Profile of a Pathology Faculty Member

Pathology Faculty Photo

Shiyong Li, MD, PhD

Hematopathology

Professor
Pathology & Laboratory Medicine

Other Appointments/Positions

Member, Winship Cancer Institute

Attending Hematopathologist, Emory University Hospital

Attending Molecular Genetic Pathologist, Emory University Hospital

Medical Director, Flow Cytometry Laboratory, Emory University Hospital

Director, Hematopathology, Emory University Hospital

Pathology Division(s):
Clinical Pathology

Email Address:   sli2@emory.edu

Education:

MD   AnHui Medical University, China, 1979 - 1984
PhD   University of Iowa, 1989 - 1995
Residency   University of Pennsylvania Hospital, 1995 - 1999
Fellowship   Johns Hopkins Hospital, 1999 - 2000

Research Interests:

- Hematolymphoid malignancies Using modern technology such as flow cytometry, fluorescent in situ hybridization, laser-captured microdissection and cDNA microarray, I am especially interested in (1) investigation of the underlying molecular mechanisms of leukemo/lymphomagenesis; (2) identification of new marker(s) to aid in diagnosis and in predicting the clinical outcome of malignant hematopoietic disorders; (3) development of new diagnostic tests in the field of hematopathology.

Clinical Focus:

Hematopathology - morphology, flow cytometry and molecular diagnostics Fluorescence in situ hybridization for hematolymphoid and solid organ tissue malignancies

Honors / Awards:

  • The Emory Golden Apple Teaching Award

    , 2010-2011

  • The Emory Golden Apple Teaching Award, 2003-2004
  • CUSBEA Scholar, 1989-1995

Specialty Boards:

  •  Diplomate, Anatomic and Clinical Pathology, American Board of Pathology
  •  Diplomate, Hematology, American Board of Pathology
  •  Diplomate, Molecular Genetic Pathology, American Board of Pathology

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Wang HY, Huang L, Garcia R, Li S and Galliani CA (2011) Erythroblastic Sarcoma Presenting as Bilateral Ovarian Masses in an Infant with Pure Erythroid Leukemia. Human Pathology 42:749-58.
  • Ahsanuddin A, Brynes RK and Li S (2011) Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients with angioimmunoblastic T-cell lymphoma: Report of 3 cases and review of the literature. Int J Clin Exp Pathol 4; 416-20.
  • Cotta CV, Coleman JF, Li S and His ED (2011). Progression of nodular lymphocyte predominant Hodgkin lymphoma to diffuse large B-cell lymphoma: a study of 6 cases concurrently involving the same site. Histopathology (in press)
  • Schniederjan SD, Li S, Lechowicz MJ, Terry PD and Mann KP (2010) A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10-positve diffuse large B-cell lymphoma. Am J Clin Pathol 133:718-26.
  • Li S and Lee AK (2010) Silicone implant and primary breast ALK1-negative anaplastic large cell lymphoma, fact or fiction? Int J Clin Exp Pathol 3:117-127.
  • Zapata M, Budnick SD, Bordoni R and Li S (2010). An uncommon case of de novo CD10+ CD5- mantle cell lymphoma mimics follicle center B cell lymphoma. Int J Clin Exp Pathol 3:430-6.
  • Kraus TS, Sillings CN, Saxe DF, Li S and Jaye DL (2010). The role of CD11c expression in the diagnosis of mantle cell lymphoma. Am J Clin Pathol 134:271-7.
  • Wang HY*, Li S*, Woodford RL, Cousar JB and Mills SE (2010) BCL2 chromosomal translocation is not a general feature of the interdigitating dendritic cell sarcoma. Diag Mol Pathol 19:169-71 (*co-first author)
  • Li S (2009). Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma: a distinct clinicopathological entity Int J Clin Exp Pathol 2: 508-518
  • Cao N, Li S, Wang Z, Ahmed KM, Degnan ME, Fan M, Dynlacht JR and Li J-J (2009) NF-kappB-mediated HER-2 overexpression in radiation-induced adaptive tumor resistance. Radiation Res 171, 9-21.
  • Zeng W, Styblo TM, Li S, Sepulveda JN and Schuster D (2009) Breast angiosarcoma: PDG PET findings. Clin Nucl Med 34: 443-445.
  • Salisbury CL, Budnick SD and Li S (2009) T-cell receptor gene rearrangement and CD30 immunoreactivity in traumatic ulcerative granuloma with stromal eosinophilia of the oral cavity. Am J Clin Pathol 132: 722-727.
  • Chan C-B, Hao C, Abe M, Hashimoto N, Nakao S, Liu X, Williams IR, Yepes M, Li S, Asano M, Hara-Nishimura I, Luo HR and Ye K (2009) Mice lacking asparagine endopeptidase (AEP) develop disorders resembling hemophagocytic syndrome. Proc Natl Acad Sci USA 106, 468-473.
  • Webber BA, Cushing MM and Li S (2008) Prognostic significance of flow cytometric immunophenotyping in acute myeloid leukemia. Int J Clin Exp Pathol 1:124-133.
  • Li S, Mann KP and Holden JT (2008) Composite small lymphocytic lymphoma and extramedullary myeloid tumor: a potential diagnostic pitfall. Int J Clin Exp Pathol 1, 91-97.

Book Chapters -

  • Li, S. (1999). Complementary DNA microarray: the bridge between molecular biology and pathology. In: Advances in Medical Molecular Biology, Y.-F. Shen (ed.), pp137-143, Beijing and Springer-Verlag Heidelberg.

Other Publications -

  • Li S (2011) T cell prolymphocytic leukemia. Hematopathology CheckPath Sample, Quarter 1, American Society for Clinical Pathology
  • Li S (2011) Diffuse large B-cell lymphoma - monomorphic posttransplant lymphoproliferative disorder. Hematopathology CheckPath Sample, Quarter 3, American Society for Clinical Pathology
  • Li S (2010) Burkitt lymphoma. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology
  • Woodford RL, Wang HY, Li S, Mills SE and Cousar JB. T(14;18)-negative interdigitating dendritic cell sarcomas: a morphologic and immunohistochemical review. USCAP meeting, 2010, Washington DC.
  • Li S (2010) Transformation of nodular lymphocyte-predominant Hodgkin lymphoma to diffuse large B-cell lymphoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology
  • Wertheim GBW, Roullet M, Jones D, Young KH, Li S, Wu H and Choi JK. Sensitive and specific detection of gamma T-cell receptor in paraffin-embedded T-cell lymphomas. USCAP meeting, 2010, Washington DC.
  • Li S (2009) Cutaneous mastocytoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology
  • Kossover C, Budnick S and Li S. Clonal T-cell receptor gene rearrangements in traumatic ulcerative granuloma with stromal eosinophilia. USCAP meeting, 2009, Boston.
  • Li S (2009) Peripheralization of malignant lymphoma. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology
  • Schniederjan SD, Li S, Lechowicz MJ, Terry PD and Mann KP. A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10-positve diffuse large B-cell lymphoma. USCAP meeting, 2009, Boston
  • Roullet M, Gheith S, Mauger J, Junkins-Hopkins JM, Li S and Choi JK (2008) Detecting gamma/delta T cells in panniculitis by paraffin immunohistochemistry. ACLPS meetings, Philadelphia, PA
  • Li S (2008) Primary central nervous system diffuse large B-cell lymphoma. Hematopathology CheckPath Sample, Quarter 3, American Society for Clinical Pathology
  • Roullet M, Gheith S, Cornfield D, Mauger J, Wu H, Junkins-Hopkins JM, Li S and Choi JK (2008) Detecting gamma/delta T cell lymphoma by paraffin immunohistochemistry. ACLPS meetings, Philadelphia, PA
  • Cao N, Li S, Wang Z, Degnan M, Fan M, Ahmed KM and Li J-J (2008) NF-kappB-mediated HER-2 overexpression in acquired tumor radioresistance. AACR meeting, Phoenix, Arizona
  • Kossover CL, Budnick SD and Li S (2008) Traumatic ulcerative granuloma with stromal eosinophilia: reactive ulcer or lymphoproliferative disorder? USCAP meeting, Denver, CO
  • Li S (2008) Systemic lupus lymphadenitis. Hematopathology CheckPath Sample, Quarter 2, American Society for Clinical Pathology
  • Zapata M, Choi W and Li S (2007) CD5-positive B cell lymphoma with coexpression of FMC7 and CD23: mantle cell lymphoma or small lymphocytic lymphoma? Clinical Cytometry Society meeting, Washington DC
  • Amanuel B, Deyrup AT, Hill CE, Foulks C, Blasingame A, Li S and Weiss SW (2007) Molecular testing of for synovial sarcoma. Australian Division of IAP meeting, Autralia
  • Li S (2007) Diamond-Blackfan anemia. Hematopathology CheckPath Sample, Quarter 1, American Society for Clinical Pathology
  • Li S (2007) Classical Hodgkin lymphoma. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology
  • Li S (2006) Heinz body-induced hemolysis. Hematopathology CheckPath Sample, Quarter 4, American Society for Clinical Pathology
  • Cushing MM and Li S (2004) Flow cytometric immunophenotyping and cytogenetic analysis of acute myeloid leukemia (AML) at diagnosis and relapse. USCAP meeting, Vancouver, BC, Canada
  • Cushing MM and Li S (2004) Flow cytometric immunophenotyping and cytogenetic analysis of precursor B-cell acute lymphoblastic leukemia(B-ALL): Correlation with short-term treatment outcomes. USCAP meeting, Vancouver, BC, Canada
  • Zornosa X and Budnick S and Li S (2003) Lymphoma of the head and neck: a retrospective study. Am Acad Oral Maxillofacial Pathol Meeting, Banff, Canada
  • Li S, Chen X and Jensen PE (2003) HLA-DO: a useful marker to distinguish florid follicular hyperplasia from follicular lymphoma by flow cytometry. USCAP meeting, Washington DC
  • Li S (2002) Monoclonal expansion of CD8+ T cells in a 14 year old boy with acute infectious mononucleosis. Case studies in Clinical Flow Cytometry http://www.flowcases.org/website/index.cfm.
  • Chen X, Laur O, Kambayashi T, Li S, Bray RA, Weber DA, Karlsson L and Jensen PE (2001) Regulated expression of HLA-DO during antigen dependent and independent phases of B cell development. ASHI meeting, San Francisco, CA
  • Li S, Mann KP and Holden JT (2001) Hepatosplenic alpha/beta T-cell lymphoma is clinicopathologically indistinguishable from its gamma/delta counterpart. Case studies in Clinical Flow Cytometry. http://www.flowcases.org/website/index.cfm.
  • Li, S, Eshleman JR and Borowitz MJ (2001) Lack of surface immunoglobulin light chain expression by flow cytometry can help diagnose peripheral B-cell non-Hodgkin's lymphoma. USCAP meeting, Atlanta, GA
  • Li S, Ross DT, Kadin ME, Brown PO and Wasik MA (2000) Comparative genome-scale analysis of gene expression profiles in T-cell lymphoma cell lines during malignant progression using a complementary DNA microarray. USCAP meeting, New Orleans, LA
  • Li S, Baloch ZW, Tomaszewski JE and LiVolsi VA (1999) Worrisome histologic alterations after fine needle aspiration of benign parotid lesions. IAP meeting, France