Profile of a Pathology Faculty Member

Pathology Faculty Photo

Andrew Scott Neish, MD

Epithelial Pathobiology
Immunology
Microbial Pathogenesis

Professor
Pathology & Laboratory Medicine

Pathology Division(s):
Anatomic Pathology
Experimental Pathology
Email Address:   aneish@emory.edu

Education:

B.A.   Wake Forest University, Winston-Salem, NC, - 1983
M.D.   University of North Carolina School of Medicine, Chapel Hill, NC, - 1988

Research Interests:

- Host-microbe interactions Host-microbe interactions: Our laboratory studies innate immunity and epithelial biology relevant to normal intestinal physiology as well as infectious (Gram negative enterocolitis), idiopathic (idiopathic inflammatory bowel disease) and developmental (necrotizing enterocolitis) inflammatory disorders of the gut. Specifically, our research program investigates the interactions of enteric pathogens and members of the normal gut microbiota and their products with epithelial cells in an effort to understand the molecular mechanisms of pathological and commensal eukaryotic-prokaryotic relationships. Eukaryotic cells recognize bacteria via surface receptors (pattern recognition receptors) that bind conserved microbial structural motifs. This includes the formyl peptide receptors, which can mediate both inflammatory and non inflammatory signaling, and potentially play key roles in normal intestinal homeostasis and response to infection. These receptors induce the formation of reactive oxygen species, which can play a wide role in host homeostatic signaling and maintenance of normal physiological functions. We are actively exploring how beneficial commensal bacteria modulate these processes. Additionally, pathogenic bacteria are thought to mediate interactions with eukaryotic cells by preformed effector proteins that are translocated into the host epithelia and usurp normal cellular functions. We are also interested in exploiting these proteins as potential therapeutics. The laboratory employs a variety of microbiologic, genetic, biochemical and cell biological techniques to approach theses questions, including use of mammalian cell culture, murine and Drosophila models and large-scale informatics approaches.
Dr. Neish's research focuses on the interactions of bacteria with human epithelial cells in an effort to understand the molecular mechanisms of immune and inflammatory reactions that may mediate pathogenic and commensal relationships.

Honors / Awards:

  • Fellow of the American Gastroenterological Association, 2011
  • American Association of University Pathologists, 2009
  • Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease, 2004-2009
  • Dean's Clinical Investigator Award, Emory University, 2001-2006
  • Albert E. Levy Science Research Award, Emory University,, 2001
  • Bugher Foundation Fellow, Program in Molecular Biology of the Cardiovascular System, 1993-1994
  • Merit Award for Academic Achievement, University of North Carolina School of Medicine, Chapel Hill, NC, 1984-1986
  • Cum Laude, Wake Forest University, Winston-Salem, NC, 1983
  • Beta Beta Beta, Wake Forest University, Winston-Salem, NC, 1982

Specialty Boards:

  •  Anatomic Pathology

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Leoni G, Alam M, Neumann P-A, Lambeth JD, Cheng G, McCoy J, Hilgarth RS, Kundu K, Murthy N, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Nusrat A1, Neish AS1 Co-senior authors. Annexin A1- FPR1-Nox1 dependent redox signaling promotes epithelial wound repair. J Clin Invest, 2013; 123(1):443-54
  • Wu H, Jones RM, Neish AS. The Salmonella effector AvrA mediates bacterial intracellular survival during infection in vivo. Cell Micro, 2012; 14:28-39.
  • Jones RM, Sloane V, Wu H, Luo L, Kumar A, Vijay-Kumar M, Gewirtz AT, Neish AS Flagellin administration protects gut mucosa tissue from irradiation induced apoptosis via MKP-7 activity. Gut; 2011 60:648-57
  • Wentworth CC, Alam A, Jones RM, Nusrat A, Neish AS. Enteric commensal bacteria induced ERK via FPR dependant redox modulation of DUSP3. J. Biol. Chem, 2011; 286:38448-38455.
  • Swanson P , Kumar A, Samarin S, Vijay-Kumar M, Kundu K, Murthy N, Hansen J, Nusrat A, Neish AS. Enteric commensal bacteria potentiates epithelial restitution via ROS-mediated inactivation of FAK phosphatases. Proc. Natl. Acad. Sci. 2011;108:8803-8
  • Wentworth CC, Jones RM, Kwon Y-M, Nusrat A, Neish AS, Commensal-Epithelial Signaling Mediated via Formyl Peptide Receptors. A J. Path, 2010; 177:2782-90.
  • Lin PW, Myers LS, Ray L, Song S-C, Nasr TR, Berardinelli AJ, Kundu K, Murthy N, Jason JM, Neish AS. Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Rad Biol& Med, 2009; 47:1205-11.
  • Kumar A, Wu H, Collier-Hyams LS, Kwon YM, Hansen JM, Neish AS. The bacterial fermentation product butyrate influences epithelial signaling via ROS mediated changes in Cullin-1 neddylation. J. Immunol. 2009;182:538-46.
  • Fournier B, Gewirtz AT, Williams IR, Neish AS, TLR5-dependent regulation of inflammation in systemic Salmonella enterica serovar Typhimurium infection. Infect Immune, 2009, 77:4121-29.
  • Jones R, Wu H, Wentworth C, Luo L, Collier-Hyams L, Neish AS. Salmonella AvrA coordinates suppression of host immune and apoptotic defenses via JNK pathway blockade. Cell Host Microbe, 2008; 3:233-44.
  • Lin PW, Nasr TR, Berardinelli AJ, Kumar A, Neish AS. The probiotic Lactobacillus GG may augment host defense by regulating apoptosis and promoting cytoprotective responses in the developing murine gut. Ped Research, 2008;64:511-6.
  • Kumar A, Wu H, Collier-Hyams LS, Hansen JM, Li T, Yamoah K, Pan Z-Q, Jones DP, Neish AS. Commensal bacteria repress cullin dependant-signaling via generation of reactive oxygen species. EMBO J. 2007;26:4457-66.
  • Yu Y, Nagai S, Wu H, Neish AS, Koyasu S, Gewirtz AT.TLR5-mediated PI3K activation negatively regulates flagellin-induced pro-inflammatory gene expression. J. Immunol. 2006; 176:6194-201.
  • Ghartey-Tagoe EB, Babbin BA, Nusrat A, Neish AS, Prausnitz MR. Plasmid DNA and siRNA transfection of intestinal epithelial monolayers by electroporation. Int. J. Pharmaceutics. 2006; 315:122-133.
  • Zeng H, Wu H, Jones R, Yu Y, Lin P, Gewirtz AT, Neish AS. Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am. J. Physiol. 2006; 290: G96-G108.

Book Chapters -

  • Bienenstock J, Gibson G, Klaenhammer T, Walker WA, Neish AS. New insights into probiotic mechanisms: A harvest from functional and metagenomic studies. Gut Microbes 2013;4:94-100
  • Jones RM, Mercante JW, and Neish AS. Reactive oxygen production induced by the gut microbiota: Pharmacotherapeutic implications. Curr. Med. Chem. 2012;19:1519-29.
  • Neish AS and Naumann M, Microbial induced immunomodulation by targeting the NF-kB system, Trends Microbiol. 2011;19:596-605.
  • Eckmann L, and Neish AS, NF-kB and mucosal homeostasis. In: Karin M ed. NF-kB. In Health and Disease, 2010, Advances in Microbiology and Immunology.
  • Neish AS, Microbes in gastrointestinal health and disease, Gastroenterology, 2009;136:65-80.
  • Lin, P., and Neish, AS, Innate immunity and epithelial biology: Special considerations of the neonatal gut. In: Neu J. ed. Neonatology: Questions and Controversies: Gastroenterology and Nutrition, 2008, Saunders/Elsevier, 51-72.
  • Neish AS. Flagellin mediated inflammation and anti-apoptosis, Themes review. Am. J. Physiol. In press
  • Neish, AS. Cell Signaling pathways as targets for bacterial evasion and immunity. In: McFall-Ngai M, Henderson B, and Ruby E. eds. The influence of bacterial communities on host biology, 2005, Cambridge University Press, 375-398.
  • Collier-Hyams LS and Neish AS. Immune Relationship between Commensal Flora and the Mammalian Host. Cell Mol Life Sci. 2005; 62: 1339-1348.
  • Neish, AS. Cell Signaling pathways as targets for bacterial evasion and immunity. In: McFall-Ngai M, Henderson B, and Ruby E. eds. The influence of bacterial communities on host biology, 2005, Cambridge University Press, 375-398.
  • Neish, AS. Bacterial inhibition of eukaryotic pro-inflammatory pathways. Immunologic Res. 2004; 29: 175-185.
  • Neish, AS. Molecular aspects of intestinal epithelial cell-bacterial interactions that determine the development of intestinal inflammation. Inflamm. Bowel. Dis. 2004; 10:159-168.
  • Neish, AS. Microbial interference with host inflammatory responses. In: Hecht G, ed. Microbial Pathogens and the Intestinal Epithelial Cell. 2003 ASM press, Washington DC.175-190.
  • Neish AS. The gut microflora and intestinal epithelial cells: A continuing dialog. Microbes and Infection, 2002; 4: 309-317.