Profile of a Pathology Faculty Member

Pathology Faculty Photo

John D Roback, MD, PhD

Transfusion Medicine

Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

  • Medical Director, Emory University Hospital, Blood Bank
  • Director, Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine
  • Medical Director, Emory Medical Laboratories
  • Vice-Chair for Clinical Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine
  • Medical Director, Emory Healthcare School of Medical Technology

Pathology Division(s):
Clinical Pathology
Experimental Pathology
Email Address:   jroback@emory.edu

Education:

Bachelor   Biophysics,The Johns Hopkins University, Baltimore, MD, 1980 - 1984
Medical Doctor   The University of Chicago, Chicago, IL, - 1994
Doctorate   Experimental Pathology, The University of Chicago, Chicago, IL, 1984 - 1994

Research Interests:

- Overview I) Metabolomic phenotyping of RBC units during prestorage transfusion to support the development and validation of metabolic biomarkers, RBC storage limits, and optimized storage approaches that can be used to improve transfusion efficacy. II) Identification of vascular effects of stored RBCs in vitro and in vivo to better understand potential adverse consequences of transfusions on recipient outcomes. III) Dissection of mechanisms underlying antibody responses to transfused RBCs in order to develop approaches to prevent and/or manage RBC allo-immunization. IV) Approaches to prevent transfusion-transmitted CMV infections. And, V) other work in transfusion including development and validation of novel blood typing instruments and development of transfusion clinical practice guidelines

Clinical Focus:

Improving the safety and efficacy of blood transfusion and hematopoietic stem cell transplantation. Current positions: Professor (tenured) in the Department of Pathology and Laboratory Medicine, Director of the Emory Center for Transfusion and Cellular Therapies, Director of the Emory University Hospital Blood Bank, and Director of the Stem Cell Processing Laboratory at Emory University Hospital, Vice-Chair of Clinical Pathology, and Medical Director of Emory Medical Laboratories. National leadership positions: Co-Chairman of the NIH/NHLBI Global Blood Safety and Availability Strategic Planning Committee, Chairman of the AABB Clinical Transfusion Medicine Committee, and Editor of the AABB Technical Manual.

Honors / Awards:

  • AABB President's Award, 2017
  • Golden Apple Teaching Award, 2002-2003
  • New Enterprise Award (1st place out of 70 entries), 2001
  • National Blood Foundation Scholar, 2000

Specialty Boards:

  •  Diplomate, American Board of Pathology in Clinical Pathology
  •  Diplomate, American Board of Pathology in Blood Banking and Transfusion Medicine

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • . Carson, J.L., Grossman, B.J., Kleinman, S., Tinmouth, A.T., Marques, M.B., Fung, M.K., Holcomb, J.B., Illoh, O., Kaplan, L.J., Katz, L.M., Rao, S.V., Roback, J.D., Shander, A., Tobian, A.A.R., Weinstein, R., and Djulbegovic, B. (2012) Red Blood Cell Transfusion: A Clinical Practice Guideline from the AABB. Ann. Int. Med. 157(1): 49-58.
  • Carson, J.L., Grossman, B.J., Kleinman, S., Tinmouth, A.T., Marques, M.B., Fung, M.K., Holcomb, J.B., Illoh, O., Kaplan, L.J., Katz, L.M., Rao, S.V., Roback, J.D., Shander, A., Tobian, A.A.R., Weinstein, R., and Djulbegovic, B. (2012) Red Blood Cell Transfusion: A Clinical Practice Guideline from the AABB. Ann. Int. Med. 157(1): 49-58.
  • Ogawa, S., Szlam, F., Chen, E., Nishimura, T., Kim, H., Roback, J.D., Levy, J., Tanaka, K (2012) A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery. Transfusion. 52(1): 14-22.
  • James, A.B., Josephson, C.D., Castillejo, M.I., Schreiber, G.B., and Roback, J.D. (2012) Epidemiological profiles of foreign-born and US-born Hispanic blood donors in a major metropolitan area in the United States. J. Blood Transfusion. 2012: ID 820514, 7 pages.
  • James, A.B., Josephson, C.D., Castillejo, M.I., Schreiber, G.B., and Roback, J.D. (2012) Epidemiological profiles of foreign-born and US-born Hispanic blood donors in a major metropolitan area in the United States. J. Blood Transfusion. 2012: ID 820514, 7 pages.
  • Murphy, E.L., Schlumpf, K., Wright, D., Cable, R., Roback, J.D., Sacher, R., and Busch, M.P. (2012) BMI and obesity in U.S. blood donors: A potential public health role for the blood centre. Public Health Nutrition. 15(6), 964-971.
  • Carson, J.L., Grossman, B.J., Kleinman, S., Tinmouth, A.T., Marques, M.B., Fung, M.K., Holcomb, J.B., Illoh, O., Kaplan, L.J., Katz, L.M., Rao, S.V., Roback, J.D., Shander, A., Tobian, A.A.R., Weinstein, R., and Djulbegovic, B. (2012) Red Blood Cell Transfusion: A Clinical Practice Guideline from the AABB. Ann. Int. Med. 157(1): 49-58.
  • Kleinman, S.H., Triulzi, D.J., Murphy, E.L., Carey, P.M., Gottschall, J.L., Roback, J.D., Carrick, J.D., Carrick, D., Mathew, S., Wright, D.J., Cable, R., Ness, P., Gajic, O., Hubmayr, R.D., Looney, M.R., and Kakaiya, R.M. (2011) The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion. 51(10): 2078-91.
  • Roback, J.D., Neuman, R.B., Quyyumi, A., and Sutliff, R. (2011) Insufficient nitric oxide bioavailability: a hypothesis to explain the adverse effects of red blood cell transfusion. Transfusion. 51: 859-866.
  • Hossain, M.S., Jaye, D.L., Pollack, B.P., Farris, A.B., Tselanyane, M.L., David, E., Roback, J.D., Gewirtz, A.T., and Waller, E.K. (2011) Flagellin, a TLR5 agonist, reduces GvHD in allogeneic HSCT recipients while enhancing anti-viral immunity. J. Immunol. 187(10): 5130-40.
  • Rios, J.A., Schlumpf, K.S., Kakaiya, R.M., Triulzi, D.J., Roback, J.D., Kleinman, S.H., Busch, M.P., Gottschall, J.L., Carey, P.M., and Nemo, G.J. (2011) Blood donations from previously transfused or pregnant donors: a multicenter study to determine the frequency of allo-exposure. Transfusion. 51(6): 1197-206.
  • Akhtari, M., Giver, C.R., Ali, Z., Flowers, C.R., Gleason, C.L., Hillyer, C.D., Kaufman, J., Khoury, H.J., Langston, A.A., Lechowicz, M.J., Lonial, S., Renfrow, H.M., Roback, J.D., Tighiouart, M., Vaughn, L., and Waller, E.K. (2010) Receiver operating curve analysis of circulating blood dendritic cell precursors and T-cells predicts response to extracorporeal photopheresis in patients with chronic graft-versus-host disease. Transfusion. 50(11): 2424-31.
  • Murad, M.H., Stubbs, J.R., Gandhi, M.J., Wang, A.T., Paul, A., Erwin, P.J., Montori, V.M., and Roback, J.D. (2010) The effect of plasma transfusion on morbidity and mortality: A systematic review and meta-analysis.
  • Roback, J.D., Caldwell, S., Carson, J., Davenport, R., Drew, M.J., Eder, A., Fung, M., Hamilton, M., Hess, J. Luban, N., Perkins, J., Sachais, B., Shander, A., Silverman, T., Snyder, E., Tormey, C., Waters, J., and Djulbegovic, B.
  • Carrick, D.M., Johnson, B., Kleinman, S.H., Vorhaben, R., Chance, S.C., Lee, J.-H., Roback, J.D., Pandey, S., Sun, Y., Busch, M.P., and Norris, P.J. (2010) Agreement among HLA antibody detection assays is higher in ever-pregnant donors and improved using a consensus cutoff. Transfusion. 51(5): 1105-16.

Book Chapters -

  • Roback, J.D. (2006) Human Herpesvirus Infections. In: Blood Banking and Transfusion Medicine (2nd Edition), Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., and Roback, J.D., eds., Churchill Livingstone, New York, NY (in press).
  • Roback, J.D. (2004) Preparation of Blood Components to Reduce CMV and Other Infectious Risks. In: Handbook of Pediatric Transfusion Medicine, pp. 93-99, Hillyer, C.D., Strauss, R., and Luban, N.L.C., eds., Academic Press, San Diego, CA.

Books Edited and Written -

  • Blood Banking and Transfusion Medicine (2nd Edition), Hillyer, C.D., Silberstein, L.E., Ness, P.M., Anderson, K.C., and Roback, J.D., eds., Churchill Livingstone, New York, NY (in press).

Other Publications -

  • Mintz, P., Roback, J.D., (2005) Editorial: The National Blood Foundation: 20 years of supporting pioneering transfusion medicine research. Transfusion. 45(8S), i.