Pathology Faculty Member

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    Experimental Pathology
    105J Whitehead Bldg., 615 Michael Street
    Atlanta, GA 30322
    404 712-2809 Phone

    For an expert Pathology consultation,
    or to send a specimen, call:

    1-404-712-5947


    Carlos Sanchez Moreno, PhD

    Cancer Biology
    Bioinformatics

    Associate Professor
    Pathology & Laboratory Medicine


    Pathology Faculty Photo

    Other Appointments/Positions

    Member, Center for Comprehensive Informatics

    Member, Winship Cancer Institute

    Associate Professor, Department of Biomedical Informatics

    Scientific Director, Cancer Genomics Shared Resource

    Lead Investigator for Genomic Analysis, In Silico Brain Tumor Research Center


    Pathology Division(s):
    Experimental Pathology


    Email Address:
    cmoreno@emory.edu


    Education:

    B.S.   Aeronautics and Astronautics, Massachusetts Institute of Technology, 1982 - 1986

    M.S.   Aeronautics and Astronautics, Massachusetts Institute of Technology, 1986 - 1988

    Ph.D.   Genetics and Molecular Biology, Emory University, 1992 - 1998



    Research Interests:

    - Bioinformatics tools for identification of important cis-regulatory DNA elements
    My laboratory is using DNA microarrays to identify novel targets for cancer therapies and developing bioinformatics tools to integrate microarray and genomic data to enable identification of important cis-regulatory DNA elements. We are analyzing expression patterns from both in vitro and in vivo mouse models to attempt to understand the changes in gene expression that are essential for tumor formation. Our analyses of human prostate carcinomas have identified developmental transcription factors that are highly correlated with Gleason score (or tumor grade) and may confer a stem-cell like phenotype to prostate cancer cells. We are focusing on identifying the downstream targets of these transcription factors, the developmental pathways that they are affecting, and why these factors are overexpressed in cancers. We are also investigating their potential as therapeutic targets using in vivo small-interfering RNA (siRNA) approaches. Finally, we are using our bioinformatics tools to analyze the regulatory elements of all human genes with the ultimate goal of building comprehensive models of gene networks in mammalian cells and understanding how those networks are disrupted in cancers.



    Honors / Awards:

    DOD CDMRP Prostate Cancer IDEA Development Award, 2010-2012

    NIH 2R01 CA106826 - Developmental Transcription Factors in Prostate Cancer, 2009-2014

    ASIP Cotran Established Investigator Award, 2009

    K22 Career Transition Award, 2002 - 2005

    NIH Minority Supplement for Postdoctoral Training (MIPT), 1998 - 2001

    NRSA F31 Predoctoral Fellowship for Minority Students, 1993 - 1998

    Selected Publications:

    Published and Accepted Research Articles -

    2011. Q Long, BA Johnson, AO Osunkoya, Y-H Lai, W Zhou, M Abramovitz, M Xia, M Bouzyk, R Nam, L Sugar, A Stanimirovic, BR Leyland-Jones, AK Seth, JA Petros, CS Moreno, Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy, American Journal of Pathology, 179(1):46-54.


    2011. L Qi, AC Bellail, MR Rossi, Z Zhang, H Pang, S Hunter, C Cohen, CS Moreno, JJ Olson, S Li, C Hao, Heterogeneity of primary glioblastoma cells in the expression of caspase-8 and the response to TRAIL-induced apoptosis. Apoptosis, August 30, Epub ahead of print.


    2011. A Gordanpour, A Stanimirovic, RK Nam, CS Moreno, C Sherman, L Sugar, and A Seth, miR-221 is Down-regulated in TMPRSS2:ERG Fusion-positive Prostate Cancer, Anticancer Research, 31(2):403-10.


    2010. MW Coolen, C Stirzaker, JZ Song, AL Statham, Z Kassir, CS Moreno, AN Young, V Varma, TP Speed, M Cowley, P Lacaze, W Kaplan, MD Robinson, and SJ Clark. Consolidation of the cancer genome into domains of repressive chromatin by long range epigenetic silencing (LRES), Nature Cell Biology, 12(3):235-46.


    2010. CS Moreno, The SOX4 and HOXC6 Transcriptional Networks in Prostate Cancer Progression: Crosstalk with the Wnt, Notch, and PI3K Pathways, American Journal of Pathology, 176(2):518-27.


    2010. BG Barwick, M Abramovitz, M Bouzyk, M Ordanic-Kodani, CS Moreno, R Nam, W Tang, A Seth, BR Leyland-Jones, Prostate cancer genes associated with TMPRSS2-ERG gene fusion and prognostic of biochemical recurrence in multiple cohorts, British Journal of Cancer, 102(3):570-6.


    2010. LA Cooper, J Kong, DA Gutman , F Wang, SR Cholleti, TC Pan, PM Widener, A Sharma, T Mikkelsen, AE Flanders, DL Rubin, EG Van Meir, TM Kurc, CS Moreno, DJ Brat, JH Saltz, An Integrative Approach For In Silico Glioma Research, IEEE Trans Biomed Eng. Oct;57(10):2617-21.


    2010. LA Cooper, DA Gutman, Q Long, BA Johnson, SR Cholleti, T Kurc, JH Saltz, DJ Brat, CS Moreno, The Proneural Molecular Signature is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas, PLoS One, Sep 3;5(9). pii: e12548.


    2009. CD Scharer, CD McCabe, M Ali-Seyed, MF Berger, ML Bulyk, and CS Moreno. Genome-wide Promoter Analysis of the SOX4 Transcriptional Network in Prostate Cancer Cells. Cancer Research, 69(2):709-717.


    2009. T Narita, S Yin, CF Gelin, CS Moreno, KC Nicolaou, and EG Van Meir. Identification of a novel small molecule HIF-1± translation inhibitor, Clinical Cancer Research, 15(19):6128-36.


    2008. M. Abramovitz, M. Ordanic-Kodani, Y. Wang, Z. Li, C. Catzavelos, M. Bouzyk, G. W. Sledge Jr, C.S. Moreno*, and B. Leyland-Jones. Optimization of RNA extraction from FFPE tissues for expression profiling in the DASL assay. Biotechniques, 44:417-423. * corresponding author.


    2008. CO Evans, CS Moreno, X Zhan, M McCabe, PM Vertino, DM Desiderio, and NM Oyesiku. Molecular Signaling in Human Prolactin-Secreting Adenomas Identified by Gene Expression Profiling, RT-qPCR, and Proteomic Analyses, Pituitary, 11(3): 231-45.


    2008. JS Rao, S Karanam, CD McCabe, and CS Moreno, Genomic Promoter Analysis Predicts Functional Transcription Factor Binding, Advances in Bioinformatics, vol. 2008, Article ID 369830, doi:10.1155/2008/369830.


    2008. CD Scharer, N Laycock, AO Osunkoya, S Logani, JF McDonald, BB Benigno, and CS Moreno. Aurora Kinase Inhibitors Synergize with Paclitaxel to Induce Apoptosis in Ovarian Cancer Cells. Journal of Translational Medicine, 6:79.


    2008. CD McCabe, DD Spyropoulos, WD Martin, and CS Moreno. Genome-wide Analysis of the Homeobox C6 Transcriptional Network in Prostate Cancer, Cancer Research, 68(6):1988-96.


    2008. L Guo, D Zhong, S Lau, X Liu, X Dong, X Sun, P Liu, VW Yang, PM Vertino, CS Moreno, V Varma, J Dong, and W Zhou. SOX7 as an Independent Checkpoint for ²-Catenin Function in Prostate and Colon Epithelial Cells, Molecular Cancer Research, 6(9): 1421-1430.


    2007. DL Jaye, N Fujita, CM Geigerman, RE Fuller, S Li, S Hunter, P Taysavang, CS Moreno, and PA Wade. The BCL-6-associated transcriptional corepressor, MTA3, is selectively expressed in germinal center B cells and lymphomas of putative germinal center derivation, The Journal of Pathology, Jun 15, 213(1):106-15.


    2007. C.S. Moreno, L. Matyunina, E. Dickerson, N. Schubert, N.J. Bowen, S. Logani, B.B. Benigno and J.F. McDonald, Evidence that p53-mediated cell-cycle-arrest inhibits chemotherapeutic treatment of ovarian carcinomas, PLoS ONE, 2(5): e441.


    2006. P. Liu, S. Ramachandran, M. Ali-Seyed, C.D. Scharer, N. Laycock, W. B. Dalton, H. Williams, S. Karanam, M. W. Datta, D. L. Jaye, and C. S. Moreno. SOX4 is a Transforming Oncogene in Human Prostate Cancer Cells. Cancer Research, 66(8):4011-4018.


    2006. Ali-Seyed M, Laycock N, Karanam S, Xiao W, Blair ET, and C. S. Moreno. Cross-Platform Expression Profiling Demonstrates that SV40 Small Tumor Antigen Activates Notch, Hedgehog, and Wnt Signaling in Human Cells. BMC Cancer, 6:54.


    2005. C. S. Moreno, C-O. Evans, X. Zhan M. Okor, D.M. Desiderio, N.M. Oyesiku. Novel Molecular Signaling in Human Clinically Non-functional Pituitary Adenomas Identified by Gene Expression Profiling and Proteomic Analyses, Cancer Research, 65(22):10214-22.


    2005. A. Schuetz, M. B. Amin, C. S. Moreno, Q. Yin-Goen, C. Cohen, C. D. Hornsby, J. A. Petros, M. M. Issa, J. G. Pattaras, K. Ogan, F. F. Marshall and A. N. Young. Molecular Classification of Renal Tumors by Gene Expression Profiling. Journal of Molecular Diagnostics, 7(2):206-18.


    2005. S. Ramachandran, P. Liu, A. N. Young, Q. Yin-Goen, S. D. Lim, N. Laycock, M. B. Amin, J. K. Carney, F. F. Marshall, J. A. Petros and C. S. Moreno. Loss of HOXC6 Expression Induces Apoptosis in Prostate Cancer Cells. Oncogene, 24(1): 188-198.


    2004. Karanam, S, and CS Moreno. CONFAC: Automated Application of Comparative Genomic Promoter Analysis to DNA Microarray Datasets. Nucleic Acids Research, Jul 1;32(Web Server issue):W475-84.


    2004. Moreno, CS, S Ramachandran, D Ashby, N Laycock, CA Plattner, W Chen, WC Hahn, and DC Pallas. Signaling and Transcriptional Changes Critical for Transformation of Human Cells by SV40 Small Tumor Antigen or PP2A B56¿ Knockdown, Cancer Research, 64(19):6978-6988.


    2003. Fujita N, Jaye, DL, Kajita M, Geigerman C, Moreno CS, and Wade PA, MTA3, an Mi-2/NuRD Complex Subunit, Regulates an Invasive Growth Pathway in Breast Cancer, Cell 113(2): 207-19.


    2002. Hunter SB and Moreno CS, Expression Microarray Analysis Of Brain Tumors: What Have We Learned So Far (Review), Frontiers in Bioscience 7: c74-82.


    2001. Young AN, Amin MB, Moreno CS, Lim SD, Cohen C, Petros JA, Marshall FF, and Neish AS, Expression Profiling of Renal Epithelial Neoplasms: A Method for Tumor Classification and Discovery of Diagnostic Molecular Markers, The American Journal of Pathology 158(5):1639-51.


    2001. Yu XX *, Du X *, Moreno CS *, Green RE, Ogris E, Feng Q, Chou L, McQuoid MJ, and Pallas DC, Methylation of the Protein Phosphatase 2A Catalytic Subunit is Essential for Association of B¿ Regulatory Subunit but not SG2NA, Striatin, or Polyomavirus Middle Tumor Antigen, Molecular Biology of the Cell, 12(1):185-199. *Equal contribution.


    2001. Wei H, Ashby DG, Moreno CS, Ogris E, Yeong FM, Corbett AH, Pallas DC, Carboxymethylation of the PP2A Catalytic Subunit in Saccharomyces cerevisiae Is Required for Efficient Interaction with the B-type Subunits Cdc55p and Rts1p, Journal of Biological Chemistry 276(2):1570-1577.


    2001. Moreno CS, Lane WS, and Pallas DC, A Mammalian Homolog Of Yeast MOB1 Is Both A Member And A Putative Substrate Of Striatin-Family/Protein Phosphatase 2A Complexes, Journal of Biological Chemistry 276(26): 24253-24260.


    2000. Moreno, CS, S Park, K Nelson, DG Ashby, F Hubalek, WS Lane, and DC Pallas, The WD40 Repeat Proteins Striatin and SG2NA are Members of a Novel Family of Calmodulin-Binding Proteins that Associate with PP2A, Journal of Biological Chemistry, 275(8): 5257-5263.


    1999. Moreno, CS, GW Beresford, PL Plence, AC Morris, and JM Boss, CREB Regulates MHC Class II Expression in a CIITA-dependent manner, Immunity, 10 (2):143-151.


    1997. Moreno, CS, EM Rogers, JA Brown, and JM Boss, Regulatory Factor X, a Bare Lymphocyte Syndrome Transcription Factor, is a Multimeric Phosphoprotein Complex, Journal of Immunology, 158: 5841-5848.


    1997. Plence, PL, CS Moreno, and JM Boss, Formation of a Regulator Factor X/X2 Box-Binding Protein/Nuclear Factor Y Multiprotein Complex on the Conserved Regulatory Regions of HLA-Class II Genes, Journal of Immunology, 159: 3899-3909.


    1995. Moreno, CS, P Emery, JE West, B Durand, W Reith, B Mach, and JM Boss, Purified X2 Binding Protein (X2BP) Cooperatively Binds the Class II MHC X Box Region in the Presence of Purified RFX, the X Box Factor Deficient in the Bare Lymphocyte Syndrome, Journal of Immunology, 155: 4313-432.


    1994. Chin, K-C, C Mao, C Skinner, JL Riley, KL Wright, CS Moreno, GR Stark, JM Boss, and JP-Y Ting, Molecular Analysis of G1B and G3A IFN¿ Mutants Reveals that Defects in CIITA or RFX Result in Defective Class II MHC and Ii Gene Induction, Immunity, 1: 687-697.


    Other Publications -

    2009. CS Moreno and M Bouzyk, The Emory Biomarker Service Center, Institutional Profile, Biomarkers in Medicine, 3(5): 567-571.