Memorial Achievement Citation, Emory University School of Medicine, 1989

Alpha Omega Alpha, 1988

Lange Book Award, Emory University School of Medicine, 1987

Echols Scholar, University of Virginia, 1980-1984

Specialty Boards:

1995 Certificate Certified in Anatomic and Clinical Pathology by American Board of Pathology, November

1997 Certificate Certified in Hematology by American Board of Pathology, August

Selected Publications:

Published and Accepted Research Articles -

Li S. Juco J. Mann KP. Holden JT. 2004. Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. Am J Clin Pathol 121(2):268-74, Feb.

Sharara N. Holden JT. Wojno TH. Feinberg AS. Grossniklaus HE. 2003. Ocular adnexal lymphoid proliferations: clinical, histologic, flow cytometric, and molecular analysis of forty-three cases. Ophthalmology. 110(6):1245-54, Jun.

Juco J. Holden JT. Mann KP. Kelley LG. Li S. 2003. Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry. Am J Clin Pathol 119(2):205-12, Feb.

O'Keefe JS. Sippy BD. Martin DF. Holden JT. Grossniklaus HE. 2002. Anterior chamber infiltrates associated with systemic lymphoma: report of two cases and review of the literature. Ophthalmology. 109(2):253-7, 2002, Feb.

Feinberg AS, Spraul CW, Holden JT, Grossniklaus HE. 2000. Conjunctival lymphocytic infiltrates associated with Epstein-Barr virus. Ophthalmol 107:159-163, Jan.

Zhou M. Gu L. Holden J. Yeager AM. Findley HW. 2000. CD40 ligand upregulates expression of the IL-3 receptor and stimulates proliferation of B-lineage acute lymphoblastic leukemia cells in the presence of IL-3. Leukemia 14(3):403-11, Mar.

Veien M, Szlam F, Holden JT, Yamaguchi K, Denson DD, Levy JH. 2000. Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells. Anesthesiol 92:1074-1081, Apr.

LaMontagne KR Jr, Moses MA, Wiederschain D, Mahajan S, Holden J, Ghazizadeh H, Frank DA, Arbiser JL. 2000. Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells. Am J Pathol 157(6):1937-45, Dec.

Waller EK, Ship AM, Mittelstaedt S, Murray TW, Carter R, Kakhniashvili I, Lonial S, Holden JT, Boyer MW. 1999. Irradiated donor leukocytes promote engraftment of allogeneic bone marrow in major histocompatibility complex recipients without causing graft-versus-host disease. Blood 94:3222-3233.

Lonial S, Bilodeau PA, Langston AA, Lewis C, Mossavi-Sai S, Holden JT, Waller EK. 1999. Acquired amegakaryocytic thrombocytopenia treated with allogeneic BMT: a case report and review of the literature. Bone Marrow Transpl 24:1337-1341.

Zeder K, Waller EK, Redei I, Connaghan G, Fleming WH, Geller RB, Heffner LT, Hillyer CD, Holden J, Holland K, Jones W, McCollum J, Mogul M, Phillips C, Rodey G, Wingard JR, Winton E, Yeager YM, Devine S. 1998. Impact of donor lymphocyte infusion for hematological malignancy relapsed after allogeneic bone marrow transplantation. Cancer Res Therapy and Control 5:221-228.

Miraglia S, Godfrey W, Yin AH, Atkins K, Warnke R, Holden JT, Bray RA, Waller EK, Buck DW. 1997. A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood 90:5013-5021.

Holden JT, Geller RB, Farhi DC, Holland HK, Stempora LL, Phillips CN, Bray RA. 1995. Characterization of Thy-1 (CDw90) expression in CD34+ acute leukemia. Blood 86:60-65.

Schwartz DA, Visvesvara GS, Leitch GJ, Tashjian L, Pollack M, Holden J, Bryan RT. 1993. Pathology of symptomatic microsporidial (Encephalitozoon hellem) bronchiolitis in the acquired immunodeficiency syndrome: a new respiratory pathogen diagnosed from lung biopsy, bronchoalveolar lavage, sputum, and tissue culture. Hum Pathol 24:937-943.

Other Publications -

Holden JT, Bray RA, Braylan R, Chen SS, Duenzl ML, Frey T, Kamihira S, Ludwig WD, Orfao A, Ratei R, Tomonaga M, Borowitz MJ. 2000. Interobserver variability in the assessment of flow cytometric immunophenotyping of hematolymphoid neoplasms. BLOOD 96 (11): 3097.

Bearden CL, Mann KP, Duenzl ML, Holden JT. 2000. Grading of follicular lymphomas: correlation between histologic assessment and measurement of light scatter properties as measured by flow cytometry. Mod Pathol 13:143A.

Bucur SZ, Heffner LT, Langston AA, Redei J, Waller EK, Winton EF, Holden JT, Smith KJ. 1999. Autologous peripheral blood stem cell (PBSC) transplantation in AML: Outcome and flow cytometric analysis of the PBSC product. Blood 94:5006.

Fiebelkorn KR, Holden JT, Bray RA. 1999. Lack of CD45 expression in adult precursor B-lineage acute lymphoblastic leukemia may predict improved outcome. Am J Clin Pathol 112:92.

Feinberg AS, Grossniklaus HE, Holden JT, Spraul CW. 1999. Lymphoproliferative lesions of the conjunctiva associated with Epstein-Barr virus in children. Investigative Ophthalmol & Visual Science 40:3415B273.

Guy CD, Bray R, Holden J, Farhi D. 1998. Expression of CD11b, CD11c, and CD15 in acute promyelocytic leukemia patients: in vivo effects of all-trans retinoic acid treatment. Am J Clin Pathol 109: 476.

Bray RA, Holden JT. 1997. Flow cytometric detection of minimal and residual hematopoietic disease. Oral presentation at Applications of Flow Cytometry in Blood and Marrow Stem Cell Transplantation, Stone Mountain, GA, April 3-5.

Huang Y, Kim CN, Holden J, Amarante-Mendes GP, Winton EF, Perkins CL, Green DR, Bhalla K. 1997. Ectopic expression of p185 bcr- abl in human AML HL-60 cells blocks myeloid but allows erythroid differentiation and growth inhibition due to low dose Ara-C or ATRA. Blood 90: 278b.

Holland HK, Bray RA, O'Toole K, Holden JT, Connaghan DG, Heffner LT, Waller EK, Winton EF, Yeager YM. 1997. Presence of minimal residual disease (MRD) in acute myelogenous leukemia (AML) patients pre-allogeneic bone marrow transplantation (BMT) is associated with a lower relapse-free survival (RFS). Exp Hematol 25: 905.

Slade BA, Vogt RF, Marti GE, Bray RA, Holden JT. 1997. VOCs and PCBs: risk factors for B-cell lymphoproliferative disorders? Blood 90:270b.

Waller EK, Redei I, Yeager A, Winton EF, Heffner T, Hillyer C, Carter R, Ascensao J, Holland K, Connaghan G, Phillips C, Holden J, Guerriero A, Murray T, Worford L, Jurickova I, Boyer M. 1997. 7.5 Gy irradiation attenuates the graft vs host disease (GvHD) potential of allogeneic lymphocytes while preserving anti-leukemic activity in pre-clinical and clinical studies. Blood 90: 547a.

Holden JT, Bray RA. 1996. Combined phenotypic and genotypic assessment for the detection of minimal residual disease in hematolymphoid malignancies. Clin Immunol Newslet 16:151-155.

Holden JT, Farhi DC, Hendrix L, Stempora L, Bray RA. 1996. Mantle cell lymphoma vs small lymphocytic lymphoma: diagnosis by surface light chain density. Lab Invest 74: 113A.

Lin L, Holden JT, Jones TW, Holland HK, Yeager AM, Waller EK. 1996. Ethnic and racial differences influence cell yields from bone marrow collections. Blood 88: 397a.

Holden JT, Farhi DC, Bray RA, Stempora LL, Lewis MM. 1995. Malignant lymphoma diagnosis by fine needle aspiration with flow cytometry. Am J Clin Pathol 103:511.

Holden JT, Farhi DC, Chenggis ML, Abbott KL. 1995. bcl-2 analysis of follicular lymphoma by Southern blotting and polymerase chain reaction. Am J Clin Pathol 103:511.

Holden JT, Bray RA, Yeager AM, Farhi DC. 1995. Thy-1 (CDw90) expression in pediatric T-cell lymphoblastic malignancy. Am J Clin Pathol 104:348.

Holden JT, Bray RA, Yeager AM, Farhi DC. 1995. Thy-1 (CDw90) expression in pediatric T-cell lymphoblastic malignancy. Am J Clin Pathol 104:348

Holden JT, Farhi DC. Gene rearrangement analysis of small samples. Check Sample ST94-5, ASCP Press, 1994.

Holden J, Farhi D, Abbott K. bcl-2 detection by the polymerase chain reaction. Poster presentation at Molecular Pathology 1994, Bethesda, MD, 1994.

Holden JT, Geller RB, Farhi DC, Holland HK, Stempora LL, Bray RA. 1994. Utility of Thy-1 expression in CD34+ acute leukemia. Blood 84:310a.