Pathology Faculty Member

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  • Contact Information:

    Grady Health System Laboratory Administration
    80 Jesse Hill Jr Drive SE Room 1G053
    Atlanta, GA 30303
    404-616-4800 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Karen P Mann, MD, PhD

    Hematopathology

    Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Chief Clinical Pathology, Grady Health System

    Medical Director, Clinical Laboratories, Grady Health System

    Director, Molecular Genetic Pathology Fellowship Program, Emory University Hospital


    Pathology Division(s):
    Clinical Pathology


    Email Address:
    kmann@emory.edu


    Education:

      University of Massachusetts, Amherst, MA, 1976 - 1978

    A.B., magna cum laude   Harvard University, Boston, MA, 1978 - 1980

    MD, PhD   Tufts University School of Medicine, Sackler School of Graduate Studies, Boston, MA, 1981 - 1988



    Research Interests:

    - Overview -
    My research interests focus on the development of new molecular diagnostic tests and flow cytometric targets which can aid in the diagnosis, subclassification, determination of prognosis, and treatment monitoring in patients with hematopoietic neoplasms. In addition, I am interested in evaluation of the usefulness of newly identified mutations both as diagnostic targets as well as possible targets of directed therapies. I am also interested in the monitoring and significance of minimal residual disease in different hematopoietic disorders.



    Clinical Focus:

    My clinical focus is in the area of neoplastic and non-neoplastic hematopathology of adults and children with an emphasis on a multifaceted approach including morphology, immunohistochemistry, flow cytometric immunophenotyping, fluorescence in situ hybridization, cytogenetics, and molecular testing. This approach is used to diagnosis the full range of hematopoietic malignancies and to evaluate for residual or recurrent disease following treatment. As Director of Molecular Hematopathology, I additionally have a leading role in supervising the development and evaluation of new molecular hematopathology tests in order to maintain a state-of-the-art diagnostic hematopathology laboratory.


    Honors / Awards:

    National Research Service Postdoctoral Fellowship Award, NIH, 1990

    National Science Foundation Undergraduate Research Fellowship

    , 1979

    Specialty Boards:

    1993 Certificate Anatomic Pathology; American Board of Pathology


    1997 Certificate Special Qualification in Hematopathology; American Board of Pathology


    2003 Certificate Molecular Genetic Pathology; American Board of Pathology


    Selected Publications:

    Published and Accepted Research Articles -

    Mann KP. 2010. Gene patents: a view from the clinical laboratory. Expert Rev Mol Diagn 10:123-125, Mar.


    Schniederjan SD, Li S, Saxe DF, Lechowicz MJ, Lee KL, Terry PD, Mann KP. 2010. A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma. Am J Clin Pathol 133:718-726, May.


    Mann KP. 2010. Gene patents: perspectives from the clinical laboratory. Mol Diagn Ther 14:137-140.


    Lima L, Bernal-Mizrachi L, Saxe D, Mann KP, Tighiouart M, Arellano M, Heffner L, McLemore M, Langston A, Winton E, Khoury HJ. 2010. Peripheral blood monitoring of chronic myeloid leukemia during treatment with Imatinib, second-line agents and beyond. Cancer 117:1245-1252, Mar.


    Jima DJ, Zhang J, Jacobs C, Richards KL, Dunphy C, Choi WL, Au WY, Srivastava G, Czader, MB, Rizzieri D, Lagoo AS, Mann KP, Flowers CR, Khoury HJ, Sunay D, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson M, Gill JI, Kahl BS, Gao Y, Xie B, Patel A, Wu H, ZHU J, Lugar PL, Lipsky PE, Dressman H, Chadburn A, Dave SS. 2010. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Blood 116: 118-127.


    Pullarkat ST, Pullarkat V, Kroft SH, Wilson CS, Ahsanuddin AN, Mann KP, Thein M, Grody WW, Brynes RK. 2009. Systemic mastocytosis associated with t(8;21)(q22;q22) acute myeloid leukemia. J Hematop 2:27-33, Mar. [Epub 2009 Feb 10] (www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s12308-009-0023-2, Feb. 11, 2009, Springer)


    Li S, Mann KP, Holden JT. 2008. Case Report: Composite small lymphocytic lymphoma and extramedullary myeloid tumor: A potential diagnostic pitfall. Int J Clin Exp Pathol 1:91-97, Jan. (www.ijcep.com/IJCEP704000, Jan 2008)


    Murali S, Winton E, Waller EK, Heffner LT, Lonial S, Flowers C, Kaufman J, Arellano M, Lechowicz MJ, Mann KP, Khoury HJ, Langston AA. 2008. Long-term progression-free survival after early autologous transplantation for mantle cell lymphoma. Bone Marrow Transplantation 42:529-534, Oct. (www.nature.com/bmt, July, 2008)


    Kost CB, Holden, JT, and Mann KP. 2008. Marginal zone B-cell lymphoma: A retrospective immunophenotypic analysis. Cytometry Part B 74B:282-286. Sep. (www.interscience.wiley.com, May 2008)


    Arbiser JL, Mann KP, Losken EM, Cohen C, Reddy K, Kokko K, Pollack B, Fan CY, O'Reilly F. 2006. Presence of p16 hypermethylation and Epstein-Barr virus infection in transplant-associated hematolymphoid neoplasm of the skin. J AM Acad Dermatol 55:794-8, Nov. [Epub 2006 Sep 1]


    Rizzieri DA, Wadleigh MJ, Wikstrand CJ, Mann KP, Sen F, Peterson BL, Niedzwiecki D, Proia AD, Bigner DD. 2005. Tenascin and microvessel stromal changes in patients with non-hodgkins lymphoma are isolated to the sites of disease and vary in correlation to disease activity. Leukemia & Lymphoma 46:1455-1462, Oct.


    Feldman AL, Berthold F, Arceci RJ, Abramowsky C, Shehata BM, Mann KP, Lauer SJ, Pritchard J, Raffeld M, Jaffe ES. 2005. Clonal relationship between precursor T-lymphoblastic leukaemia/lymphoma and langerhans-cell histiocytosis. Lancet Oncol 6:435-437, Jun.


    Alvarado CS, Straus SE, Li S, Dale JK, Mann K, Le A, Lauer SJ. 2004. Autoimmune lymphoproliferative syndrome: a cause of chronic splenomegaly, lymphadenopathy, and cytopenias in children. Report on diagnosis and management of five patients. Pediatr Blood Cancer 43:164-169, Aug.


    Halkos ME, Miller JI, Mann KP, Miller DL, Gal AA. 2004. Thoracic presentations of post-transplant lymphoproliferative disorders. Chest 126:2013-2020, Dec.


    Edelstein E, Gal AA, Mann KP, Miller JI Jr, Mansour KA. 2004. Primary solitary endobronchial plasmacytoma. Ann Thorac Surg 78:1448-1449, Oct.


    Edelstein E, Gal AA, Mann KP, Miller JI Jr, Mansour KA. 2004. Primary solitary endobronchial plasmacytoma. Ann Thorac Surg 78:1448-1449, Oct.


    Li S, Juco J, Mann KP, Holden JT. 2004. Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. Am J Clin Pathol 121:268-274, Feb.


    Li S, Mann KP, Holden JT. 2004. T-cell-rich B-cell lymphoma presenting in the spleen: clinicopathologic analysis of 3 cases. Int J Surg Pathol 12:31-37, Jan.


    Juco J, Holden JT, Kelly LG, Mann KP, Li S. 2003. Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry. Am J Clin Pathol 119:205-212, Feb.


    Sen F, Mann KP, Medeiros LJ. 2002. Multiple myeloma in association with sarcoidosis: A case report and review of the literature. Arch Pathol Lab Med 126:365-368, Mar.


    Liu K, Stern RC, Rogers RT, Dodd LG, Mann KP. 2001. Diagnosis of hematopoietic processes by fine-needle aspiration in conjunction with flow cytometry: A review of 127 cases. Diagn Cytopathol 24:1-10, Jan.


    Qumsiyeh MB, Cheng C, Eyre J, Mann KP, Zhang XX. 2000. Tetrasomy 8 evolving into a segmental triplication 8q in a case of acute monocytic leukemia. Cancer Genetics Cytogenetics 116:74-76, Jan.


    Morphew E, Nuckols JD, Mann KP, Howell DN, Robboy SJ, Stenzel TT. 1999. Evaluation of an automated technique for identification of extraneous tissue in formalin-fixed surgical specimens. Lab Invest 79:1135.


    Lin WC, Moore JO, Traweek ST, Mann KP, Smith C. 1999. Post transplant CD8+ gamma delta T-cell lymphoma associated with human herpes virus-6 infection. Leuk Lymphoma 33:377-384.


    Murray CK, Estey E, Paietta E, Howard RS, Pierce S, Edenfield J, Mann KP, Bolan C, Byrd JC. 1999. CD56 expression in acute promyelocytic leukemia: A possible indicator of poor treatment outcome? J Clin Oncol 17: 293-397.


    Liu K, Mann KP, Garst JL, Dodd LG, Olatidoye BA. 1999. Diagnosis of post-transplant granulocytic sarcoma by fine needle aspiration cytology and flow cytometry. Diagn Cytopathol 20: 85- 89.


    Liu K, Mann KP, Vitellas KM, Paulson EK, Nelson RC, Gockerman JP, Dodd LG. 1999. Fine needle aspiration with flow cytometric immunophenotyping for primary diagnosis of intra-abdominal lymphomas. Diagn Cytopathol 21:98-104.


    Liu K, Coogan AC, Mann KP. 1998. Fine needle aspiration of large cell lymphoma in a patient with agnogenic myeloid metaplasia: a case report and review of the literature. Diagn Cytopathol 19: 205-209.


    Perry BP, Gregg CM, Myers S, Lilly S, Mann KP, Prieto V. 1998. Rosai-Dorfman disease (extranodal sinus histiocytosis) in a patient with HIV. Ear, Nose, & Throat Journal 77:855-858.


    Mann KP, DeCastro CM, Liu J, Moore JO, Bigner SH, Traweek ST. 1997. Neural cell adhesion molecule (CD56)-positive acute myelogenous leukemia and myelodysplastic and myeloproliferative syndromes. Am J Clin Pathol 107:653-660.


    Bottom KS, Adams DM, Mann KP, Ware RE. 1997. Trilineage hematopoietic toxicity associated with valproic acid therapy. J Pediatric Hematology Oncology 19:73-76.


    Mann KP, Liu J, Bigner SH, Moore JO, Traweek ST. 1996. CD56 (N-CAM) expression in acute non-lymphoid leukemia (ANLL) and myelodysplastic syndrome (MDS). Lab Invest 74:675.


    Horvatinovich JM, Sparks SD, Mann KP. 1996. Establishing a pure lymphocyte gate for subset analysis by flow cytometry. Cytometry 26:172-177.


    Rizzieri DA, DeCastro CM, Mann KP, Moore JO. 1995. T cell lymphoblastic leukemia with mediastinal mass and c-kit expression. Blood 86:3095.


    Mann KP, Hall B, Kamino H, Borowitz MJ, Ratech H. 1995. Neutrophil-rich Ki-1 positive anaplastic large cell malignant lymphoma. Amer J Surg Pathol 19:407-416.


    Mann KP, Hall B, Kamino H, Borowitz MJ, Ratech H. 1994. Neutrophil-rich Ki-1 positive anaplastic large-cell malignant-lymphoma. Lab Invest 70:A114.


    Mann KP, Weiss EA, Nevins JR. 1993. Alternative poly (A) site utilization during adenovirus infection coincides with a decrease in the activity of a poly (A) site-processing factor. Mol Cell Biol 13:2411-2419.


    Mann KP, Thorley-Lawson DA. 1987. Posttranslational processing of the Epstein-Barr virus-encoded p63/LMP protein. J Virol 61:2100-2108.


    Tischler AS, Mobtaker H, Mann KP, Nunnemacher G, Jason WJ, Dayal Y, Delellis RA, Adelman L, Wolfe HJ. 1986. Anti-lymphocyte antibody Leu-7 (HNK-1) recognizes a constituent of neuroendocrine granule matrix. J Histochem Cytochem 34:1213-1216.


    Thorley-Lawson DA, Mann KP. 1985. Early events in Epstein-Barr virus infection provide a model for B cell activation. J Exp Med 162:45-59.


    Mann KP, Staunton D, Thorley-Lawson DA. 1985. Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells. J. Virol 55: 710-720.


    Book Chapters -

    Mann KP, Saxe, DF. 2010. Molecular Pathology of Acute Myeloid Leukemias. In: Crisan, D, Ed: Hematopathology: Genomic Mechanisms of Neoplastic Diseases: Springer/ Humana Press.


    Mann KP, McLendon RE, Provenzale J. 1999. Malignant lymphomas and hematopoietic neoplasms of the central nervous system. In McLendon, RE, Bigner, DD, Bigner, SH and Provenzale, J, Eds: Pathology of Tumors of the Central Nervous System: A Guide to Histologic Diagnosis, London: Edward Arnold.


    Patel DD, Fong AM, Mann KP, Sundy JS, Whichard LP. 1997. CD166 Workshop: Tissue distribution and functional analysis of antibodies reactive with CD166, a ligand for CD6. In: Leucocyte Typing VI, T. Kishimoto, et al., eds. 461-464.


    Other Publications -

    Park SI, Bell J, Mann KP, Holden JT. CD13 Expression by IGM-Producing Low Grade B-Cell Lymphomas. Modern Path 18:245a.


    Jacobs CL, Patel A, Jima D, Liu Q, Greenough A, Zhang J, Dunphy C, Richards K, Choi W, Srivsatava G, Au W, Evens AM, Gordon LI, Czader M, Rizzieri DA, Lagoo AS, Mann KP, et al. 2010. Alternative Splicing Is a Major Mechanism of Gene Regulation In Diffuse Large B Cell Lymphoma. ASH Annual Meeting Abstracts. 116(21):803, Nov.


    Ramji1 RT, Hill CE, Khoury HJ, Lima L, Mann K. 2010. B-Lymphoblastic Leukemia/ Lymphoma with t(9;22)(q34;q11.2): Monitoring of BCR-ABL1 transcript level by Q-RT-PCR, correlation with treatment and other methods of MRD monitoring. J Molecular Diagnostics 12:869.


    Khoury HJ, Lima L, Saxe D, Mann KP, Arellano M, Heffner L, Bernal-Mizrachi L, McLemore M, Langston A, Winton E. 2009. Monitoring chronic myeloid leukemia (CML) response to tyrosine kinase inhibitors (TKI) and homoharringtonine (HHT) using peripheral blood (PB) fluorescence in situ hybridization (FISH) and quantitative RT-PCR (Q-PCR): Are bone marrow biopsies still needed? J Clin Oncol 27:15s, (suppl; abstr 7064).


    Carter AB, Schniederjan S, Mann, K. 2009. Software for the Laboratory: The Blood and Bone Marrow Counter. (Abstract) Arch Pathol Lab Med 133:1150, July.


    Lima L, Assouline SE, Saxe D, Mann K, McLemore M, Souza L, Arellano M, Winton EF, Bernal-Mizrachi L, Khoury HJ. 2009. Does pre-imatinib (IM) fluorescence in situ hybridization (FISH) predict myelosuppression and outcomes in chronic myeloid leukemia (CML)? J Clin Oncol 27:15s, (suppl; abstr 7071).


    Bradley KT, Rosado J, Mann KP. 2008. Evaluation of Signature┬┐ Primers and Signature┬┐ Probes (ASR) for Detection of Leukemia-Associated Translocations. AMP Abstracts. J Molecular Diagnostics 10:583, Nov. (http://jmd.amipathol.org)


    Jacobs CL, Lagoo AS, Dash RC, Raji A, Evens AM, Winter JN, Gordon LI, Kahl BS, Czader M, Srivastava G, Mann KP, Gill J, Rizzieri D, Dave S. 2008. MicroRNAs Distinguish Burkitt Lymphoma from the Molecular Subsets of Diffuse Large B Cell Lymphoma. ASH Abstracts. Blood 112:1151, Nov. (www.bloodjournal.org)


    Cole JM, Sinha R, Flowers C, Mann K. 2008. Clinical Laboratory Validation of InVivoScribe LymphotrakTM IgH TrackTwoTM Assays for the Detection of Minimal Residual Disease in CLL/SLL. AMP Abstracts. J Molecular Diagnostics 10:584, Nov. (http://jmd.amipathol.org)


    Djalilvand A, Hill CE, Mann KP. 2005. Comparison of Analysis Methods for Identification of T Cell Clonality Using PCR with Capillary Electrophoresis. Modern Path 18:227a


    Kost CB, Holden JT, Mann KP. 2005. Marginal Zone Lymphoma: A Retrospective Immunophenotypic Analysis Modern Path 18:238a.


    Halkos ME, Miller JI, Mann KP, Miller DL, Gal AA. 2003. Thoracic presentations of post-transplant lymphoproliferative disorders. Chest (Submitted).


    Wadleigh M, Niedzwiecki D, Davis P, Payne N, Sen F, Mann KP, Proia A, Hollis D, Rizzieri DA. 2001. Increased microvessel density in non-Hodgkin's lymphoma (NHL) is localized to the site of disease changes in accordance with disease response. Blood 98:4669.


    Rizzieri DA, Wikstrand CJ, Mann KP, Sen F, Proia AD, Niedzwiecki D, Bigner DD, Vredenburgh J. 1999. Markers of angiogenesis, factor VIII and tenascin, correlate with disease activity in patients with non-Hodgkin's lymphoma. Blood 94:4339.


    Smith C, Lilly S, Mann KP, Livingston E, Myers S, Lyerly HK, Miralles GD. 1998. AIDS-related malignancies [Review]. Annals of Medicine 30:323-344.


    Liu K, Liu J, Mann KP, McLendon R, Traweek ST. 1997. B-cell clonality in Castleman's disease, plasma cell type. Lab Invest 76:752.


    Mann KP, Fong AM, Patel DD. 1996. Expression of CD6 and its ligand, ALCAM, on hematopoietic malignancies of the myeloid and B-cell lineages. Tissue Antigens 48:AS403.


    Mann KP, Fong AM, Patel DD. 1996. Expression of CD6 and CD6L(ALCAM) in hematopoietic neoplasms. Cytometry 26:343.


    Mann KP, Fong AM, Patel DD. 1996. Expression of CD6 and CD6L(ALCAM) in hematopoietic neoplasms. Cytometry 26:343.


    McLendon RE, Friedman AH, Provenzale JM, Brown MT, Mann KP. 1996. Castleman's disease (plasma cell variant) confined to the leptomeninges. J Neuropathol Exp Neurol 55: 76.


    Mann KP, Liu J, DeCastro CM, Moore JO, Bigner S, Traweek ST. 1995. CD56 (N-CAM) expression in acute non-lymphoid leukemia (ANLL) and Myelodysplastic syndrome (MDS). Mod Pathol 9:116a.


    Rizzieri DA, DeCastro CM, Mann KP, Moore JO. 1995. T cell lymphoblastic leukemia with mediastinal mass and c-kit expression. Blood 86(suppl 1):777a.


    DeCastro CM, Moore JO, Traweek T, Mann KP. 1995. Bone marrow necrosis secondary to hydroxyurea treatment for the retinoic acid syndrome. Blood 86(suppl 1): 755a.


    Mann KP, Hall B, Kamino H, Borowitz MJ, Ratech H. 1994. Neutrophil rich Ki-1positive anaplastic large cell malignant lymphoma. Mod Pathol 7:114a.


    Mann KP, Weiss EA, Nevins JR. 1991. Role of polyadenylation factors, particularly the downstream specific factor, in selective poly(A) site utilization. Presented at Cold Spring Harbor Laboratories meeting on RNA Processing.


    Mann KP. 1986. The identification and characterization of an Epstein-Barr virus protein found in the plasma membrane of latently infected cells. Ph.D. Dissertation. Sackler School of Graduate Biomedical Sciences, Tufts University.