Pathology Faculty Member

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    Experimental Pathology
    145 Whitehead Bldg., 615 Michael St.
    Atlanta, GA 30322
    404 712-2814 Phone

    For an expert Pathology consultation,
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    Keqiang Ye, PhD

    Cancer Biology

    Pathology & Laboratory Medicine

    Pathology Faculty Photo

    Other Appointments/Positions

    Professor, Pharmacology Graduate Program (MSP)

    Professor, Biochemistry and Cell & Development Graduate Program

    Pathology Division(s):
    Experimental Pathology

    Email Address:


    BS   Chemistry, Jilin University, - 1990

    MS   Chemistry, Beijing University, - 1993

    PhD   Biochemistry, Emory University, - 1998

    PostDoc   Neuroscience, Johns Hopkins University, - 2001

    Research Interests:

    - How NGF regulates neuronal cell survival in the nucleus
    To study neurotrophin signalings in neuronal cell survival and drug discovery in neuroprotection. To dissect the physiological roles of PIKE in tumorigenesis and anti-cancer drug development To determine the neuronal cell death molecular mechanisms of neuroexcitotoxicity and stroke in central nervous system and drug discovery

    Honors / Awards:

    The Sontag Foundation for Distinguished Scientist Award(2003) Nominee from Emory for the Keck Foundation (2004) American Cancer Society Scholar (2004), 2001-present

    Selected Publications:

    Published and Accepted Research Articles -

    Jee-Yin Ahn, Xia Liu, Pui-Kwang Chan, Dongmei Cheng, Junming Peng, Paul A. Wade and Keqiang Ye (2005). Nucleophosmin/B23, a Nuclear PI (3,4,5)P3 Receptor, Mediates the Anti-apoptotic Actions of NGF by Inhibiting CAD. Molecular Cell 18, 435-445.

    Yuanxin Hu, Xia Liu, Haian Fu and Keqiang Ye (2005). Akt Phosphorylates Acinus and Inhibits its Proteolytic Cleavage, Preventing Chromatin Condensation. EMBO Journal 24: 3543-3554.

    Yuanxin Hu, Zhixue Liu and Keqiang Ye (2005). Phosphoinositol Lipids Bind to PIKE GTPase and Mediate its Stimulatory Effect on PI 3-kinase and Akt Signalings. Proc. Natl. Acad. Sci. USA. 102: 16853-16858.

    Jee-Yin Ahn and Keqiang Ye (2005). PIKE GTPase Signaling and Function. Inter. J. Biol. Sci. 1, 44-51.

    Xia Liu and Keqiang Ye (2005). Src Homology Domains in Phospholipase C-1 Mediate its Anti-apoptotic Action Through Regulating the Enzymatic Activity. J. Neurochem. 93, 892-898.

    Jee-Yin Ahn, Yuanxin Hu, Todd G Kroll, Erwin G. van Meir and Keqiang Ye (2004) PIKE-A is amplified in human cancers and prevents apoptosis by upregulating Akt. Proc. Natl. Acad. Sci. USA.101 (18):6993-8.

    Jee-Yin Ahn, Rong Rong, Xuesong Liu and Keqiang Ye (2004). PIKE/nuclear PI 3-Kinase Mediates the Anti-apoptotic Actions of NGF in the Nucleus. EMBO Journal 23(20):3995-4006.

    Rong Rong, Ezequiel I. Surace, Carrie A. Haipek, David H. Gutmann and Keqiang Ye (2004). Serine 518 Phosphorylation Modulates Merlin Intramolecular Association and Binding to Critical Effectors Important for NF2 Growth Suppression. Oncogene 23, 8447-8454.

    Rong Rong, Xiaoling Tang, David H. Gutmann and Keqiang Ye (2004). The neurofibromatosis 2 (NF2) tumor suppressor, merlin, inhibits PI 3-kinase through interaction with PIKE-L. Proc. Natl. Acad. Sci. USA. 101, 18200-18205.

    Jee-Yin Ahn, Rong Rong, Todd G. Kroll, Erwin G. Van Meir, Solomon H. Snyder and Keqiang Ye (2004). PIKE-A, a Novel GTPase, is a Physiologic Regulator of Akt and Mediates Cellular Invasion. J. Biol.Chem. 279 (16):16441-51.

    Keqiang Ye and Solomon H. Snyder (2004). PIKE GTPase: a novel mediator of phosphoinositide signaling. J. Cell Science, 117, 155-161.

    Hongbo R. Luo, Yi Elaine Huang, Jianmeng C. Chen, Adolfo Saiardi, Miho Iijima, Keqiang Ye, Yunfei Huang, Eiichiro Nagata, Peter Devreotes and Solomon H. Snyder (2003). Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 Interactions. Cell, 114, 559-572.

    Rong Rong, Jee-Yin Ahn, Peng Chen and Keqiang Ye (2003). The phospholipase activity of PLC-_1 is required for NGF to activate MAP kinase pathway in PC12 cells. J Biol Chem 278, 52497-52503.

    Rong Rong, Honglian Huang, Eiichiro Nagata, Daniel Kalman, Judith A. Kapp, Jiancheng Tu, Paul F. Worley, Solomon H. Snyder and Keqiang Ye (2003). PIKE-L/Homer Complex Couples mGluR I to PI 3-kinase, Preventing Neuronal Apoptosis. Nature Neuroscience 6, 1153-1161.

    Bai X, Cerimele F, Ushio-Fukai M, Waqas M, Campbell P, Govindarajan B, Der C, Battle T, Frank DA, Ye Keqiang, Murad E, Dubiel W, Soff G, Arbiser JL (2003). Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 278, 35501-7.

    Hongbo R. Luo, Adolfo Saiardi, Hongbo Yu, Echiro Nagata, Keqiang Ye and Solomon H. Snyder (2002). Inositol Pyrophosphates are Required for DNA Hyperrecombination in Protein Kinase C1 Mutant Yeast. Biochemistry 41, 2509-2515.

    Zhou Jun, Gupta Kamlesh, Yao Joyce, Ye Keqiang, Panda Dulal, Giannakakou Paraskevi, Joshi Harish C. (2002). Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine. J Biol Chem. 277, 39777-39785.

    Keqiang Ye, Bahman Aghdassi, Hongbo R. Luo, John L. Moriarity, Frederick Y. Wu, Jenny J. Hong, K. Joseph Hurt, Sun Sik Bae, Pann-Ghill Suh, and Solomon H. Snyder (2002). PLC-_1 is a Physiological Guanine Nucleotide exchange Factor for the Nuclear GTPase PIKE. Nature, 415, 541-544.

    Keqiang Ye, Jun Zhou, Jaren Landen E. Morton Bradbury and Harish C. Joshi (2001). Sustained activation of p34cdc2 is required for noscapine-induced apoptosis. Journal of Biological Chemistry 276, 50, 46697-46700.

    Bahman Aghdassi, Keqiang Ye, Adam Rosnick, Alex Huang, Jason Ha and Solomon H. Snyder (2001). FKBP12 is Required for G1 Phase Progression. Proc. Natl. Acad. Sci. USA. 98, 2425-2430.

    Hongbo R. Luo, Adolfo Saiardi, Echiro Nagata, Keqiang Ye, Akira Sawa, and Solomon H. Snyder (2001). A Novel Protein, PINK, Interacts with Inositol Hexakisphosphate Kinase. Neuron 31, 439-451.

    Keqiang Ye, K. Joseph Hurt, Fredrick Y. Wu, Ming Fang, Hongbo R. Luo, Seth Blackshaw, Christopher D. Ferris and Solomon H. Snyder (2000). PIKE: a Nuclear GTPase That Enhances PI-3 Kinase Activity and is Regulated by Protein 4.1N. Cell 103: 919-930.

    Ming Fang, Sami Jaffery, Akira S awa, Keqiang Ye, Xiaojiang Luo and Solomon H. Snyder (2000). A Novel Nitric Oxide Signaling Pathway: Anchoring of Neuronal Nitric Oxide Synthase to Dexras1 Via Capon. Neuron 28:183-193.

    Yong Ke, Keqiang Ye, Hans E. Grossniklaus, Harish C. Joshi, and Judith A. Kapp (2000). The Opium Alkloid, Noscapine, Inhibits Tumor Growth and Prolongs Survival of Tumor-bearing Mice When Administered Orally. Cancer Immunol. Immunother. 49 (4-5): 217-25.

    Keqiang Ye, Duane A. Compton, Michael M. Lai, Loren D. Walensky and Solomon H. Snyder (1999). Protein 4.1N Binding to Nuclear NuMA in PC12 Cells Mediates the Anti-proliferative Actions of Nerve Growth Factor. Journal of Neuroscience 19 (24): 10747-10756.

    Keqiang Ye, Yong Ke, Nagalakshmi Keshava, Judith A. Kapp, Rajeshwar R. Tekmal, John Petros and Harish C. Joshi (1998). Opium Alkaloid Noscapine is Anti-Tumor Agent That Arrests Metaphase and Induces Apoptosis in Dividing Cells. Proc. Natl. Acad. Sci. USA. 95, 1601-1606.

    Keqiang Ye, Jianhua, Dong, Kunyuan Qiu and Xinde Feng (1994). Initiation Mechanism of Photo-Induced Polymerization of N-4-methylphenyl Maleimide Initiated by N,N-Dimethyl-p-Toludine. Acta Polymerica Sinica, 2, 253-256.

    Kunyuan Qiu and Keqiang Ye (1993). Polymerization and Copolymerization of N-(para-methylphenyl) Maleimide Initaited by N,N-Dimethyl-Para-Toludine under UV Light Irradiation.Acta Polymerica Sinica, 1, 125-128.

    Books Edited and Written -

    Keqiang Ye (2005). PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death. J. Cell. Biochem. Review article, 96(3) 463-472.

    Keqiang Ye (2005). PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death. J. Cell. Biochem. Review article, 96(3) 463-472.