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    Experimental Pathology
    105J Whitehead Bldg., 615 Michael Street
    Atlanta, GA 30322
    404 712-2809 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Carlos Sanchez Moreno, PhD

    Cancer Biology
    Bioinformatics

    Associate Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Associate Professor, Department of Biomedical Informatics

    Member, Winship Cancer Institute


    Pathology Division(s):
    Experimental Pathology


    Email Address:
    cmoreno@emory.edu


    Education:

    B.S.   Aeronautics and Astronautics, Massachusetts Institute of Technology, 1982 - 1986

    M.S.   Aeronautics and Astronautics, Massachusetts Institute of Technology, 1986 - 1988

    Ph.D.   Genetics and Molecular Biology, Emory University, 1992 - 1998



    Research Interests:

    - Translational Cancer Genomics
    My main research interests are in translational cancer bioinformatics and systems biology, to identify diagnostic markers for more effective and personalized therapies, to identify new potential therapeutic targets, and to better understand the biology of tumor progression. My research has focused on the dissection of the perturbed transcriptional networks in prostate, brain, breast, and ovarian cancers using DNA microarrays and next generation sequencing. My lab has identified several genes that are strongly correlated with prostate cancer progression, including two developmental transcription factors, HOXC6 and SOX4. We are also developing mRNA and microRNA biomarkers of recurrence in prostate cancer. My lab analyzes genome-wide expression profiles, transcriptional networks, ChIP-chip and ChIP-seq studies, biological pathways, and evolutionarily conserved transcription factor binding sites to dissect cancer-related transcriptional networks and identify new drug targets and biomarkers.


    - Cancer Biomarkers
    We are developing new biomarkers for management of prostate cancer


    - Cancer Target Discovery and Development
    We are developing tools for analysis of protein-protein interactions in cancer cells for identification and prioritization of novel drug targets.



    Honors / Awards:

    NCI Center to Reduce Cancer Health Disparities (CRCHD) Mentorship Award, 2017

    John Kauffman Prostate Cancer Research Award, 2015

    DOD CDMRP Prostate Cancer IDEA Development Award, 2010-2012

    NIH 2R01 CA106826 - Developmental Transcription Factors in Prostate Cancer, 2009-2014

    ASIP Cotran Established Investigator Award, 2009

    K22 Career Transition Award, 2002 - 2005

    NIH Minority Supplement for Postdoctoral Training (MIPT), 1998 - 2001

    NRSA F31 Predoctoral Fellowship for Minority Students, 1993 - 1998

    Selected Publications:

    Published and Accepted Research Articles -

    2017. McMillan, C Li, V Gonzalez-Pecchi, X Dong, X Mo, S Liu, B Revennaugh, W Zhou, AI Marcus, S Harati, X Chen, MA Johns, M White, CS Moreno, LAD Cooper, Y Du, FR Khuri, H Fu. The OncoPPi Network of Cancer-focused Protein-Protein Interactions to Inform Biological Insights and Therapeutic Strategies. Nature Communications. 8:14356. doi:10.1038/ncomms14356


    2017. S Harati, LAD Cooper, JD Moran, Y Du, AA Ivanov, MA Johns, FR Khuri, H Fu, CS Moreno, MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development, PLoS ONE, 12:e0170339.


    2017. KL Pellegrini, MG Sanda, D Patil, Q Long, N Erho, M Takhar, K Yousefi, M Santiago-Jimenez, E Davicioni, EA Klein, RB Jenkins, RJ Karnes, CS Moreno, Evaluation of a 24-Gene Signature for Prognosis of Metastatic Events and Prostate Cancer-Specific Mortality, British Journal of Urology. doi: 10.1111/bju.13779.


    2017. B Bilir, NV Sharma, J Lee, B Hammarstrom, A Svindland, O Kucuk, and CS Moreno, Effects of Genistein Supplementation on Genome-wide DNA Methylation and Gene Expression in Patients with Localized Prostate Cancer, International Journal of Oncology, 51: 223-234.


    2016. B Bilir, AO Osunkoya, WG Wiles IV, S Sannigrahi, V Lefebvre, D Metzger, DD Spyropoulos, WD Martin, and CS Moreno, SOX4 is essential for prostate tumorigenesis initiated by PTEN ablation. Cancer Research, 2016; 76(5):1112-21.


    2015. KL Pellegrini, MG Sanda, and CS Moreno, RNA Biomarkers to Facilitate the Identification of Aggressive Prostate Cancer, Molecular Aspects of Medicine. 2015; 45:37-46.


    2015. F Lian, N Sharma, JD Moran, and CS Moreno, The Biology of Castration Resistant Prostate Cancer, Current Problems in Cancer, 39(1):17-28


    2014. WG Wiles IV, Z Mou, Y Du, CD Scharer, DD Spyropoulos, N Jenkins, N Copeland, WD Martin, and CS Moreno, Mutation of Murine Sox4 Untranslated Regions Results in Female-specific Embryonic Lethality, In Vivo, 28(5):709-718.


    2014. Q Long, J Xu, AO Osunkoya, S Sannigrahi, BA Johnson, W Zhou, T Gillespie, JY Park, RK Nam, L Sugar, A Stanimirovic, AK Seth, JA Petros, and CS Moreno, Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence, Cancer Research, 74(12):3228-37.


    2013. B Bilir, O Kucuk, and CS Moreno, Wnt pathway blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells, Journal of Translational Medicine, 11:280.


    2012. CJ Phillip, CK Giardina, B Bilir, DJ Cutler, YH Lai, O Kucuk and CS Moreno, Genistein Cooperates with the Histone Deacetylase Inhibitor Vorinostat to Induce Cell Death in Prostate Cancer Cells, BMC Cancer, 12:145.


    2011. A Gordanpour, A Stanimirovic, RK Nam, CS Moreno, C Sherman, L Sugar, and A Seth, miR-221 is Down-regulated in TMPRSS2:ERG Fusion-positive Prostate Cancer, Anticancer Research, 31(2):403-10.


    2011. L Qi, AC Bellail, MR Rossi, Z Zhang, H Pang, S Hunter, C Cohen, CS Moreno, JJ Olson, S Li, C Hao, Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis. Apoptosis, August 30, Epub ahead of print.


    2011. Q Long, BA Johnson, AO Osunkoya, Y-H Lai, W Zhou, M Abramovitz, M Xia, M Bouzyk, R Nam, L Sugar, A Stanimirovic, BR Leyland-Jones, AK Seth, JA Petros, CS Moreno, Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy, American Journal of Pathology, 179(1):46-54.


    2011. Y-H Lai, J Cheng, D Cheng, ME Feasel, KD Beste, J Peng, A Nusrat and CS Moreno, SOX4 interacts with Plakoglobin in a Wnt3a-dependent manner in prostate cancer cells BMC Cell Biology, 12:50.


    2010. BG Barwick, M Abramovitz, M Bouzyk, M Ordanic-Kodani, CS Moreno, R Nam, W Tang, A Seth, BR Leyland-Jones, Prostate cancer genes associated with TMPRSS2-ERG gene fusion and prognostic of biochemical recurrence in multiple cohorts, British Journal of Cancer, 102(3):570-6.


    2010. MW Coolen, C Stirzaker, JZ Song, AL Statham, Z Kassir, CS Moreno, AN Young, V Varma, TP Speed, M Cowley, P Lacaze, W Kaplan, MD Robinson, and SJ Clark. Consolidation of the cancer genome into domains of repressive chromatin by long range epigenetic silencing (LRES), Nature Cell Biology, 12(3):235-46.


    2010. LA Cooper, DA Gutman, Q Long, BA Johnson, SR Cholleti, T Kurc, JH Saltz, DJ Brat, CS Moreno, The Proneural Molecular Signature is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas, PLoS One, Sep 3;5(9). pii: e12548.


    2010. LA Cooper, J Kong, DA Gutman , F Wang, SR Cholleti, TC Pan, PM Widener, A Sharma, T Mikkelsen, AE Flanders, DL Rubin, EG Van Meir, TM Kurc, CS Moreno, DJ Brat, JH Saltz, An Integrative Approach For In Silico Glioma Research, IEEE Trans Biomed Eng. Oct;57(10):2617-21.


    2010. CS Moreno, The SOX4 and HOXC6 Transcriptional Networks in Prostate Cancer Progression: Crosstalk with the Wnt, Notch, and PI3K Pathways, American Journal of Pathology, 176(2):518-27.


    2009. CD Scharer, CD McCabe, M Ali-Seyed, MF Berger, ML Bulyk, and CS Moreno. Genome-wide Promoter Analysis of the SOX4 Transcriptional Network in Prostate Cancer Cells. Cancer Research, 69(2):709-717.


    2009. T Narita, S Yin, CF Gelin, CS Moreno, KC Nicolaou, and EG Van Meir. Identification of a novel small molecule HIF-1± translation inhibitor, Clinical Cancer Research, 15(19):6128-36.


    2008. JS Rao, S Karanam, CD McCabe, and CS Moreno, Genomic Promoter Analysis Predicts Functional Transcription Factor Binding, Advances in Bioinformatics, vol. 2008, Article ID 369830, doi:10.1155/2008/369830.


    2008. CO Evans, CS Moreno, X Zhan, M McCabe, PM Vertino, DM Desiderio, and NM Oyesiku. Molecular Signaling in Human Prolactin-Secreting Adenomas Identified by Gene Expression Profiling, RT-qPCR, and Proteomic Analyses, Pituitary, 11(3): 231-45.


    2008. CD McCabe, DD Spyropoulos, WD Martin, and CS Moreno. Genome-wide Analysis of the Homeobox C6 Transcriptional Network in Prostate Cancer, Cancer Research, 68(6):1988-96.


    2008. M. Abramovitz, M. Ordanic-Kodani, Y. Wang, Z. Li, C. Catzavelos, M. Bouzyk, G. W. Sledge Jr, C.S. Moreno*, and B. Leyland-Jones. Optimization of RNA extraction from FFPE tissues for expression profiling in the DASL assay. Biotechniques, 44:417-423. * corresponding author.


    2008. L Guo, D Zhong, S Lau, X Liu, X Dong, X Sun, P Liu, VW Yang, PM Vertino, CS Moreno, V Varma, J Dong, and W Zhou. SOX7 as an Independent Checkpoint for ²-Catenin Function in Prostate and Colon Epithelial Cells, Molecular Cancer Research, 6(9): 1421-1430.


    2008. CD Scharer, N Laycock, AO Osunkoya, S Logani, JF McDonald, BB Benigno, and CS Moreno. Aurora Kinase Inhibitors Synergize with Paclitaxel to Induce Apoptosis in Ovarian Cancer Cells. Journal of Translational Medicine, 6:79.


    2007. C.S. Moreno, L. Matyunina, E. Dickerson, N. Schubert, N.J. Bowen, S. Logani, B.B. Benigno and J.F. McDonald, Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas, PLoS ONE, 2(5): e441.


    2007. DL Jaye, N Fujita, CM Geigerman, RE Fuller, S Li, S Hunter, P Taysavang, CS Moreno, and PA Wade. The BCL-6-associated transcriptional corepressor, MTA3, is selectively expressed in germinal center B cells and lymphomas of putative germinal center derivation, The Journal of Pathology, Jun 15, 213(1):106-15.


    2006. P. Liu, S. Ramachandran, M. Ali-Seyed, C.D. Scharer, N. Laycock, W. B. Dalton, H. Williams, S. Karanam, M. W. Datta, D. L. Jaye, and C. S. Moreno. SOX4 is a Transforming Oncogene in Human Prostate Cancer Cells. Cancer Research, 66(8):4011-4018.


    2006. Ali-Seyed M, Laycock N, Karanam S, Xiao W, Blair ET, and C. S. Moreno. Cross-Platform Expression Profiling Demonstrates that SV40 Small Tumor Antigen Activates Notch, Hedgehog, and Wnt Signaling in Human Cells. BMC Cancer, 6:54.


    2005. C. S. Moreno, C-O. Evans, X. Zhan M. Okor, D.M. Desiderio, N.M. Oyesiku. Novel Molecular Signaling in Human Clinically Non-functional Pituitary Adenomas Identified by Gene Expression Profiling and Proteomic Analyses, Cancer Research, 65(22):10214-22.


    2005. A. Schuetz, M. B. Amin, C. S. Moreno, Q. Yin-Goen, C. Cohen, C. D. Hornsby, J. A. Petros, M. M. Issa, J. G. Pattaras, K. Ogan, F. F. Marshall and A. N. Young. Molecular Classification of Renal Tumors by Gene Expression Profiling. Journal of Molecular Diagnostics, 7(2):206-18.


    2005. S. Ramachandran, P. Liu, A. N. Young, Q. Yin-Goen, S. D. Lim, N. Laycock, M. B. Amin, J. K. Carney, F. F. Marshall, J. A. Petros and C. S. Moreno. Loss of HOXC6 Expression Induces Apoptosis in Prostate Cancer Cells. Oncogene, 24(1): 188-198.


    2004. Karanam, S, and CS Moreno. CONFAC: Automated Application of Comparative Genomic Promoter Analysis to DNA Microarray Datasets. Nucleic Acids Research, Jul 1;32(Web Server issue):W475-84.


    2004. Moreno, CS, S Ramachandran, D Ashby, N Laycock, CA Plattner, W Chen, WC Hahn, and DC Pallas. Signaling and Transcriptional Changes Critical for Transformation of Human Cells by SV40 Small Tumor Antigen or PP2A B56¿ Knockdown, Cancer Research, 64(19):6978-6988.


    2003. Fujita N, Jaye, DL, Kajita M, Geigerman C, Moreno CS, and Wade PA, MTA3, an Mi-2/NuRD Complex Subunit, Regulates an Invasive Growth Pathway in Breast Cancer, Cell 113(2): 207-19.


    2002. Hunter SB and Moreno CS, Expression Microarray Analysis Of Brain Tumors: What Have We Learned So Far (Review), Frontiers in Bioscience 7: c74-82.


    2001. Wei H, Ashby DG, Moreno CS, Ogris E, Yeong FM, Corbett AH, Pallas DC, Carboxymethylation of the PP2A Catalytic Subunit in Saccharomyces cerevisiae Is Required for Efficient Interaction with the B-type Subunits Cdc55p and Rts1p, Journal of Biological Chemistry 276(2):1570-1577.


    2001. Yu XX *, Du X *, Moreno CS *, Green RE, Ogris E, Feng Q, Chou L, McQuoid MJ, and Pallas DC, Methylation of the Protein Phosphatase 2A Catalytic Subunit is Essential for Association of B¿ Regulatory Subunit but not SG2NA, Striatin, or Polyomavirus Middle Tumor Antigen, Molecular Biology of the Cell, 12(1):185-199. *Equal contribution.


    2001. Young AN, Amin MB, Moreno CS, Lim SD, Cohen C, Petros JA, Marshall FF, and Neish AS, Expression Profiling of Renal Epithelial Neoplasms: A Method for Tumor Classification and Discovery of Diagnostic Molecular Markers, The American Journal of Pathology 158(5):1639-51.


    2001. Moreno CS, Lane WS, and Pallas DC, A Mammalian Homolog Of Yeast MOB1 Is Both A Member And A Putative Substrate Of Striatin-Family/Protein Phosphatase 2A Complexes, Journal of Biological Chemistry 276(26): 24253-24260.


    2000. Moreno, CS, S Park, K Nelson, DG Ashby, F Hubalek, WS Lane, and DC Pallas, The WD40 Repeat Proteins Striatin and SG2NA are Members of a Novel Family of Calmodulin-Binding Proteins that Associate with PP2A, Journal of Biological Chemistry, 275(8): 5257-5263.


    1999. Moreno, CS, GW Beresford, PL Plence, AC Morris, and JM Boss, CREB Regulates MHC Class II Expression in a CIITA-dependent manner, Immunity, 10 (2):143-151.


    1997. Moreno, CS, EM Rogers, JA Brown, and JM Boss, Regulatory Factor X, a Bare Lymphocyte Syndrome Transcription Factor, is a Multimeric Phosphoprotein Complex, Journal of Immunology, 158: 5841-5848.


    1997. Plence, PL, CS Moreno, and JM Boss, Formation of a Regulator Factor X/X2 Box-Binding Protein/Nuclear Factor Y Multiprotein Complex on the Conserved Regulatory Regions of HLA-Class II Genes, Journal of Immunology, 159: 3899-3909.


    1995. Moreno, CS, P Emery, JE West, B Durand, W Reith, B Mach, and JM Boss, Purified X2 Binding Protein (X2BP) Cooperatively Binds the Class II MHC X Box Region in the Presence of Purified RFX, the X Box Factor Deficient in the Bare Lymphocyte Syndrome, Journal of Immunology, 155: 4313-432.


    1994. Chin, K-C, C Mao, C Skinner, JL Riley, KL Wright, CS Moreno, GR Stark, JM Boss, and JP-Y Ting, Molecular Analysis of G1B and G3A IFN¿ Mutants Reveals that Defects in CIITA or RFX Result in Defective Class II MHC and Ii Gene Induction, Immunity, 1: 687-697.


    Other Publications -

    2009. CS Moreno and M Bouzyk, The Emory Biomarker Service Center, Institutional Profile, Biomarkers in Medicine, 3(5): 567-571.