Carlos Sanchez Moreno, PhD

Cancer Biology
Bioinformatics

Assistant Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

Assistant Professor, Department of Hematology and Oncology, Winship Cancer Institute

Co-Director, Winship Cancer Institute Microarray Core Facility

Pathology Division(s):
Experimental Pathology

Email Address:
cmoreno@emory.edu

Education:

B.S.   Aeronautics and Astronautics, Massachusetts Institute of Technology, 1982 - 1986

M.S.   Aeronautics and Astronautics, Massachusetts Institute of Technology, 1986 - 1988

Ph.D.   Genetics and Molecular Biology, Emory University, 1992 - 1998

Research Interests:

- Bioinformatics tools for identification of important cis-regulatory DNA elements
My laboratory is using DNA microarrays to identify novel targets for cancer therapies and developing bioinformatics tools to integrate microarray and genomic data to enable identification of important cis-regulatory DNA elements. We are analyzing expression patterns from both in vitro and in vivo mouse models to attempt to understand the changes in gene expression that are essential for tumor formation. Our analyses of human prostate carcinomas have identified developmental transcription factors that are highly correlated with Gleason score (or tumor grade) and may confer a stem-cell like phenotype to prostate cancer cells. We are focusing on identifying the downstream targets of these transcription factors, the developmental pathways that they are affecting, and why these factors are overexpressed in cancers. We are also investigating their potential as therapeutic targets using in vivo small-interfering RNA (siRNA) approaches. Finally, we are using our bioinformatics tools to analyze the regulatory elements of all human genes with the ultimate goal of building comprehensive models of gene networks in mammalian cells and understanding how those networks are disrupted in cancers.

Honors / Awards:

K22 Career Transition Award, 2002 - 2005

NIH Minority Supplement for Postdoctoral Training (MIPT), 1998 - 2001

NRSA F31 Predoctoral Fellowship for Minority Students, 1993 - 1998

Selected Publications:

Published and Accepted Research Articles -

2006. P. Liu, S. Ramachandran, M. Ali-Seyed, C.D. Scharer, N. Laycock, W. B. Dalton, H. Williams, S. Karanam, M. W. Datta, D. L. Jaye, and C. S. Moreno. SOX4 is a Transforming Oncogene in Human Prostate Cancer Cells. Cancer Research, 66(8):4011-4018.

2006. Ali-Seyed M, Laycock N, Karanam S, Xiao W, Blair ET, and C. S. Moreno. Cross-Platform Expression Profiling Demonstrates that SV40 Small Tumor Antigen Activates Notch, Hedgehog, and Wnt Signaling in Human Cells. BMC Cancer, 6:54.

2005. S. Ramachandran, P. Liu, A. N. Young, Q. Yin-Goen, S. D. Lim, N. Laycock, M. B. Amin, J. K. Carney, F. F. Marshall, J. A. Petros and C. S. Moreno. Loss of HOXC6 Expression Induces Apoptosis in Prostate Cancer Cells. Oncogene, 24(1): 188-198.

2005. A. Schuetz, M. B. Amin, C. S. Moreno, Q. Yin-Goen, C. Cohen, C. D. Hornsby, J. A. Petros, M. M. Issa, J. G. Pattaras, K. Ogan, F. F. Marshall and A. N. Young. Molecular Classification of Renal Tumors by Gene Expression Profiling. Journal of Molecular Diagnostics, 7(2):206-18.

2005. C. S. Moreno, C-O. Evans, X. Zhan M. Okor, D.M. Desiderio, N.M. Oyesiku. Novel Molecular Signaling in Human Clinically Non-functional Pituitary Adenomas Identified by Gene Expression Profiling and Proteomic Analyses, Cancer Research, 65(22):10214-22.

2004. Karanam, S, and CS Moreno. CONFAC: Automated Application of Comparative Genomic Promoter Analysis to DNA Microarray Datasets. Nucleic Acids Research, Jul 1;32(Web Server issue):W475-84.

2004. Moreno, CS, S Ramachandran, D Ashby, N Laycock, CA Plattner, W Chen, WC Hahn, and DC Pallas. Signaling and Transcriptional Changes Critical for Transformation of Human Cells by SV40 Small Tumor Antigen or PP2A B56¿ Knockdown, Cancer Research, 64(19):6978-6988.

2003. Fujita N, Jaye, DL, Kajita M, Geigerman C, Moreno CS, and Wade PA, MTA3, an Mi-2/NuRD Complex Subunit, Regulates an Invasive Growth Pathway in Breast Cancer, Cell 113(2): 207-19.

2002. Hunter SB and Moreno CS, Expression Microarray Analysis Of Brain Tumors: What Have We Learned So Far (Review), Frontiers in Bioscience 7: c74-82.

2001. Wei H, Ashby DG, Moreno CS, Ogris E, Yeong FM, Corbett AH, Pallas DC, Carboxymethylation of the PP2A Catalytic Subunit in Saccharomyces cerevisiae Is Required for Efficient Interaction with the B-type Subunits Cdc55p and Rts1p, Journal of Biological Chemistry 276(2):1570-1577.

2001. Young AN, Amin MB, Moreno CS, Lim SD, Cohen C, Petros JA, Marshall FF, and Neish AS, Expression Profiling of Renal Epithelial Neoplasms: A Method for Tumor Classification and Discovery of Diagnostic Molecular Markers, The American Journal of Pathology 158(5):1639-51.

2001. Moreno CS, Lane WS, and Pallas DC, A Mammalian Homolog Of Yeast MOB1 Is Both A Member And A Putative Substrate Of Striatin-Family/Protein Phosphatase 2A Complexes, Journal of Biological Chemistry 276(26): 24253-24260.

2001. Yu XX *, Du X *, Moreno CS *, Green RE, Ogris E, Feng Q, Chou L, McQuoid MJ, and Pallas DC, Methylation of the Protein Phosphatase 2A Catalytic Subunit is Essential for Association of B¿ Regulatory Subunit but not SG2NA, Striatin, or Polyomavirus Middle Tumor Antigen, Molecular Biology of the Cell, 12(1):185-199. *Equal contribution.

2000. Moreno, CS, S Park, K Nelson, DG Ashby, F Hubalek, WS Lane, and DC Pallas, The WD40 Repeat Proteins Striatin and SG2NA are Members of a Novel Family of Calmodulin-Binding Proteins that Associate with PP2A, Journal of Biological Chemistry, 275(8): 5257-5263.

1999. Moreno, CS, GW Beresford, PL Plence, AC Morris, and JM Boss, CREB Regulates MHC Class II Expression in a CIITA-dependent manner, Immunity, 10 (2):143-151.

1997. Moreno, CS, EM Rogers, JA Brown, and JM Boss, Regulatory Factor X, a Bare Lymphocyte Syndrome Transcription Factor, is a Multimeric Phosphoprotein Complex, Journal of Immunology, 158: 5841-5848.

1997. Plence, PL, CS Moreno, and JM Boss, Formation of a Regulator Factor X/X2 Box-Binding Protein/Nuclear Factor Y Multiprotein Complex on the Conserved Regulatory Regions of HLA-Class II Genes, Journal of Immunology, 159: 3899-3909.

1995. Moreno, CS, P Emery, JE West, B Durand, W Reith, B Mach, and JM Boss, Purified X2 Binding Protein (X2BP) Cooperatively Binds the Class II MHC X Box Region in the Presence of Purified RFX, the X Box Factor Deficient in the Bare Lymphocyte Syndrome, Journal of Immunology, 155: 4313-432.

1994. Chin, K-C, C Mao, C Skinner, JL Riley, KL Wright, CS Moreno, GR Stark, JM Boss, and JP-Y Ting, Molecular Analysis of G1B and G3A IFN¿ Mutants Reveals that Defects in CIITA or RFX Result in Defective Class II MHC and Ii Gene Induction, Immunity, 1: 687-697.