Pathology Faculty Member

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    Clinical and Experimental Pathology
    1364 Clifton Rd. N.E. Rm. D-655
    Atlanta, GA 30322
    404 712-5869 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    John D Roback, MD, PhD

    Transfusion Medicine

    Associate Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Director, Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine

    Medical Director, Emory University Hospital, Blood Bank

    Medical Director, Emory Healthcare School of Medical Technology


    Pathology Division(s):
    Clinical Pathology
    Experimental Pathology


    Email Address:
    jroback@emory.edu


    Education:

    Bachelor   Biophysics,The Johns Hopkins University, Baltimore, MD, 1980 - 1984

    Medical Doctor   The University of Chicago, Chicago, IL, - 1994

    Doctorate   Experimental Pathology, The University of Chicago, Chicago, IL, 1984 - 1994



    Research Interests:

    - Overview
    The focus of my laboratory is basic and translational research investigations with an emphasis on improved Transfusion Medicine clinical practice. The primary ongoing projects that have been or are currently NIH-funded include: (i) Utilization of murine models of lethal murine cytomegalovirus (MCMV) disease to develop improved, clinically applicable methods for adoptive antiviral immunotherapy and post-transplant vaccination to for bone marrow transplant recipients; (ii) Development of novel, innovative methods and devices to perform pretransfusion testing of blood components; and (iii) Development of improved PCR methods for screening blood and hematopoietic stem cell products for CMV infectivity.



    Clinical Focus:

    Improving the safety and efficacy of blood transfusion and hematopoietic stem cell transplantation. Current positions: Associate Professor (tenured) in the Department of Pathology and Laboratory Medicine, Associate Director of the Emory Center for Transfusion and Cellular Therapies, Associate Director of the Emory University Hospital Blood Bank, and Associate Director of the Stem Cell Processing Laboratory at Emory University Hospital. National leadership positions: Co-Chairman of the NIH/NHLBI Global Blood Safety and Availability Strategic Planning Committee, Chairman of the AABB Clinical Transfusion Medicine Committee, and Editor of the AABB Technical Manual.


    Honors / Awards:

    Golden Apple Teaching Award, 2002-2003

    New Enterprise Award (1st place out of 70 entries), 2001

    National Blood Foundation Scholar, 2000

    Specialty Boards:

    2001  Diplomate, American Board of Pathology in Clinical Pathology


    2002  Diplomate, American Board of Pathology in Blood Banking and Transfusion Medicine


    Selected Publications:

    Published and Accepted Research Articles -

    Roback, J.D., Caldwell, S., Carson, J., Davenport, R., Drew, M.J., Eder, A., Fung, M., Hamilton, M., Hess, J. Luban, N., Perkins, J., Sachais, B., Shander, A., Silverman, T., Snyder, E., Tormey, C., Waters, J., and Djulbegovic, B.


    Murad, M.H., Stubbs, J.R., Gandhi, M.J., Wang, A.T., Paul, A., Erwin, P.J., Montori, V.M., and Roback, J.D. (2010) The effect of plasma transfusion on morbidity and mortality: A systematic review and meta-analysis.


    Djulbegovic, B., Trikalinos, T.A., Roback, J.D., Chen, R., and Guyatt, G. (2009) Impact of quality of evidence on the strength of recommendations: an empirical study. BMC Health Services Research. 9:120, 1-6.


    Onyeagocha, C., Hussein, S., Roback, J.D., and Gewirtz, A.T. (2009) Latent cytomegalovirus infection exacerbates experimental colitis. Am. J. Pathology. In press.


    Fowlkes. A.L., Brown, C., Amin, M.M., Roback, J.D., Downing, R., Nzaro, E., Mermin, J., Hladik, W., and Dollard, S.C. (2009) Quantitation of HHV-8 antibody in patients transfused with HHV-8 seropositive blood. Transfusion. In press.


    Hossain, M.S., Roback, J.D., and Waller, E.K (2008) Host and donor immune responses contribute to anti-viral effects of amotosalen-treated donor lymphocytes following early post-transplant CMV infection. J. Immunol. 180(10), 6892-902.


    Hendrickson, J.E, Roback, J.D., Hillyer, C.D., Easley, K.A., and Zimring, J.C (2008) Discrete toll like receptor agonists have differential effects on alloimmunization to transfused red blood cells. Transfusion. 48(9), 1869-77.


    Ninan, M.J., Flowers, C.R., Roback, J.D., Arellano, M.L., Waller, E.K. (2007) Post-transplant thrombopoiesis predicts survival in patients undergoing autologous hematopoietic progenitor cell transplantation. Biology of Blood and Marrow Transplantation. 13(8), 895-904.


    Hendrickson, J.E, Chadwick, T.E., Roback, J.D., Hillyer, C.D., and Zimring, J.C (2007) Inflammation Enhances Consumption and Presentation of Transfused RBC Antigens by Dendritic Cells. Blood. 110(7), 2736-43.


    Zimring, J.C., Spitalnik, S.L., Roback, J.D., and Hillyer, C.D. (2007) Transfusion induced auto- antibodies and differential immunogenicity of blood group antigens: A novel hypothesis. Transfusion. 47(12), 2189-96.


    Hicks, M.L., Lonial, S., Langston, A., Flowers, C., Roback, J.D., Smith, K.J., Sai, S.M., Teagarden, D., Hamilton, E.S., and Waller, E.K. (2007) Optimizing the timing of chemotherapy for mobilizing autologous blood hematopoietic progenitor cells. Transfusion. 47(4), 629-35.


    Hossain, M.S., Roback, J.D., Pollack, B.P., Jaye, D.L., Langston, A., and Waller, E.K (2007) Chronic GvHD decreases anti-viral immune responses in allogeneic BMT. Blood. 109(10), 4548- 4556.


    Roback, J.D., Su, L., Newman, J.L., Saakadze, N., Lezhava, L., and Hillyer, C.D. (2006) Transfusion-transmitted CMV infection in a murine model: Characterization of CMV-infected donor mice. Transfusion (in press).


    Hendrickson, J.E., Desmarets, M., Deshpande, S.S., Chadwick, T., Hillyer, C.D., Roback, J.D., and Zimring, J.C. (2006) Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells. Transfusion (in press).


    Roback, J.D., Conlan, M., Drew, W.L., Ljungman, P., Nichols, W.G., and Preiksaitis, J.K. (2006) The role of photochemical treatment with amotosalen and UV-A light in the prevention of transfusion-transmitted cytomegalovirus infections. Transf. Med. Rev. 20(1), 45-56.


    Sheppard, C.A., Roback, J.D., and Hillyer, C.D. (2005) Transfusion-transmitted cytomegalovirus infection: Consideration toward an optimal plan for its mitigation. Blood. Ther. Med. 5(1), 6-14.


    Hossain, M.S., Roback, J.D., Lezhava, L., Hillyer, C.D., and Waller, E.K. (2005) Amotosalen treated donor T-cells have polyclonal antigen specific long-term function without GvHD after allogeneic bone marrow transplantation. Biology of Blood and Marrow Transplantation. 11(3), 169-180.


    Roback, J.D., Caliendo, A.M., Newman, J.L., Sgan, S., Saakadze, N., Gillespie, T.W., Lane, T.A., Kurtzberg, J., and Hillyer, C.D. (2005) Comparison of CMV PCR and serology for screening umbilical cord blood components. Transfusion. 45(11), 1722-1728.


    Zimring, J.C., Hair, G., Chadwick, T.E., Deshpande, S., Anderson, K., Hillyer, C.D., and Roback, J.D. (2005) Non-hemolytic antibody induced loss of erythrocyte surface antigen. Blood. 106(3), 1105-1112. [see accompanying editorial: Spitalnik, S.L. (2005) Yin and yang in transfusion medicine. Blood 106(3), 771-2]


    Schuetz, A.N., Kost, C., and Roback, J.D. (2005) Transfusion-transmitted Streptococcus pneumoniae from a single donor platelet apheresis unit. Journal of Clinical Apheresis. 20, 86-87.


    Jordan, C.T., Saakadze, N., Newman, J.L., Lezhava, L., Maiers, T., Hillyer, W.M., Roback, J.D., and Hillyer, C.D. (2004) Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model. Transfusion. 44(8), 1159-1165.


    Zimring, J.C., Chadwick, T.E., Hillyer, C.D., and Roback, J.D. (2004) Effect of mediators of innate immunity and inflammation on CD8+ veto cells. Transplantation. 78(11), 1597-1600.


    Jordan, C.T., and Roback, J.D. (2004) Separating antiviral and GvHD activities of donor T-cells prior to bone marrow transplantation. Immunologic Research. 29, 209-218.


    Schuetz, A.N., Hillyer, K.L., Roback, J.D., Hillyer, C.D. (2004) Leukoreduction filtration of blood with sickle cell trait. Transf. Med. Rev. 18(3), 168-176.


    Roback, J.D., Barclay, S., and Hillyer, C.D. (2004) Improved methodology for fluorescence cytometric immunohematology testing. Transfusion. 44(2), 187-196.


    Hillyer, C.D., Roback, J.D., Hillyer, K.L., Josephson, C.D., and Page, P.L. (2004) Description and investigation of White Particulate Matter (WPM) in AS-1 pRBC units. Transfusion. 44(7), 977-983.


    Waller, E.K., Giver, C.R., Rosenthal, H., Somani, J., Langston, A., Lonial, S., Roback, J., Li, J.-M., Hossain, M.S., and Redei, I. (2004) Facilitating T-cell immune reconstitution after haplo-identical transplantation in adults. Blood Cells, Molecules and Diseases. 33(3), 233-237.


    Schuetz, A., and Roback, J.D. (2003) Toward prevention of transfusion-transmitted infectious diseases. Exp. Rev. Anti-Infect. Ther. 1(2), 267-274.


    Roback, J.D., Hossain, M.S., Lezhava, L., Gorechlad, J.W., Alexander, S.A., Jaye, D., Mittelstaedt, S., Talib, S., Hearst, J.E., Hillyer, C.D., and Waller, E.K. (2003) Allogeneic T-cells treated with amotosalen prevent lethal CMV disease without producing GvHD following BMT. J. Immunol. 171, 6023-6031.


    Roback, J.D., Drew, W.L., Laycock, M.E., Todd, D., Hillyer, C.D., and Busch, M.P. (2003) CMV DNA is rarely detected in healthy blood donors using validated PCR assays. Transfusion 43(3), 314-321.


    Roback, J.D., Barclay, S., and Hillyer, C.D. (2003) An automatable format for accurate immunohematology testing by flow cytometry. Transfusion 43(7), 918-927.


    Roback, J.D. (2002) CMV and blood transfusions. Revs. Med. Virology 12, 211-219.


    Roback, J.D., Hillyer, C.D., Drew, W.L., Laycock, M.E., Luka, J., Mocarski, E.S., Slobedman, B., Smith, J.W., Soderberg-Naucler, C., Todd, D., Woxenius, S., and Busch, M.P. (2001) Multicenter evaluation of PCR methodologies to detect cytomegalovirus (CMV) DNA in blood donors. Transfusion 41(10), 1249-1257.


    Boss, V., Roback, J.D., Young, A., Vogt, D. Roback, L.J., Vogt Weisenhorn, D.M., Medina-Flores, R., and Wainer, B.H. (2001) Nerve growth factor, but not epidermal growth factor, increases Fra-2 expression and alters Fra-2/JunD binding to AP-1 and CREB binding elements in pheochromocytoma (PC12) cells. J. Neurosci. 21(1), 18-26.


    Roback, J.D., Bray, R.A., and Hillyer, C.D. (2000) Longitudinal monitoring of leukocyte subsets in packed red blood cell units after filtration: Implications for transfusion-transmitted infections. Transfusion 40(5), 500-6.


    Book Chapters -

    Roback, J.D. (2006) Human Herpesvirus Infections. In: Blood Banking and Transfusion Medicine (2nd Edition), Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., and Roback, J.D., eds., Churchill Livingstone, New York, NY (in press).


    Roback, J.D. (2004) Preparation of Blood Components to Reduce CMV and Other Infectious Risks. In: Handbook of Pediatric Transfusion Medicine, pp. 93-99, Hillyer, C.D., Strauss, R., and Luban, N.L.C., eds., Academic Press, San Diego, CA.


    Roback, J.D. (2003) Human Herpesvirus Infections. In: Blood Banking and Transfusion Medicine, pp. 465-485, Hillyer, C.D., Silberstein, L.E., Ness, P.M., and Anderson, K.C., eds., Churchill Livingstone, New York, NY.


    Roback, J.D. (2001) CMV and Other Virus "Safe" Products. In: Handbook of Transfusion Medicine, pp. 129-135, Hillyer, C.D., Hillyer, K.L., Strobl, F.J., Jeffries, L.C., and Silberstein, L.E., eds., Academic Press, San Diego, CA.


    Roback, J.D., and Hillyer, C.D. (2001) Platelets and Related Products. In: Handbook of Transfusion Medicine, pp. 53-61, Hillyer, C.D., Hillyer, K.L., Strobl, F.J., Jeffries, L.C., and Silberstein, L.E., eds., Academic Press, San Diego, CA.


    Roback, J.D. (2001) CMV and Other Herpesviruses. In: Handbook of Transfusion Medicine, pp. 285-292, Hillyer, C.D., Hillyer, K.L., Strobl, F.J., Jeffries, L.C., and Silberstein, L.E., eds., Academic Press, San Diego, CA.


    Roback, J.D. and Hillyer, C.D. (1999) Therapeutic use of blood components. In: Conn's Current Therapy 1999, pp. 446-451, R.E. Rakel, ed., WB Saunders, Philadelphia, PA.


    Bucur, S.Z., Roback, J.D. and Hillyer, C.D. (1999) Hematopoietic growth factors. In: Scientific Basis of Transfusion Medicine - Implications for Clinical Practice, 2nd Edition, pp. 45-58, Anderson, K.C. and Ness, P.M., eds., WB Saunders, Philadelphia, PA.


    Books Edited and Written -

    Blood Banking and Transfusion Medicine (2nd Edition), Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., and Roback, J.D., eds., Churchill Livingstone, New York, NY (in press).


    Other Publications -

    Mintz, P., Roback, J.D., (2005) Editorial: The National Blood Foundation: 20 years of supporting pioneering transfusion medicine research. Transfusion. 45(8S), i.