Profile of a Pathology Faculty Member

Pathology Faculty Photo

Tristram G. Parslow, MD, PhD

Microbial Pathogenesis
HIV Pathogenesis

William Patterson Timmie Professor and Chair
Pathology & Laboratory Medicine

Other Appointments/Positions

  • Chief of Pathology Section, The Emory Clinic
  • Attending Pathologist, Emory Healthcare, Emory University Hospital, and Crawford Long Hospital
  • Member, Board of Directors, The Emory Clinic
  • Member, Board of Directors, Emory Medical Care Foundation
  • National Council Member, Association of Pathology Chairs

Pathology Division(s):
Experimental Pathology
Email Address:   tparslo@emory.edu

Education:

BA (Biology)   Grinnell College, - 1977
MD Medicine; PhD Biochem   University of Iowa College of Medicine, - 1983
Residency   Anatomic Pathology, University of California, San Francisco, - 1985
Postdoctoral Research   Laboratory of Dr. Keith R. Yamamoto, Dept. of Biochemistry and Biophysics, University of California, San Francisco, - 1985

Research Interests:

- Molecular Virology of HIV and Influenza Our laboratory's research is focused mainly on the structure and assembly of the human immunodeficiency virus (HIV) and influenza A virus, with the goal of developing new approaches to antiviral therapy. We are particularly interested in understanding how each of these viruses is able to recognize and package its genomic RNA into new viral particles as they form within an infected cell. By combining three-dimensional structural analysis with targeted mutagenesis of virally encoded macromolecules, we are elucidating specific RNA-RNA and RNA-protein interactions that are critical for replication, and that may offer new targets for antiviral drugs.

My other scientific interests extend broadly over the fields of immunology, virology, and the molecular basis of human disease. Past projects have included studies of human telomerase RNA; of the apoptotic regulatory proteins Bcl2 and Bax; and of immune responses to multicellular parasites; as well as co-discovery of a novel form of human severe combined immunodeficiency (SCID) that results from an inherited defect in ZAP-70, a tyrosine kinase involved in T-cell receptor signaling. In addition, as a pathologist, I have enjoyed several opportunities to collaborate in characterizing novel transgenic or knockout mouse strains whose phenotypes shed light on important facets of mammalian development, immunity, and carcinogenesis.

Selected/Most Recent Publications:

Click here to view all publications

Published and Accepted Research Articles -

  • Liang Y, Huang T, Ly H, Parslow TG, Liang Y; 2008, Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments; J Virol 82:229-236
  • Mujeeb A, Ulyanov NB, Georgantis S, Smirnov I, Chung J, Parslow TG, James TL; 2007, Nucleocapsid protein-mediated maturation of dimer initiation complex of full-length SL1 stemloop of HIV-1: sequence effects and mechanism of RNA refolding; Nucleic Acids Res 35:2026-2034
  • Gipson CL, Xin ZT, Danzy SC, Parslow TG, Ly H; 2007, Functional characterization of yeast telomerase RNA dimerization; J Biol Chem 282:18857-18863
  • Ulyanov NB, Mujeeb A, Du Z, Tonelli M, Parslow TG, and James TL; 2006, NMR Structure of the Full-Length Linear Dimer of Stem-Loop 1 RNA in the HIV-1 Dimer Initiation Site; J Biol Chem 281: 16168-16177
  • Regan JC, Liang Y, and Parslow TG; 2006, Defective Assembly of Influenza A Virus Due to a Mutation in the Polymerase Subunit PA; J Virol 80: 252-261
  • Khan MA, Kao S, Miyagi E, Takeuchi H, Goila-Gaur R, Opi S, Gipson CL, Parslow TG, Ly H, and Strebel K; 2005, Viral RNA is Required for the Association of APOBEC3G with HIV-1 Nucleoprotein Complexes; J Virol 79: 5870-5874
  • Liang Y, Hong Y, and Parslow TG; 2005, Cis-Acting Packaging Sequences in the Influenza Virus PB1, PB2, and PA Genomic RNA Segments; J Virol 79: 10348-10355
  • Ly H, Calado RT, Allard P, Baerlocher GM, Lansdorp PM, Young NS, and Parslow TG; 2004, Functional Characterization of Telomerase RNA Variants Found in Patients with Hematological Disorders; Blood 105: 2332-2339
  • Lin J, Ly H, Hussain A, Abraham M, Pearl S, Tzfati Y, Parslow TG, and Blackburn EH; 2004, A Universal Telomerase RNA Core Structure Includes Structure Motifs Required for Binding the Telomerase Reverse Transcriptase Protein; Proc Natl Acad Sci USA 101: 14713-14718
  • Ly H, Xu L, Rivera M, Parslow TG and Blackburn E; 2003, A Role for a Novel "Trans-Pseudoknot" RNA-RNA Interaction in the Functional Dimerization of Human Telomerase; Genes and Devel 17:1078-1083
  • Ly H, Blackburn EH, and Parslow TG; 2003, Comprehensive Mutational Analysis of the Core Domain of Human Telomerase RNA; Molec Cell Biol 23: 6849-6856
  • Bancroft CT and Parslow TG; 2002, Evidence for Segment-Nonspecific Packaging of the Influenza A Genome; J Virol 76:7133-7139
  • Ly H and Parslow TG; 2002, A Bipartite Signal for Genomic RNA Dimerization in Moloney Murine Leukemia Virus; J Virol 76:3135-3144
  • Clever J, Miranda A, and Parslow TG; 2002, RNA Structure and Packaging Signals in the 5' Leader Region of the Human Immunodeficiency Virus Type-1 Genome; J Virol 76:12381-12387
  • Majeti R, Xu Z, Parslow TG, Olson JL, Daikh D, Killeen N and Weiss A; 2000, An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity; Cell 103:1059-1070

Book Chapters -

  • Parslow TG and Elder ME; 1995; Pathobiology of Immunodeficiency Disorders. In: Cellular and Molecular Pathogenesis, edited by Sirica A. New York:Raven Press
  • Parslow TG and Hope TJ; 1994; Structure and Expression of the HIV-1 Genome. In: The AIDS Knowledge Base (Second edition), edited by P.T. Cohen, et al. Little, Brown and Co.
  • Parslow TG; 1993; Post-Transcriptional Regulation of Human Retroviral Gene Expression. In: Molecular Biology of Human Retroviruses, edited by Cullen BR. Oxford:IRL/Oxford Press
  • LeBoit P and Parslow TG; 1987; Gene Rearrangements in Lymphoma: Applications to Dermatopathology; Am J Dermatopathol 9:212-218

Books Edited and Written -

  • Parslow TG, Stites DP, Terr AI, and Imboden JB (eds.); 2001; Medical Immunology (Tenth edition). Los Altos, CA:Lange Medical Publishers.
  • Stites DP, Terr AI, and Parslow TG (eds.); 1997; Lange Series - Medical Immunology (Ninth edition). Los Altos, CA:Lange Medical Publishers
  • Stites DP, Terr AI, and Parslow TG (eds.); 1994; Lange Series - Basic and Clinical Immunology (Eighth edition). Los Altos, CA:Lange Medical Publishers