Emory Pathology Research Lab Page: Dr. Keqiang Ye

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  • Laboratory of:

    Keqiang Ye, PhD
    Pathology & Laboratory Medicine
    Emory University School of Medicine
    Whitehead Biomedical Building
    Room 145
    615 Michael Street
    Atlanta, GA 30322, USA

    Primary Areas of Research:

    Cancer Biology
    Cardiovascular Research
    Epithelial Cell Biology
    Infectious Diseases
    Oncology/DNA Repair
    Renal Pathology
    Signal Transduction
    Transfusion Medicine

    Dr. Keqiang Ye's Lab Team

    Experimental Pathology Division - Signal Transduction

    Keqiang Ye, PhD


    ·Issued: No. 01028 "Noscapine and Noscapine Derivatives, Useful as Anticancer Agent" (60/057/037 and PCT/US98/14979)
    ·Issued: No. 02040 "Delivery Systems and Methods for Nocapine and Noscapine Derivatives, Useful as Anticancer Agent"(6,673,814)
    ·Pending: PCT/US2008/064723, Gambogic Acid and its Derivatives Useful for Treatment of Neurodegenerative Diseases
    ·Pending: PCT/US2008/075859, Gambogic amine, a Water Soluble Drug for Neurodegenerative Disease
    ·Pending: 61/083,658, 61/089,260, and 61/118,910, 7,8-dihydroxyflavone and its derivatives useful for neurodegenerative diseases
    ·Pending: 61/084,117 and 61/118,907, gedunin and its derivatives useful for neurodegenerative diseases
    ·Pending: 61/161,911, Catecholamine derivatives as TrkB Agonists, Useful for Treatment of Neurological Diseases and Obesity

    Active Grants:

    Federally Funded -
    ·PI, NIH RO1
    Nuclear GTPase PIKE Regulation and Functions.
    RO1 NS045627; $1,613,800, January 2004-December, 2014
    ·PI, NIH R01
    Phosphorylation of Acinus Regulates its Biological Functions
    RO1 NS060680; $1,937,500; January 1st, 2009-December 31st, 2013
    ·PI, NIH R01
    Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    RO1 DC010204; $1,646,875; October 1st, 2009-September 30th, 2014
    Previous Funding: -
    ·Co-PI, NIH NIA
    Emory Alzheimer's Disease Research Center
    Catecholamine-derived TrkB agonists for Alzheimer's disease treatment
    P50 AG025688; $192,730; May 1st, 2010-April 30, 2015
    ·Co-PI, NIH NCI
    Emory Chemical Biology Discovery Center
    Interrogation of Key Genomic Alterations in Glioblastoma Multiforme (GBM) for
    Identification of Molecular Pathways Critical to GBM Tumorigenesis and Progression
    29XS132 ST 04; June, 2010 - December, 2011
    ·PI, NIH RO1
    The Role of Merlin Phosphorylation on Tumor Suppressive Activity.
    RO1 CA117872; $1,702,700; March, 2006-February, 2011
    ·PI, NIH RO1
    Molecular Regulation and Biological Functions of PIKE-A.
    RO1 CA CA127119
    $1,937,500; July 1st, 2008-June 30th, 2013
    ·PI, Department of Defense
    Neurofibromatosis Researcher-Initiated Award
    $1,110,363; February, 2006-January, 2010
    ·PI, Department of Defense
    Neurofibromatosis New Investigator Award, $554,200
    "Neurofibromatosis 2 Tumor Suppressor, Merlin, Inhibits PIKE/PI 3-Kinase Signaling"
    2003 - 2006
    ·PI, The Sontag Foundation
    Distinguished Young Scientist Award, $500,000
    PIKE-A, a novel GTPase that mediates human brain cancer invasion through regulating Akt
    2003 - 2006
    ·PI, American Cancer Society for Research Scholar, TBE-105131,
    Dissection of the Nuclear GTPase PIKE Signaling, $797,800,
    January 2004 - December 2007

    Current Post-doctoral Fellows:

    Lab Manager

    Previous Postdoc Fellows: