Pancreatic and Hepatobiliary Pathology

Second opinions on pancreatic and hepatobiliary pathology cases are performed by -

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N. Volkan Adsay, MD

Vice Chair and Director of Anatomic Pathology
Pathology & Laboratory Medicine

Other Appointments/Positions

Director, Anatomic Pathology, Pathology & Laboratory Medicine, Emory University SOM

Vice-Chair of Anatomic Pathology, Emory University

Pathology Division(s):
Anatomic Pathology

Email Address:
Volkan.Adsay@emoryhealthcare.org

Education:

MD   Hacettepe University School of Medicine, - 1988

Resident   Otolaryngology and Head and Neck Surgery Hacettepe Univ. Faculty of Medicine, Ankara, Turkey, - 1990

Resident and Chief Resident   Anatomic and Clinical Pathology, Lenox Hill Hospital, New York University, New York, - 1994

Fellow   Oncologic Pathology Memorial Sloan-Kettering Cancer Center, New York, - 1995

Chief Fellow   Department of Pathology Memorial Sloan-Kettering Cancer Center, New York, - 1996

Research Interests:

- Oncologic Pathology, Pancreatic and Hepatobiliary Pathology, Carcinogenesis

Clinical Focus:

Director of Anatomic Pathology

Honors / Awards:

Named to Best Doctors in America

Excellence in Pathology Education Award by Medical Students, Wayne State University

College Teaching Award, Wayne State University

Listed in Who is Who in America (in Medicine; in Science and Engineering)

Member of the NCI Progress Review Group on Pancreas Cancer

Chief Resident, Department of Pathology at Lenox Hill Hospital

Chief Fellow, Department of Pathology at Memorial Sloan-Kettering Cancer Center

Awarded J-1 Visa Waiver, requested by the National Institute of Health (NIH) based on the Outstanding Researcher Status Faculty Award by The Pathology Residents and Residency Committee, Wayne State University

Ranked at 99th Percentile among 10,000 Medical School Graduates in National Medical Specialty Placement Examination, Turkey

Specialty Boards:

1996 Diplomate Pathology (AP/CP)

Selected Publications:

Published and Accepted Research Articles -

Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng CX, Hruban RH, Adsay NV, Tuveson DA, Hingorani SR. Kras(G12D) and Smad4/Dpc4 Haploinsufficiency Cooperate to Induce Mucinous Cystic Neoplasms and Invasive Adenocarcinoma of the Pancreas. Cancer Cell 11(3):229-43, 2007.

Basturk O, Zamboni G, Klimstra DS, Capelli P, Andea A, Kamel NS, Adsay NV. Intraductal and Papillary Variants of Acinar Cell Carcinomas: A New Addition to the Challenging Differential Diagnosis of Intraductal Neoplasms. American Journal of Surgical Pathology 31(3):363-370, 2007.

Saidi RF, Chang J, Verb S, Brooks S, Nalbantoglu I, Adsay V, Jacobs MJ. The effect of methylprednisolone on warm ischemia-reperfusion injury in the liver. American Journal of Surgery 193(3):345-7, discussion 347-8, 2007.

Othman M, Basturk O, Groisman G, Krasinskas A, Adsay NV. Squamoid cyst of pancreatic ducts: A distinct type of cystic lesion in the pancreas. Am J Surg Pathol.31 (2):291-7, 2007.

Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay NV, Wicha M, Clarke MF, Simeone DM. Identification of pancreatic cancer stem cells. Cancer Res. 1;67(3):1030-7, 2007.

Liao JD, Adsay NV, Khannani F, Grignon D, Thakur A, Sarkar FH. Histological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancer. Histol Histopathol. 22(6):661-76, 2007.

Francis WP, Goldberg E, Adsay NV, Steffes CP, Webber JD. Solid-pseudopapillary tumors of the pancreas: case report and literature review. Curr Surg. Nov-Dec; 63(6):469-72, 2006.

Adsay NV, Bandyopadhyay S, Basturk O. Duct adjacent to a thick-walled medium- sized muscular vessel in the pancreas is often indicative of invasive adenocarcinoma. American Journal of Surgical Pathology 30(9): 1203-5, 2006.

Adsay NV. Role of MUC Genes and Mucins in Pancreatic Neoplasia. American Journal of Gastroenterology 101(10): 2330-2, 2006.

Cao D, Antonescu C, Wong G, Winter J, Maitra A, Adsay NV, Klimstra DS, Hruban RH. Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations. Modern Pathology. 19(9): 1157-63, 2006.

Singh R, Basturk O, Klimstra DS, Zamboni G, Chetty R, Hussain S, La Rosa S, Yilmaz A, Capelli P, Capella C, Cheng JD and Adsay NV. Lipid-Rich Variant of Pancreatic Endocrine Neoplasms. American Journal of Surgical Pathology 30(2): 194-200, 2006.

Zhang Y, Banerjee S, Wang Z, Xu H, Zhang L, Mohammed R, Aboukameel A, Adsay NV, Che M, Abbruzzese JL, Majumdar AP, Sarkar FH. Antitumor Activity Of Epidermal Growth Factor Receptor-Related Protein Is Mediated By Inactivation Of Erbb Receptors And Nuclear Factor-KappaB In Pancreatic Cancer. Cancer Research 66(2): 1025-32, 2006.

Nassar H, Qureshi H, Adsay NV, Visscher D. Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. American Journal of Surgical Pathology 30(4): 501-7, 2006.

Hruban RH, Adsay NV, Albores-Saavedra J, Anver MR, Biankin AV, Boivin GP, Furth EE, Furukawa T, Klein A, Klimstra DS, Kl¿ppel G, Lauwers GY, Longnecker DS, L¿ttges J, Maitra M, Offerhaus GJA, P¿rez-Gallego L, Redston M and Tuveson DA. Pathology of Genetically Engineered Mouse Models of Pancreatic Exocrine Cancer: Consensus Report and Recommendations. Cancer Research 66(1): 95-106, 2006.

Radich GA, Altinok D, Adsay NV, Soulen RL. Papillary adenocarcinoma in a small bowel duplication in a pregnant woman. AJR Am J Roentgenol 186(3): 895-7, 2006.

Liao D, Wang Y, Wu J, Adsay NV, Grignon D, Khanani F, Sarkar FH. Characterization of pancreatic lesions from MT-tgfalpha, Ela-myc and MT-tgfalpha/Ela-myc single and double transgenic mice. J Carcinog Jul 5; 5(1):19, 2006.

McHugh JB, Thomas DG, Herman JM, Ray ME, Baker LH, Adsay NV, Rabah R, Lucas DR. Primary versus radiation-associated craniofacial osteosarcoma: biologic and clinicopathologic comparisons. Cancer 107(3):554-62, 2006

Adsay NV, Basturk O, Thirabanjasak D. Diagnostic features and differential diagnosis of autoimmune pancreatitis. Seminars Diagnostic Pathology 22(4): 309-17, 2005.

Chetty R, Asa SL, Adsay NV. Pancreatic Endocrine Tumors with Ductules. American Journal of Surgical Pathology 29(1): 136-7, 2005.

Korkmaz H, Du W, Yoo GH, Enamorado II, Lin HS, Adsay NV, Kewson D, Ensley JF, Shibuya TY, Jacobs JR, Kim H. Prognostic Significance of G1 Cell Cycle Inhibitors in Early Laryngeal Cancer. American Journal of Otolaryngology 26(2): 77-82, 2005.

Cao D, Maitra A, Saavedra JA, Klimstra DS, Adsay NV, Hruban RH. Expression of Novel Markers of Pancreatic Ductal Adenocarcinoma in Pancreatic Non-Ductal Neoplasms: Additional Evidence of Different Genetic Pathways. Modern Pathology 18(6): 752-61, 2005.

Adsay NV, Basturk O. [Squamous Dysplasia: Diagnosis, Classification and Clinico-Biologic Significance from Pathologists' Perspective.] (Turkish). Kulak Burun Bogaz ve Bas Boyun Cerrahisinde Guncel Yaklasim 1(3): 23-30, 2005.

Adsay NV, Basturk O, Bonnett M, Kilinc N, Andea A, Feng J, Che M, Aulicino M, Levi, E, Cheng JD. Proposal for A New And More Practical Grading Scheme for Pancreatic Ductal Adenocarcinoma. American Journal of Surgical Pathology 29(6): 724-733, 2005.

Basturk O, Khanani F, Sarkar F, Levi E, Cheng JD, Adsay NV. Deltanp63 Expression in Pancreas and Pancreatic Neoplasia. Modern Pathology 18:1193-98, 2005.

Khayyata S, Basturk O, Adsay NV. Invasive Micropapillary Carcinomas of the Ampullo-Pancreatobiliary Region and Their Association with Tumor Infiltrating Neutrophils. Modern Pathology 18(11): 1504-11, 2005.

Longnecker DS, Adsay NV, Fernandez-del Castillo C, Hruban RH, Kasugai T, Klimstra DS, Kloppel G, Luttges J, Memoli VA, Tosteson TD, Yanagisawa A, Wilentz R, Zamboni G. Histopathological Diagnosis of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary-Mucinous Neoplasms: Interobserver Agreement. Pancreas 31(4): 344-9, 2005.

El-Rayes BF, Zalupsi MM, Shields AF, Ferris AM, Vaishampayan U, Heilbrun LK, Venkatramanamoorthy R, Adsay V, Philip PA. A Phase II Study of Celecoxib, Gemcitabine, and Cisplatin in Advanced Pancreatic Cancer. Invest New Drugs, 583-90, 2005.

Tanaka M, Chari S, Adsay NV,Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S. International Guideline for Management Of Intraductal Papillary-Mucinous Neoplasms And Mucinous Cystic Neoplasms. A Consensus of the Working Group of the International Association of Pancreatology. Pancreatology 6(1-2): 17-32, 2005.

Andea A, Basturk O, Adsay NV. Pancreatic Intraepithelial Neoplasia: Current Clinicopathological and Molecular Considerations. Current Diagnostic Pathology 11:80-94, 2005.

Adsay NV, Basturk O, Cheng JD, Andea. A. Ductal Neoplasia of the Pancreas: Nosologic, Clinico-Pathologic and Biologic Aspects. Seminars in Radiation Oncology 15(4): 254-64, 2005.

Adsay NV, Andea A, Basturk O, Kilinc N, Nassar H, Cheng JD. Secondary Tumors of the Pancreas: An Analysis of A Surgical and Autopsy Database And Review of the Literature. Virchows Archives 444 (6): 527-35, 2004.

Adsay NV, Merati K, Basturk O, Iacobuzio-Donahue C, Levi E, Cheng JD, Sarkar FH, Hruban RH, Klimstra DS. Pathologically and Biologically Distinct Types of Epithelium in Intraductal Papillary Mucinous Neoplasms: Delineation Of an "Intestinal" Pathway of Carcinogenesis in the Pancreas. American Journal of Surgical Pathology 28(7): 839-48, 2004.

Van Heek NT, Maitra A, Koopmann J, Fedarko N, Jain A, Rahman A, Iacobuzio-Donahue CA, Adsay NV, Ashfaq R, Yeo CJ, Cameron JL, Offerhaus JA, Hruban RH, Berg KD, Goggins M. Gene Expression Profiling Identifies Markers of Ampullary Adenocarcinoma. Cancer Biology and Therapy 3(7): 651-6, 2004.

Adsay NV, Basturk O, Klimstra DS, Kl¿ppel G. Pancreatic Pseudotumors: Non-Neoplastic Solid Lesions of the Pancreas That Clinically Mimic Pancreas Cancer. Seminars in Diagnostic Pathology 21(4): 260-267, 2004.

Andea AA, Klimstra DS, Adsay NV. Colloid Carcinoma of the Pancreas. Journal of Clinical Pathology, 2004.

Hruban RH, Takaori K, Klimstra DS, Adsay NV, Albores-Saavedra J, Biankin AV, Biankin SA, Compton C, Fukushima N, Furukawa T, Goggins M, Kato Y, Kloppel G, Longnecker DS, Luttges J, Maitra A, Offerhaus GJ, Shimizu M, Yonezawa S. An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms. American Journal of Surgical Pathology 28(8): 977-87, 2004.

Bismar TA, Basturk O, Gerald WL, Schwarz K, Adsay NV. Desmoplastic Small Cell Tumor in the Pancreas. American Journal of Surgical Pathology 28(6): 808-12, 2004.

Adsay NV, Zamboni G. Paraduodenal Pancreatitis: A Clinico-Pathologically Distinct Entity Unifying "Cystic Dystrophy Of Heterotopic Pancreas", "Para-Duodenal Wall Cyst", And "Groove Pancreatitis". Seminars in Diagnostic Pathology 21(4): 247-54, 2004.

Levi E, Klimstra DS, Andea A, Basturk O, Adsay NV. MUC1 and MUC2 in Pancreatic Neoplasia. Journal of Clinical Pathology 57(5): 456-62, 2004.

Kloppel G, Adsay NV, Klimstra DS. Pancreatitis: An Introduction to History, Etiology and Pathogenesis. Seminars in Diagnostic Pathology 21(4): 219-20, 2004.

Klimstra DS, Adsay NV. Lymphoplasmacytic Sclerosing (Autoimmune) Pancreatitis. Seminars in Diagnostic Pathology 21(4): 237-46, 2004

Adsay NV, Bandyopadhyay S, Basturk O, Othman M, Cheng JD, Kl¿ppel G, Klimstra DS. Chronic Pancreatitis or Pancreatic Ductal Adenocarcinoma? Histopathologic Criteria for the Differential Diagnosis. Seminars in Diagnostic Pathology 21(4): 268-276, 2004.

Calhoun ES, Jones JB, Ashfaq R, Adsay NV, Baker SJ, Valentine V, Hempen PM, Hilgers W, Yeo CJ, Hruban RH, Kern SE. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer: Potential Therapeutic Targets. American Journal of Pathology 163(4): 1255-60, 2003.

Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, Cameron JL, Yeo CJ, Hruban RH. Multicomponent Analysis of the Pancreatic Adenocarcinoma Progression Model Using A Pancreatic Intraepithelial Neoplasia Tissue Microarray. Modern Pathology 16(9): 902-12, 2003.

Newman LA, Pernick NL, Adsay NV, Carolin KA, Philip PI, Sipierski S, Bouwman DL, Kosir MA, White M, Visscher DW. Histopathologic Evidence of Tumor Regression in the Axillary Lymph Nodes of Patients Treated with Preoperative Chemotherapy Correlates with Breast Cancer Outcome. Annals of Surgical Oncology 10(7): 734-9, 2003.

Lucas DR, Pass HI, Madan SK, Adsay NV, Wali A, Tabaczka P, Lonardo F. Sarcomatoid Mesothelioma and Its Histological Mimics: A Comparative Immunohistochemical Study. Histopathology 42(3): 270-9, 2003.

Pernick NL, Sarkar FH, Philip PA, Arlauskas P, Shields AF, Vaitkevicius VK, Dugan, MC, Adsay NV. Clinicopathologic Analysis Of Pancreatic Adenocarcinoma In African- American And Caucasians. Pancreas 26(1): 28-32, 2003.

Adsay, NV, Kambiz M, Nassar H, Shia J, Sarkar F, Pierson CR, Cheng JD, Visscher DW, Hruban RH, Klimstra DS. Pathogenesis Of Colloid (Pure Mucinous) Carcinoma Of Exocrine Organs: Coupling Of Gel-Forming Mucin (MUC2) Production With Altered Cell Polarity And Abnormal Cell-Stroma Interaction May Be The Key Factor In The Morphogenesis And Indolent Behavior Of Colloid Carcinoma In The Breast And Pancreas. The American Journal of Surgical Pathology 27(5): 571-8, 2003.

El-Rayes BF, Zalupski MM, Shields AF, Vaishampayan U, Heilbrun LK, Jain V, Adsay NV, Day J, Philip PA. Phase II Study of Gemcitabine, Cisplatin, And Infusional Fluorouracil in Advanced Pancreatic Cancer. Journal of Clinical Oncology 21(15): 2920-5, 2003.

Andea A, Sarkar F, Adsay NV. Clinicopathological Correlates of Pancreatic Intraepithelial Neoplasia: A Comparative Analysis Of 82 Cases with And 152 Cases without Pancreatic Ductal Adenocarcinoma. Modern Pathology 16(10): 996-1006, 2003

Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, Berg K. Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH. Highly Expressed Genes in Pancreatic Ductal Adenocarcinomas: A Comprehensive Characterization of the Transcription Profiles Obtained from Three Major Technologies. Cancer Research 63(24): 8614-22, 2003.

Al-Sukhun S, Zalupski MM, Ben-Josef E, Vaitkevicius VK, Philip PA, Soulen R, Weaver D, Adsay NV, Heilbrun LK, Levin K, Forman JD, Shields, AF. Chemoradiotherapy in the Treatment of Regional Pancreatic Carcinoma: A Phase II Study. American Journal of Clinical Oncology 26(6): 543-9, 2003.

Adsay NV. The "New Kid On The Block": Intraductal Papillary Mucinous Neoplasms Of The Pancreas: Current Concepts And Controversies. Surgery 133(5): 459-63, 2003.

Marciniak DJ, Moragoda I, Mohammad RM, Yu Y, Nagothu KK, Aboukameel A, Sarkar FH, Adsay NV, Rishi AK, Majumdar AP. Epidermal Growth Factor Receptor-Related Protein: A Potential Therapeutic Age for Colorectal Cancer. Gastroenterology 124(5): 1337-47, 2003.

Majumdar AP, Du J, Hatfield JS, Levi E, Adsay NV, Schmelz EM, Nagothu KK, Jaszewski R, Kucuk O, Sarkar FH. Expression Of EGF-Receptor Related Protein (ERRP) Decreases In Gastric Mucosa During Aging And Carcinogenesis. Digestive Diseases and Sciences 48(5): 856-64, 2003.

Korkmaz H, Yoo GH, Du W, Hocwald E, Otero-Garcia JE, Adsay NV, Shibuya T, Jacobs JR. Predictors of Nodal Metastasis in Salivary Gland Cancer. Journal of Surgical Oncology 80:186-89, 2002.

Feng J, Adsay NV, Kruger M, Ellis KL, Nagothu K, Majumdar AP, Sarkar FH. Expression of ERRP in Normal and Neoplastic Pancreata and Its Relationship to Clinicopathologic Parameters In Pancreatic Adenocarcinoma. Pancreas 25(4): 342-349, 2002.

Pernick NL, Sarkar FH, Tabaczka P, Kotcher G, Frank J, Adsay NV. Fas and Fas Ligand Expression in Pancreatic Adenocarcinoma. Pancreas 25(3): E36-41, 2002.

Adsay NV, Merati K, Andea A, Sarkar F, Hruban RH, Wilentz RE, Goggins M, Iocobuzio-Donahue C, Longnecker DS, Klimstra DS. The Dichotomy In The Preinvasive Neoplasia To Invasive Carcinoma Sequence In The Pancreas: Differential Expression Of MUC1 And MUC2 Supports The Existence Of Two Separate Pathways Of Carcinogenesis. Modern Pathology 15(10): 1087-95, 2002

Seidel G, Zahurak M, Iacobuzio-Donahue C, Sohn TA, Adsay NV, Yeo CJ, Lillemoe, KD, Cameron L, Hruban RH, Wilentz RE. Almost All Infiltrating Colloid Carcinomas Of Pancreas And Periampullary Region Arise From In Situ Papillary Neoplasms: A Study Of 39 Cases. The American Journal of Surgical Pathology 26(1): 56-63, 2002.

Adsay NV, Hasteh F, Cheng JD, Bejarano PA, Lauwers GY, Batts KP, Kloppel G, Klimstra DS. Lymphoepithelial Cysts of the Pancreas: A Report Of 12 Cases and Review of the Literature. Modern Pathology 15(5): 492-501, 2002.

Glazyrin AL, Chinni S, Alhasan S, Adsay NV, Vaitkevicius VK, Sarkar FH. Molecular Mechanism (S) Of Actinomycin-D Induced Sensitization Of Pancreatic Cancer Cells To CD95 Mediated Apoptosis. International Journal of Oncology 20(1): 201-5, 2002.

Adsay NV, Conlon KC, Zee SY, Brennan MF, Klimstra DS. Intraductal Papillary- Mucinous Neoplasms of the Pancreas: An Analysis Of In Situ and Invasive Carcinomas In 28 Patients. Cancer 94(1): 62-77, 2002.

Adsay NV. Intraductal Papillary Mucinous Neoplasms of the Pancreas. Pathology and Molecular Genetics. Journal of Gastrointestinal Surgery 6(5): 656-659, 2002.

Korkmaz H, Adsay NV, Jacobs JR, Lucas DR. Lipomatous Pleomorphic Adenoma of Parotid Gland. Histopathology 40(5): 487-8, 2002.