Profile of a Pathology Faculty Member

Pathology Faculty Photo

Max Dale Cooper, MD

Immunology

Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

  • Eminent Scholar, Georgia Research Alliance
  • Professor, Emory Center for AIDS Research, Emory University
  • Professor, Emory Vaccine Center, Emory University

Pathology Division(s):
Experimental Pathology
Email Address:   max.cooper@emory.edu

Education:

M. D.   Tulane University Medical School, 1955 - 1957

Research Interests:

My laboratory pursues ontogenetic and phylogenetic studies of the adaptive immune system in parallel with the analysis of immunological diseases in humans. Current projects include the role of immunoglobulin and non-immunoglobulin genes in B cell development, and the evolution of adaptive immune systems in vertebrates.

Selected/Most Recent Publications:

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Published and Accepted Research Articles -

  • Herrin, B.R., Alder, M.N., Roux, R.H., Sina, C., Ehrhardt, G.R.A., Boydston, J.A., Turnbough, Jr., C.L., and Cooper, M.D.: Structure and Specificity of Lamprey Monoclonal Antibodies. Proc. Natl. Acad. Sci. USA 105(6):2040-2045, 2008.
  • Alder, M.N., Herrin, B.R., Sadlonova, A., Stockard, C.R., Grizzle, W.E., Gartland, L.A., Gartland, G.L., Boydston, J.A., Turnbough, Jr., C.L., and Cooper, M.D.: Antibody responses of variable lymphocyte receptors in the lamprey. Nat. Immunol. 9:319-327, 2008.
  • Haga, C.L., Ehrhardt, G.R.A., Boohaker, R.J., Davis, R.S., and Cooper, M.D.: Fc Receptor-like 5 inhibits B cell activation by recruiting SHP-1 tyrosine phosphatase. Proc. Natl. Acad. Sci. USA. 104:9770-9775, 2007.
  • Hirano, M., Davis, R.S., Fine, W.D., Nakamura, S., Shimizu, K., Yagi, H., Kato, K., Stephan, R.P., and Cooper, M.D.: IgEb immune complexes activate macrophages via Fc¿RIV binding. Nat. Immunol. 8:762-771, 2007.
  • Goitsuka, R., Chen, C.H., Benyon, L., Asano, Y., Kitamuira, D., and Cooper, M.D.: Chicken cathelicidin-1, an antimicrobial guardian at the mucosal M cell gateway. Proc. Natl. Acad. Sci. USA. 104:15063-15068, 2007.
  • Litman, G.W., and Cooper, M.D.: Why study the evolution of immunity? Nat. Immunol. 8:547-548, 2007.
  • Munfus, D.L., Haga, C.L., Burrows, P.D., and Cooper, M.D.: A conserved gene family encodes transmembrane proteins with fibronectin, immunoglobulin and leucine rich repeat domains (FIGLER). BMC Genomics. 5:36, 2007.
  • Pancer, Z., and Cooper, M.D.: The evolution of adaptive immunity. Ann. Rev. Immunol. 24:497-518, 2006.
  • Fujiwara, N., Kitamura, D., Cooper, M. D., Hozumi, N., Chen, C. H., and Goitsuka, R.: A novel avian homologue of CD72, chB1r, down-modulates BCR-mediated activation signals. Int. Immunol. 18:775-783, 2006.
  • Cooper, M. D., and Alder, M. N.: The Evolution of Adaptive Immune Systems. Cell 124:815-822, 2006.
  • Zhang, Z., Espinoza, C. R., Yu, Z., Stephan, R., He, T., Williams, G. S., Burrows, P. D., Hagman, J., and Cooper, M. D.: Transcription factor Pax5/BSAP transactivates the RAG-mediated VH->DJH rearrangement of immunoglobulin genes. Nat. Immunol. 7:616-624, 2006.
  • Maltai, L., Lovering, R., Taranin, A. V., Colonna, M., Ravetch, J. V., Dalla-Favera, R., Burrows, P. D., Cooper, M. D., and Davis, R. S.: New proposed nomenclature for the Fc receptor-like (FCRL) family. Nat. Immunol. (Correspondence). 7:431-432, 2006.
  • Pancer, Z., Kasahara, M., Saha, N. R., Kasamatusu, J., Amemiya, C. T., and Cooper, M. D.: Variable lymphocyte receptors in hagfish. Proc. Natl. Acad. Sci. USA 102:9224-9229, 2005.
  • Kang, S-M., Narducci, M. G., Picchio, M. D., Mongiovi, A. M., Lazzeri, C., Caprini, E., Remotti, D., Bichi, R., Rothstein, J., Croce, C. M., Cooper, M. D., and Russo, G.: Impaired T and B cell development in Tcl1 deficient mice. Blood 105:1288-1294, 2005.
  • Leu, C-M., Davis, R. S., Gartland, L. A., Fine, W. D., and Cooper, M. D.: FcRH1: an activation co-receptor on human B cells. Blood 105:1121-1126, 2005.

Book Chapters -

  • Ehrhardt, G. R. A., Leu, C-M., Zhang, S., Aksu, G., Jackson, T., Haga, C., Hsu, J. T., Schreeder, D., Davis, R. S., and Cooper, M. D.: Fc receptor-like proteins (FCRL): immunomodulators of B cell function. In: Mechanisms of Lymphocyte Activation and Immune Regulation XI: B Cell Biology, S. Gupta, M. Cooper, K. Rajewsky, F. W. Alt, and F. Melchers, eds. Springer Publishers, NY., 2007. pp. 155-162.
  • Schroeder, H. W. and Cooper, M. D.: Immunodeficiency diseases. In: Williams Hematology, 7th Edition, Chapter 82. M. A. Lichtman, E. Beutler, T. J. Kipps, U. Seligsohn, K. Kaushansky, and J. T. Prchal, eds. McGraw-Hill Publishers, 2006. pp. 1099-1107.
  • Cooper, M. D. and Schroeder, H. W., Jr.: Primary immune deficiency diseases. In: Harrison's Principles of Internal Medicine, 16th Edition. D. L. Kasper, E. Braunwald, A. S. Fauci, S. L. Hauser, D. L. Longo, J. L. Jameson, eds. The McGraw-Hill Companies, Inc. , 2004. pp. 1939-1947.
  • Wang, J. O. and Cooper, M. D.: Aminopeptidase A. In: Handbook of Proteolytic Enzymes. 2nd Edition. A. J. Barrett, N. Rawlings, and F. Woessner, eds. Academic Press, 2004. pp. 299-303.
  • Burrows, P. D., LeBien, Tucker, Zhang, Z., Davis, R. S., and Cooper, M. D.: The development of human B lymphocytes. In: Molecular Biology of B Cells, Chapter 9. T. Honjo, F. W. Alt, and M. S. Neuberger, eds. Elsevier, Academic Press, London, 2004. pp. 141-154.
  • Dennis, G., Jr., Kubagawa, H. and Cooper, M. D.: Paired immunoglobulin-like receptors. In: Wiley Encyclopedia of Molecular Medicine, Vol. 5. T. E. Creighton, ed. John Wiley & Sons, Inc., New York, 2002. pp. 2375-2378.
  • Dennis, G., Jr., Chen, C-C., Kubagawa, H., and Cooper, M. D.: Phylogeny of paired Ig-like receptors. In: Activating and Inhibitory Immunoglobulin-like Receptors. M. D. Cooper, T. Takai and J. V. Ravetch, eds. Springer-Verlag, Tokyo, Japan, 2001. pp. 7-15.
  • Cooper, M. D. and Schroeder, H. W., Jr.: Primary immune deficiency diseases. In: Harrison's Principles of Internal Medicine, 15th Edition. E. Braunwald, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, J. L., Jameson, eds. McGraw Hill Publishing, 2001. pp. 1843-1851.
  • Wang, J., Chen, Y-F., Oparil, S., and Cooper, M. D.: Aminopeptidase A (APA/BP-1): an immunological overview. In: Cell-Surface Aminopeptidases: Basic and Clinical Aspects. S. Mizutani et al., eds. Elsevier Science B.V., Nagoya, Japan, 2001. pp. 75-84.
  • Wang, J. and Cooper, M. D.: Glutamyl aminopeptidase. In: Handbook of Proteolytic Enzymes. F. Woessner, N. Rawlings, and Barrett, A. J., eds. Academic Press, 1998. pp. 1002-1005.
  • Billips, L. G., Burrows, P. D. and Cooper, M. D.: The early B lymphocyte differentiation pathway in humans. In: The Handbook of Experimental Immunology, Vol. III, section 14, 5th Edition. D. M. Weir, L. A. Herzenberg, C. Blackwell, and Leonore A. Herzenberg, eds., 1997. pp. 85.1-85.7.
  • Cooper, M. D. and Lawton, A. R., III: Primary immune deficiency diseases. In: Harrison's Principles of Internal Medicine, Chapter 307, 14th Edition. A. S. Fauci, E. Braunwald, K. J. Isselbacher, J. D. Wilson, J. B. Martin, D. L. Kasper, S. L. Hauser, and D. L. Longo, eds. McGraw-Hill, Inc., New York, 1997. pp. 1783-1791.
  • Wang, J. and Cooper, M. D.: Structure and function of aminopeptidase A. In: Cell Surface-Peptidases in Health and Disease, Chapter 12. A. J. Kenny and C. M. Boustead, eds. BIOS Scientific Publishers, Oxford, 1997. pp. 193-202.
  • Atkinson, T. P. and Cooper, M. D.: MMBID-7/E CD-ROM, Antibody deficiency diseases. In: The Metabolic and Molecular Bases of Inherited Disease, CD-ROM Seventh Edition. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, eds. McGraw-Hill Publishing Co., 1997.
  • Cooper, M. D. and Burrows, P. D.: Overview: Acquired and genetic immunodeficiencies: Informative experiments of nature. In: The Handbook of Experimental Immunology, Vol. IV, section 27, 5th Edition. D. M.Weir, L. A. Herzenberg, C. Blackwell, and Leonore A. Herzenberg, eds., 1997. pp. 176.1-176.6.
  • Cooper, M. D. and Haynes, B. F.: Diseases of the thymus. In: Cecil Textbook of Medicine, 21st Edition. J.C. Bennett and F. Plum, eds. W. B. Saunders Co., Philadelphia, 1996. pp. 1437-1439.

Other Publications -

  • Cooper, M. D. and Alder, M. N.: The evolution of adaptive immune systems. Cell (Review) 124:815-822, 2006.
  • Pancer, Z., and Cooper, M. D.: The evolution of adaptive immunity. Ann. Rev. Immunol. 24:497-518, 2006
  • Zhang, Z., Burrows, P. D., and Cooper, M. D.: The molecular basis and biological significance of VH replacement. Immunol. Rev. 197:231-242, 2004.
  • Zhang, Z., Wang, Y-H., Zemlin, M., Findley, H. W., Bridges, S. L., Burrows, P. D., and Cooper, M. D.: Molecular mechanism of serial VH gene replacement. Ann. N.Y. Acad. Sci. 987:270-272, 2003.
  • Davis, R. S., Dennis, G., Jr., Kubagawa, H., and Cooper, M. D.: Homologs FcRH1-5 extend the Fc receptor family. Curr. Top. Microbiol. Immunol. 266:85-112, 2002.
  • Davis, R. S., Dennis, G., Jr., Odom, M. R., Gibson, A.W., Kimberly, R.P., Burrows, P. D., and Cooper, M. D.: Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family. Immunol. Rev. 190:123-136, 2002.
  • Chen, C-C., Kang, D-W., Cooper, M. D., and Kubagawa, H.: Mast cell regulation via paired immunoglobulin-like receptor PIR-B. Immunol. Res. 26/1-3:191-198, 2002.
  • Burrows, P. D., Stephan, R. P., Wang, Y-H., Lassoued, K., Zhang, Z., and Cooper, M. D.: The transient expression of pre-B cell receptors governs B cell development. Semin. Immunol. 14:343-349, 2002.
  • Cooper, M. D.: Exploring lymphocyte differentiation pathways. Immunol. Rev. 185:175-185, 2002.
  • Cooper, M., Dennis, G., Chen, C-C., Hurez, V., Tun, T., Alley, T., Ho, L-H., Uehara, T., Burrows, P., and Kubagawa, H.: Paired immunoglobulin-like receptors, PIR-A and PIR-B, and their phylogenetic relatives. In: 10th International Congress of Immunology, New Delhi, India, 1-6 November 1998. G. P. Talwar, I. Nath, N. K. Ganguly, and K. V. S. Rao, eds. S.p.A.-Bologna (Italy), 1998. pp. 3-9.